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The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update

, ; Hyöty, Heikki; Lernmark, Åke LU ; Hagopian, William; She, Jin-Xiong; Schatz, Desmond A; Ziegler, Anette G; Toppari, Jorma and Akolkar, Beena (2018) In Current Diabetes Reports 18(12).
Abstract
Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues,... (More)
Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. Summary: TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D. © 2018, Springer Science+Business Media, LLC, part of Springer Nature. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autoimmunity, Children, Type 1 diabetes
in
Current Diabetes Reports
volume
18
issue
12
publisher
Current Science inc.
external identifiers
  • scopus:85055450125
ISSN
1539-0829
DOI
10.1007/s11892-018-1113-2
language
English
LU publication?
yes
id
955484ba-88fa-4f94-a67b-ba153568fd6e
date added to LUP
2018-11-14 12:17:49
date last changed
2019-08-14 04:27:09
@article{955484ba-88fa-4f94-a67b-ba153568fd6e,
  abstract     = {Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. Summary: TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.},
  articleno    = {186},
  author       = {,  and Hyöty, Heikki and Lernmark, Åke and Hagopian, William and She, Jin-Xiong and Schatz, Desmond A and Ziegler, Anette G and Toppari, Jorma and Akolkar, Beena},
  issn         = {1539-0829},
  keyword      = {Autoimmunity,Children,Type 1 diabetes},
  language     = {eng},
  number       = {12},
  publisher    = {Current Science inc.},
  series       = {Current Diabetes Reports},
  title        = {The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update},
  url          = {http://dx.doi.org/10.1007/s11892-018-1113-2},
  volume       = {18},
  year         = {2018},
}