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Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer

Clendenen, Tess; Zeleniuch-Jacquotte, Anne; Wirgin, Isaac; Koenig, Karen L.; Afanasyeva, Yelena; Lundin, Eva; Arslan, Alan A.; Axelsson, Tomas; Försti, Asta LU and Hallmans, Goran, et al. (2013) In PLoS ONE 8(7).
Abstract
Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationship between specific genetic variants in hormone-related genes and breast cancer risk. In total, 1164 cases and 2111 individually-matched controls were included in the study. We did not observe an association between potential functional genetic polymorphisms in the estrogen pathway, SHBG rs6259, ESR1 rs2234693, CYP19 rs10046 and rs4775936, and... (More)
Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationship between specific genetic variants in hormone-related genes and breast cancer risk. In total, 1164 cases and 2111 individually-matched controls were included in the study. We did not observe an association between potential functional genetic polymorphisms in the estrogen pathway, SHBG rs6259, ESR1 rs2234693, CYP19 rs10046 and rs4775936, and UGT1A1 rs8175347, or the progesterone pathway, PGR rs1042838, with the risk of breast cancer. Our results suggest that these genetic variants do not have a strong effect on breast cancer risk. (Less)
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PLoS ONE
volume
8
issue
7
publisher
Public Library of Science
external identifiers
  • wos:000325211000109
  • scopus:84880713567
ISSN
1932-6203
DOI
10.1371/journal.pone.0069367
language
English
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yes
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95d5b797-9c8e-454a-bd1e-c800ebd30528 (old id 4170521)
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2013-12-06 12:28:52
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2019-08-07 02:34:36
@article{95d5b797-9c8e-454a-bd1e-c800ebd30528,
  abstract     = {Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationship between specific genetic variants in hormone-related genes and breast cancer risk. In total, 1164 cases and 2111 individually-matched controls were included in the study. We did not observe an association between potential functional genetic polymorphisms in the estrogen pathway, SHBG rs6259, ESR1 rs2234693, CYP19 rs10046 and rs4775936, and UGT1A1 rs8175347, or the progesterone pathway, PGR rs1042838, with the risk of breast cancer. Our results suggest that these genetic variants do not have a strong effect on breast cancer risk.},
  articleno    = {e69367},
  author       = {Clendenen, Tess and Zeleniuch-Jacquotte, Anne and Wirgin, Isaac and Koenig, Karen L. and Afanasyeva, Yelena and Lundin, Eva and Arslan, Alan A. and Axelsson, Tomas and Försti, Asta and Hallmans, Goran and Hemminki, Kari and Lenner, Per and Roy, Nirmal and Shore, Roy E. and Chen, Yu},
  issn         = {1932-6203},
  language     = {eng},
  number       = {7},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer},
  url          = {http://dx.doi.org/10.1371/journal.pone.0069367},
  volume       = {8},
  year         = {2013},
}