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Phosphoproteomics to tackle brain disorders : Insight into the murine brain phosphoproteome

Siino, Valentina LU (2018)
Abstract
Brain disorders affect the normal functionality of the brain causing inability in controlling certain behaviours. In the last two decades, despite the technological advancement, many biological questions concerning brain mechanisms and neural networks remain still unclear. Thus, the integration of multiple technologies could help on clarify several aspects of neurobiology.
The aim of this thesis was to study the function of certain proteins and protein-protein interactions in murine brains by using mass spectrometry-based proteomics. Since one of the main switching mechanisms in cells is the
phosphorylation of proteins, the phosphoproteome of murine brains was specifically studied.
The results presented in this thesis let to... (More)
Brain disorders affect the normal functionality of the brain causing inability in controlling certain behaviours. In the last two decades, despite the technological advancement, many biological questions concerning brain mechanisms and neural networks remain still unclear. Thus, the integration of multiple technologies could help on clarify several aspects of neurobiology.
The aim of this thesis was to study the function of certain proteins and protein-protein interactions in murine brains by using mass spectrometry-based proteomics. Since one of the main switching mechanisms in cells is the
phosphorylation of proteins, the phosphoproteome of murine brains was specifically studied.
The results presented in this thesis let to the identification of phosphoproteins implicated in molecular pathways that could be responsible for brain impairment during certain conditions like obesity (Paper I and III), anxiety and depression (Paper III) and Parkinson´s disease (Paper IV). The findings of this thesis remarkably contribute to the proteomic and neurobiology fields and set phosphoproteomics as a powerful tool for the study of neuroscience. (Less)
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author
supervisor
opponent
  • Associate professor Greggio, Elisa, University of Padua, Italy
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Phosphoproteomics, mass spectrometry, brain disorders, neurobiology, phosphorylation
publisher
Department of Immunotechnology, Lund University
defense location
lecture hall Lundmarksalen, Sölvegatan 27, Lund University, Faculty of Engineering LTH, Lund
defense date
2018-04-27 09:00
ISBN
978-91-7753-610-9
978-91-7753-611-6
language
English
LU publication?
yes
id
95ba1af4-333b-4d56-bcd3-8cf89a68bf11
date added to LUP
2018-04-02 17:34:38
date last changed
2018-11-21 21:39:02
@phdthesis{95ba1af4-333b-4d56-bcd3-8cf89a68bf11,
  abstract     = {Brain disorders affect the normal functionality of the brain causing inability in controlling certain behaviours. In the last two decades, despite the technological advancement, many biological questions concerning brain mechanisms and neural networks remain still unclear. Thus, the integration of multiple technologies could help on clarify several aspects of neurobiology.<br/>The aim of this thesis was to study the function of certain proteins and protein-protein interactions in murine brains by using mass spectrometry-based proteomics. Since one of the main switching mechanisms in cells is the<br/>phosphorylation of proteins, the phosphoproteome of murine brains was specifically studied.<br/>The results presented in this thesis let to the identification of phosphoproteins implicated in molecular pathways that could be responsible for brain impairment during certain conditions like obesity (Paper I and III), anxiety and depression (Paper III) and Parkinson´s disease (Paper IV). The findings of this thesis remarkably contribute to the proteomic and neurobiology fields and set phosphoproteomics as a powerful tool for the study of neuroscience.},
  author       = {Siino, Valentina},
  isbn         = {978-91-7753-610-9},
  keyword      = {Phosphoproteomics,mass spectrometry,brain disorders,neurobiology,phosphorylation},
  language     = {eng},
  publisher    = {Department of Immunotechnology, Lund University},
  school       = {Lund University},
  title        = {Phosphoproteomics to tackle brain disorders : Insight into the murine brain phosphoproteome},
  year         = {2018},
}