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The Association of Lung Clearance Index with COPD and FEV1 Reduction in ‘Men Born in 1914’

Zaigham, Suneela LU ; Wollmer, Per LU and Engström, Gunnar LU (2017) In COPD: Journal of Chronic Obstructive Pulmonary Disease 14(3). p.324-329
Abstract

Lung Clearance Index (LCI) provides an overall measurement of ventilation inhomogeneity. This population-based study examines whether LCI predicts pulmonary obstruction and incidence of chronic obstructive pulmonary disease (COPD) events over a long-term follow-up. Multiple breath nitrogen washout and spirometry were performed in 674 men from the cohort “Men born in 1914” at age 55 years. Subjects were classified into quartiles (Q) of LCI and according to LCI above and below upper limit of normal (ULN). Incidence of COPD events (COPD hospitalisations or COPD-related deaths) were monitored over the remaining life span of the men, by linkage with national hospital registers. In addition, development of pulmonary obstruction (i.e.,... (More)

Lung Clearance Index (LCI) provides an overall measurement of ventilation inhomogeneity. This population-based study examines whether LCI predicts pulmonary obstruction and incidence of chronic obstructive pulmonary disease (COPD) events over a long-term follow-up. Multiple breath nitrogen washout and spirometry were performed in 674 men from the cohort “Men born in 1914” at age 55 years. Subjects were classified into quartiles (Q) of LCI and according to LCI above and below upper limit of normal (ULN). Incidence of COPD events (COPD hospitalisations or COPD-related deaths) were monitored over the remaining life span of the men, by linkage with national hospital registers. In addition, development of pulmonary obstruction (i.e., FEV1/vital capacity below lower limit of normal (LLN)) was studied in 387 men who were re-examined with spirometry at 68 years of age. Over 44 years of follow-up, there were 85 incident COPD events. Hazards ratios (HRs) for COPD across quartiles of LCI were: Q1 1.00 (reference), Q2 1.30 (95% confidence interval: 0.61–2.74), Q3 1.97 (0.97–3.98) and Q4 3.99 (2.06–7.71) (p value for trend <0.001). This relationship remained significant after adjustments for confounding factors, including smoking and FEV1 (HR, Q4 vs Q1: 2.34 (1.17–4.69); p value for trend: 0.006). Reduction of FEV1 between 55 and 68 years of age and incidence of pulmonary obstruction was highest in those with high LCI. High LCI is associated with future development of pulmonary obstruction and incidence of COPD hospitalisations in men from the general population.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chronic obstructive pulmonary disease, incidence, lung clearance index, spirometry
in
COPD: Journal of Chronic Obstructive Pulmonary Disease
volume
14
issue
3
pages
6 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85018163369
  • wos:000402073800009
ISSN
1541-2555
DOI
10.1080/15412555.2017.1314455
language
English
LU publication?
yes
id
95502ea7-99cc-4650-ba76-a012aa432bd4
date added to LUP
2017-05-24 16:26:55
date last changed
2017-09-19 08:38:56
@article{95502ea7-99cc-4650-ba76-a012aa432bd4,
  abstract     = {<p>Lung Clearance Index (LCI) provides an overall measurement of ventilation inhomogeneity. This population-based study examines whether LCI predicts pulmonary obstruction and incidence of chronic obstructive pulmonary disease (COPD) events over a long-term follow-up. Multiple breath nitrogen washout and spirometry were performed in 674 men from the cohort “Men born in 1914” at age 55 years. Subjects were classified into quartiles (Q) of LCI and according to LCI above and below upper limit of normal (ULN). Incidence of COPD events (COPD hospitalisations or COPD-related deaths) were monitored over the remaining life span of the men, by linkage with national hospital registers. In addition, development of pulmonary obstruction (i.e., FEV<sup>1</sup>/vital capacity below lower limit of normal (LLN)) was studied in 387 men who were re-examined with spirometry at 68 years of age. Over 44 years of follow-up, there were 85 incident COPD events. Hazards ratios (HRs) for COPD across quartiles of LCI were: Q1 1.00 (reference), Q2 1.30 (95% confidence interval: 0.61–2.74), Q3 1.97 (0.97–3.98) and Q4 3.99 (2.06–7.71) (p value for trend &lt;0.001). This relationship remained significant after adjustments for confounding factors, including smoking and FEV<sup>1</sup> (HR, Q4 vs Q1: 2.34 (1.17–4.69); p value for trend: 0.006). Reduction of FEV<sup>1</sup> between 55 and 68 years of age and incidence of pulmonary obstruction was highest in those with high LCI. High LCI is associated with future development of pulmonary obstruction and incidence of COPD hospitalisations in men from the general population.</p>},
  author       = {Zaigham, Suneela and Wollmer, Per and Engström, Gunnar},
  issn         = {1541-2555},
  keyword      = {Chronic obstructive pulmonary disease,incidence,lung clearance index,spirometry},
  language     = {eng},
  month        = {04},
  number       = {3},
  pages        = {324--329},
  publisher    = {Taylor & Francis},
  series       = {COPD: Journal of Chronic Obstructive Pulmonary Disease},
  title        = {The Association of Lung Clearance Index with COPD and FEV<sup>1</sup> Reduction in ‘Men Born in 1914’},
  url          = {http://dx.doi.org/10.1080/15412555.2017.1314455},
  volume       = {14},
  year         = {2017},
}