The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update
Hyöty, Heikki ; Lernmark, Åke LU
; Hagopian, William
; She, Jin-Xiong
; Schatz, Desmond A
; Ziegler, Anette G
; Toppari, Jorma
and Akolkar, Beena
(2018)
In Current Diabetes Reports
18(12).
- Abstract
- Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues,... (More)
- Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. Summary: TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D. © 2018, Springer Science+Business Media, LLC, part of Springer Nature. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/955484ba-88fa-4f94-a67b-ba153568fd6e
- author
- Hyöty, Heikki
; Lernmark, Åke
LU
; Hagopian, William
; She, Jin-Xiong
; Schatz, Desmond A
; Ziegler, Anette G
; Toppari, Jorma
and Akolkar, Beena
- author collaboration
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Autoimmunity, Children, Type 1 diabetes
- in
- Current Diabetes Reports
- volume
- 18
- issue
- 12
- article number
- 186
- publisher
- Current Science, Inc.
- external identifiers
-
- pmid:30353256
- scopus:85055450125
- ISSN
- 1539-0829
- DOI
- 10.1007/s11892-018-1113-2
- language
- English
- LU publication?
- yes
- additional info
- Export Date: 14 November 2018
- id
- 955484ba-88fa-4f94-a67b-ba153568fd6e
- date added to LUP
- 2018-11-14 12:17:49
- date last changed
- 2022-06-27 22:43:03
@article{955484ba-88fa-4f94-a67b-ba153568fd6e,
abstract = {{Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. Summary: TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.}},
author = {{Hyöty, Heikki and Lernmark, Åke and Hagopian, William and She, Jin-Xiong and Schatz, Desmond A and Ziegler, Anette G and Toppari, Jorma and Akolkar, Beena}},
issn = {{1539-0829}},
keywords = {{Autoimmunity; Children; Type 1 diabetes}},
language = {{eng}},
number = {{12}},
publisher = {{Current Science, Inc.}},
series = {{Current Diabetes Reports}},
title = {{The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update}},
url = {{http://dx.doi.org/10.1007/s11892-018-1113-2}},
doi = {{10.1007/s11892-018-1113-2}},
volume = {{18}},
year = {{2018}},
}