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Association between MAPT haplotype and memory function in patients with Parkinson's disease and healthy aging individuals

Winder-Rhodes, Sophie E; Hampshire, Adam; Rowe, James B; Peelle, Jonathan E; Robbins, Trevor W; Owen, Adrian M and Barker, Roger A LU (2015) In Neurobiology of Aging 36(3). p.28-1519
Abstract

Genetic variation is associated with differences in the function of the brain as well as its susceptibility to disease. The common H1 haplotypic variant of the microtubule-associated protein tau gene (MAPT) has been related to an increased risk for Parkinson's disease (PD). Furthermore, among PD patients, H1 homozygotes have an accelerated progression to dementia. We investigated the neurocognitive correlates of MAPT haplotypes using functional magnetic resonance imaging. Thirty-seven nondemented patients with PD (19 H1/H1, 18 H2 carriers) and 40 age-matched controls (21 H1/H1, 19 H2 carriers) were scanned during performance of a picture memory encoding task. Behaviorally, H1 homozygosity was associated with impaired picture recognition... (More)

Genetic variation is associated with differences in the function of the brain as well as its susceptibility to disease. The common H1 haplotypic variant of the microtubule-associated protein tau gene (MAPT) has been related to an increased risk for Parkinson's disease (PD). Furthermore, among PD patients, H1 homozygotes have an accelerated progression to dementia. We investigated the neurocognitive correlates of MAPT haplotypes using functional magnetic resonance imaging. Thirty-seven nondemented patients with PD (19 H1/H1, 18 H2 carriers) and 40 age-matched controls (21 H1/H1, 19 H2 carriers) were scanned during performance of a picture memory encoding task. Behaviorally, H1 homozygosity was associated with impaired picture recognition memory in PD patients and control subjects. These impairments in the H1 homozygotes were accompanied by an altered blood-oxygen level-dependent response in the medial temporal lobe during successful memory encoding. Additional age-related differences in blood-oxygen level-dependent response were observed in the medial temporal lobes of H1 homozygotes with PD. These results suggest that common variation in MAPT is not only associated with the dementia of PD but also differences in the neural circuitry underlying aspects of cognition in normal aging.

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published
keywords
Aged, Aging, Cognition, Disease Progression, Female, Genetic Association Studies, Genetic Predisposition to Disease, Haplotypes, Humans, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Oxygen, Parkinson Disease, Risk, Temporal Lobe, tau Proteins, Journal Article, Research Support, Non-U.S. Gov't
in
Neurobiology of Aging
volume
36
issue
3
pages
10 pages
publisher
Elsevier
external identifiers
  • scopus:84923532150
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2014.12.006
language
English
LU publication?
no
id
95e63376-0302-499d-92e0-37b9cf3aba4a
date added to LUP
2016-11-24 14:56:24
date last changed
2017-08-27 06:29:52
@article{95e63376-0302-499d-92e0-37b9cf3aba4a,
  abstract     = {<p>Genetic variation is associated with differences in the function of the brain as well as its susceptibility to disease. The common H1 haplotypic variant of the microtubule-associated protein tau gene (MAPT) has been related to an increased risk for Parkinson's disease (PD). Furthermore, among PD patients, H1 homozygotes have an accelerated progression to dementia. We investigated the neurocognitive correlates of MAPT haplotypes using functional magnetic resonance imaging. Thirty-seven nondemented patients with PD (19 H1/H1, 18 H2 carriers) and 40 age-matched controls (21 H1/H1, 19 H2 carriers) were scanned during performance of a picture memory encoding task. Behaviorally, H1 homozygosity was associated with impaired picture recognition memory in PD patients and control subjects. These impairments in the H1 homozygotes were accompanied by an altered blood-oxygen level-dependent response in the medial temporal lobe during successful memory encoding. Additional age-related differences in blood-oxygen level-dependent response were observed in the medial temporal lobes of H1 homozygotes with PD. These results suggest that common variation in MAPT is not only associated with the dementia of PD but also differences in the neural circuitry underlying aspects of cognition in normal aging.</p>},
  author       = {Winder-Rhodes, Sophie E and Hampshire, Adam and Rowe, James B and Peelle, Jonathan E and Robbins, Trevor W and Owen, Adrian M and Barker, Roger A},
  issn         = {1558-1497},
  keyword      = {Aged,Aging,Cognition,Disease Progression,Female,Genetic Association Studies,Genetic Predisposition to Disease,Haplotypes,Humans,Magnetic Resonance Imaging,Male,Memory,Middle Aged,Oxygen,Parkinson Disease,Risk,Temporal Lobe,tau Proteins,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {3},
  pages        = {28--1519},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {Association between MAPT haplotype and memory function in patients with Parkinson's disease and healthy aging individuals},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2014.12.006},
  volume       = {36},
  year         = {2015},
}