Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer

Clendenen, Tess ; Zeleniuch-Jacquotte, Anne ; Wirgin, Isaac ; Koenig, Karen L. ; Afanasyeva, Yelena ; Lundin, Eva ; Arslan, Alan A. ; Axelsson, Tomas ; Försti, Asta LU and Hallmans, Goran , et al. (2013) In PLoS ONE 8(7).
Abstract
Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationship between specific genetic variants in hormone-related genes and breast cancer risk. In total, 1164 cases and 2111 individually-matched controls were included in the study. We did not observe an association between potential functional genetic polymorphisms in the estrogen pathway, SHBG rs6259, ESR1 rs2234693, CYP19 rs10046 and rs4775936, and... (More)
Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationship between specific genetic variants in hormone-related genes and breast cancer risk. In total, 1164 cases and 2111 individually-matched controls were included in the study. We did not observe an association between potential functional genetic polymorphisms in the estrogen pathway, SHBG rs6259, ESR1 rs2234693, CYP19 rs10046 and rs4775936, and UGT1A1 rs8175347, or the progesterone pathway, PGR rs1042838, with the risk of breast cancer. Our results suggest that these genetic variants do not have a strong effect on breast cancer risk. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
8
issue
7
article number
e69367
publisher
Public Library of Science (PLoS)
external identifiers
  • wos:000325211000109
  • scopus:84880713567
  • pmid:23935996
ISSN
1932-6203
DOI
10.1371/journal.pone.0069367
language
English
LU publication?
yes
id
95d5b797-9c8e-454a-bd1e-c800ebd30528 (old id 4170521)
date added to LUP
2016-04-01 14:26:06
date last changed
2022-04-14 17:49:53
@article{95d5b797-9c8e-454a-bd1e-c800ebd30528,
  abstract     = {{Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationship between specific genetic variants in hormone-related genes and breast cancer risk. In total, 1164 cases and 2111 individually-matched controls were included in the study. We did not observe an association between potential functional genetic polymorphisms in the estrogen pathway, SHBG rs6259, ESR1 rs2234693, CYP19 rs10046 and rs4775936, and UGT1A1 rs8175347, or the progesterone pathway, PGR rs1042838, with the risk of breast cancer. Our results suggest that these genetic variants do not have a strong effect on breast cancer risk.}},
  author       = {{Clendenen, Tess and Zeleniuch-Jacquotte, Anne and Wirgin, Isaac and Koenig, Karen L. and Afanasyeva, Yelena and Lundin, Eva and Arslan, Alan A. and Axelsson, Tomas and Försti, Asta and Hallmans, Goran and Hemminki, Kari and Lenner, Per and Roy, Nirmal and Shore, Roy E. and Chen, Yu}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  number       = {{7}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer}},
  url          = {{https://lup.lub.lu.se/search/files/3975436/4587262.pdf}},
  doi          = {{10.1371/journal.pone.0069367}},
  volume       = {{8}},
  year         = {{2013}},
}