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Bio-based starch nanoparticles with controlled size as antimicrobial agents nanocarriers

Morán, Diana ; Marefati, Ali LU ; Luque, Susana ; Schmidt, Marcus ; Rayner, Marilyn ; Blanco-López, María Carmen ; Gutiérrez, Gemma and Matos, María LU (2024) In Reactive and Functional Polymers 198.
Abstract

Starch nanoparticles (SNPs) have been synthesized by nanoprecipitation method using starches from different botanical sources in native form and modified with octenyl succinic anhydride (OSA). SNPs were characterized in terms of size, morphology, charge, XRPD, FTIR and thermal properties. Spherical particles were obtained with sizes ranging from 54 to 108 nm and zeta potential values from −2 to −27 mV. Changes in size and stability related to the % OSA were observed for each starch. Starch granules showed A-type crystalline pattern while a loss of crystallinity was observed for SNPs. FTIR spectra demonstrated that OSA modification was barely affected by the nanoprecipitation and SNPs showed thermal properties similar to those of starch... (More)

Starch nanoparticles (SNPs) have been synthesized by nanoprecipitation method using starches from different botanical sources in native form and modified with octenyl succinic anhydride (OSA). SNPs were characterized in terms of size, morphology, charge, XRPD, FTIR and thermal properties. Spherical particles were obtained with sizes ranging from 54 to 108 nm and zeta potential values from −2 to −27 mV. Changes in size and stability related to the % OSA were observed for each starch. Starch granules showed A-type crystalline pattern while a loss of crystallinity was observed for SNPs. FTIR spectra demonstrated that OSA modification was barely affected by the nanoprecipitation and SNPs showed thermal properties similar to those of starch granules. SNPs with specific size can be synthesized by selecting the appropriate starch granules as raw material. This is especially relevant in certain bio-applications, where size must be precisely controlled, e.g., as nanocarriers for drug release or food fortification. To investigate the feasibility of SNPs as nanocarriers, vanillin-loaded SNPs were synthesized, achieving encapsulation efficiencies of 30% and loading capacities of 60%. The antimicrobial activity of vanillin-loaded SNPs was tested against Escherichia Coli (E. coli) with satisfactory results.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Absolute ethanol (PubChem CID: 702), Antimicrobial, Controlled size, methanol (PubChem CID: 887), Nanocarriers, OSA modification, Starch nanoparticles, vanillin (PubChem CID: 1183)
in
Reactive and Functional Polymers
volume
198
article number
105881
publisher
Elsevier
external identifiers
  • scopus:85188027083
ISSN
1381-5148
DOI
10.1016/j.reactfunctpolym.2024.105881
language
English
LU publication?
yes
id
9614545b-2c68-4ff3-9e06-e62438bc8d31
date added to LUP
2024-04-04 11:11:25
date last changed
2024-04-09 14:29:25
@article{9614545b-2c68-4ff3-9e06-e62438bc8d31,
  abstract     = {{<p>Starch nanoparticles (SNPs) have been synthesized by nanoprecipitation method using starches from different botanical sources in native form and modified with octenyl succinic anhydride (OSA). SNPs were characterized in terms of size, morphology, charge, XRPD, FTIR and thermal properties. Spherical particles were obtained with sizes ranging from 54 to 108 nm and zeta potential values from −2 to −27 mV. Changes in size and stability related to the % OSA were observed for each starch. Starch granules showed A-type crystalline pattern while a loss of crystallinity was observed for SNPs. FTIR spectra demonstrated that OSA modification was barely affected by the nanoprecipitation and SNPs showed thermal properties similar to those of starch granules. SNPs with specific size can be synthesized by selecting the appropriate starch granules as raw material. This is especially relevant in certain bio-applications, where size must be precisely controlled, e.g., as nanocarriers for drug release or food fortification. To investigate the feasibility of SNPs as nanocarriers, vanillin-loaded SNPs were synthesized, achieving encapsulation efficiencies of 30% and loading capacities of 60%. The antimicrobial activity of vanillin-loaded SNPs was tested against Escherichia Coli (E. coli) with satisfactory results.</p>}},
  author       = {{Morán, Diana and Marefati, Ali and Luque, Susana and Schmidt, Marcus and Rayner, Marilyn and Blanco-López, María Carmen and Gutiérrez, Gemma and Matos, María}},
  issn         = {{1381-5148}},
  keywords     = {{Absolute ethanol (PubChem CID: 702); Antimicrobial; Controlled size; methanol (PubChem CID: 887); Nanocarriers; OSA modification; Starch nanoparticles; vanillin (PubChem CID: 1183)}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Reactive and Functional Polymers}},
  title        = {{Bio-based starch nanoparticles with controlled size as antimicrobial agents nanocarriers}},
  url          = {{http://dx.doi.org/10.1016/j.reactfunctpolym.2024.105881}},
  doi          = {{10.1016/j.reactfunctpolym.2024.105881}},
  volume       = {{198}},
  year         = {{2024}},
}