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A male bovine linkage map for the ADR granddaughter design

Thomsen, H. LU ; Reinsch, N.; Xu, N.; Looft, C.; Grupe, S.; Kühn, C.; Brockmann, G. A.; Schwerin, M.; Leyhe-Horn, B. and Hiendleder, S., et al. (2000) In Journal of Animal Breeding and Genetics 117(5). p.289-306
Abstract

The aim of this paper is to present the construction of a male genetic linkage map as a result of the bovine genome mapping project, which is a common effort of the German cattle breeding federation (ADR), four animal breeding institutes, three blood group laboratories and two animal data and breeding value evaluation centres. In total 20 grandsires with 1074 sires were provided from the German cattle population as reference families, 16 of these paternal half-sib groups are German Holstein families (DH), three are German Simmental (ST) families, and one is a Brown Swiss family (BS). Of 265 markers included in the linkage map, 248 were microsatellite markers, five were bovine blood group systems, eight SSCP markers and four proteins and... (More)

The aim of this paper is to present the construction of a male genetic linkage map as a result of the bovine genome mapping project, which is a common effort of the German cattle breeding federation (ADR), four animal breeding institutes, three blood group laboratories and two animal data and breeding value evaluation centres. In total 20 grandsires with 1074 sires were provided from the German cattle population as reference families, 16 of these paternal half-sib groups are German Holstein families (DH), three are German Simmental (ST) families, and one is a Brown Swiss family (BS). Of 265 markers included in the linkage map, 248 were microsatellite markers, five were bovine blood group systems, eight SSCP markers and four proteins and enzymes. More than 239 000 genotypes resulted from typing the offspring for the respective markers and these were used for the construction of the map. On average 478 informative meioses were provided from each marker of the map. The summarized map length over all chromosomes was 3135.1 cM with an average interval size of 13.34 CM. About 17, 35.7 and 79.1% of the map intervals showed a maximum genetic distance between the adjacent markers of 5,10 and 20 cM, respectively. The number of loci ranged from two (pseudoautosomal region of the sex chromosome, BTAY) to 15 (BTA23) with an average of 8.8 markers per chromosome. Comparing the length of the chromosomes shows variation from 49.6 cM for BTA26 to 190.5 CM for BTA1 with a mean of 107.7 cM for all autosomes of the genetic linkage map. It was possible to identify chromosomal discrepancies in locus order and map intervals by comparison with other published maps. The map provided sufficient marker density to serve as a useful tool for a scan of segregating quantitative trait loci.

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published
in
Journal of Animal Breeding and Genetics
volume
117
issue
5
pages
289 - 306
publisher
John Wiley & Sons
external identifiers
  • scopus:0034370901
ISSN
0931-2668
DOI
10.1046/j.1439-0388.2000.00263.x
language
English
LU publication?
no
id
960d34b6-ae96-4c59-ab0a-4092efb9908b
date added to LUP
2018-10-10 13:45:12
date last changed
2018-10-10 14:54:30
@article{960d34b6-ae96-4c59-ab0a-4092efb9908b,
  abstract     = {<p>The aim of this paper is to present the construction of a male genetic linkage map as a result of the bovine genome mapping project, which is a common effort of the German cattle breeding federation (ADR), four animal breeding institutes, three blood group laboratories and two animal data and breeding value evaluation centres. In total 20 grandsires with 1074 sires were provided from the German cattle population as reference families, 16 of these paternal half-sib groups are German Holstein families (DH), three are German Simmental (ST) families, and one is a Brown Swiss family (BS). Of 265 markers included in the linkage map, 248 were microsatellite markers, five were bovine blood group systems, eight SSCP markers and four proteins and enzymes. More than 239 000 genotypes resulted from typing the offspring for the respective markers and these were used for the construction of the map. On average 478 informative meioses were provided from each marker of the map. The summarized map length over all chromosomes was 3135.1 cM with an average interval size of 13.34 CM. About 17, 35.7 and 79.1% of the map intervals showed a maximum genetic distance between the adjacent markers of 5,10 and 20 cM, respectively. The number of loci ranged from two (pseudoautosomal region of the sex chromosome, BTAY) to 15 (BTA23) with an average of 8.8 markers per chromosome. Comparing the length of the chromosomes shows variation from 49.6 cM for BTA26 to 190.5 CM for BTA1 with a mean of 107.7 cM for all autosomes of the genetic linkage map. It was possible to identify chromosomal discrepancies in locus order and map intervals by comparison with other published maps. The map provided sufficient marker density to serve as a useful tool for a scan of segregating quantitative trait loci.</p>},
  author       = {Thomsen, H. and Reinsch, N. and Xu, N. and Looft, C. and Grupe, S. and Kühn, C. and Brockmann, G. A. and Schwerin, M. and Leyhe-Horn, B. and Hiendleder, S. and Erhardt, G. and Medjugorac, I. and Russ, I. and Förster, M. and Brenig, B. and Reinhardt, F. and Reents, R. and Blümel, J. and Averdunk, G. and Kalm, E.},
  issn         = {0931-2668},
  language     = {eng},
  month        = {01},
  number       = {5},
  pages        = {289--306},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Animal Breeding and Genetics},
  title        = {A male bovine linkage map for the ADR granddaughter design},
  url          = {http://dx.doi.org/10.1046/j.1439-0388.2000.00263.x},
  volume       = {117},
  year         = {2000},
}