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Microcalorimetric investigation of cell metabolism in tumour cells from patients with non‐Hodgkin lymphoma (NHL)

Monti, M.; Brandt, L.; Ikomi‐Kumm, J. and Olsson, H. LU (1986) In Scandinavian Journal of Haematology 36(4). p.353-357
Abstract

The overall metabolism in tumour cells from 36 untreated patients with non‐Hodgkin lymphoma was evaluated by direct calorimetry. For 20 patients with lymphoma of high grade malignancy the median value of heat production rate per tumour cell was 3.9 pW and for 16 patients with low grade lymphomas the corresponding value was 2.8 pW. The difference between the two morphclogical groups is significant (p = 0.05). The median value of heat production rate per tumour cell from 13 patients who died within 2 yr after diagnosis was 4.0 pW. The corresponding value for 17 patients who have survived for more than 2 yr was 2.5 pW. The difference between the two groups is significant (p = 0.02). A high correlation was found between heat production... (More)

The overall metabolism in tumour cells from 36 untreated patients with non‐Hodgkin lymphoma was evaluated by direct calorimetry. For 20 patients with lymphoma of high grade malignancy the median value of heat production rate per tumour cell was 3.9 pW and for 16 patients with low grade lymphomas the corresponding value was 2.8 pW. The difference between the two morphclogical groups is significant (p = 0.05). The median value of heat production rate per tumour cell from 13 patients who died within 2 yr after diagnosis was 4.0 pW. The corresponding value for 17 patients who have survived for more than 2 yr was 2.5 pW. The difference between the two groups is significant (p = 0.02). A high correlation was found between heat production rates in tumour cells and survival of the patients (p = 0.006).

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
calorimetry, heat production, metabolism, NHL
in
Scandinavian Journal of Haematology
volume
36
issue
4
pages
353 - 357
publisher
Wiley-Blackwell
external identifiers
  • scopus:0022496413
ISSN
0036-553X
DOI
10.1111/j.1600-0609.1986.tb01749.x
language
English
LU publication?
yes
id
957d3eb6-bc2c-4bea-b262-b76a556e7d16
date added to LUP
2018-12-17 12:40:28
date last changed
2019-03-08 03:11:49
@article{957d3eb6-bc2c-4bea-b262-b76a556e7d16,
  abstract     = {<p>The overall metabolism in tumour cells from 36 untreated patients with non‐Hodgkin lymphoma was evaluated by direct calorimetry. For 20 patients with lymphoma of high grade malignancy the median value of heat production rate per tumour cell was 3.9 pW and for 16 patients with low grade lymphomas the corresponding value was 2.8 pW. The difference between the two morphclogical groups is significant (p = 0.05). The median value of heat production rate per tumour cell from 13 patients who died within 2 yr after diagnosis was 4.0 pW. The corresponding value for 17 patients who have survived for more than 2 yr was 2.5 pW. The difference between the two groups is significant (p = 0.02). A high correlation was found between heat production rates in tumour cells and survival of the patients (p = 0.006).</p>},
  author       = {Monti, M. and Brandt, L. and Ikomi‐Kumm, J. and Olsson, H.},
  issn         = {0036-553X},
  keyword      = {calorimetry,heat production,metabolism,NHL},
  language     = {eng},
  month        = {01},
  number       = {4},
  pages        = {353--357},
  publisher    = {Wiley-Blackwell},
  series       = {Scandinavian Journal of Haematology},
  title        = {Microcalorimetric investigation of cell metabolism in tumour cells from patients with non‐Hodgkin lymphoma (NHL)},
  url          = {http://dx.doi.org/10.1111/j.1600-0609.1986.tb01749.x},
  volume       = {36},
  year         = {1986},
}