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Broad spectrum of time of detection, primary symptoms and disease progression in infants with HIV-1 infection

Naver, L ; Ehrnst, A ; Belfrage, E ; Blomberg, J ; Christensson, Bertil LU ; Forsgren, M ; Lidin-Janson, G ; Lindgren, S ; Ljung, Rolf LU orcid and Sonnerborg, A , et al. (2001) In European Journal of Clinical Microbiology & Infectious Diseases 20(3). p.159-166
Abstract
The relationship between time of HIV-1 detection, appearance of symptoms and disease progression was studied in all 24 HIV-1-infected infants from a cohort of 117 children who were born to HIV-1-infected mothers and monitored from birth. HIV isolation from plasma and mononuclear cells, HIV-1 DNA PCR (polymerase chain reaction) and, retrospectively, a quantitative assay for HIV-1 RNA were used for virus detection. Two infants possibly exhibited a symptomatic primary HIV infection. More children with than without symptoms during the first year of life progressed to immunological class 3 (P=0.013) and to AIDS or death (P=0.003) during follow-up. HIV-1 was detected within 4 days of age in 4 of 16 infants: 3 of them became symptomatic within 1... (More)
The relationship between time of HIV-1 detection, appearance of symptoms and disease progression was studied in all 24 HIV-1-infected infants from a cohort of 117 children who were born to HIV-1-infected mothers and monitored from birth. HIV isolation from plasma and mononuclear cells, HIV-1 DNA PCR (polymerase chain reaction) and, retrospectively, a quantitative assay for HIV-1 RNA were used for virus detection. Two infants possibly exhibited a symptomatic primary HIV infection. More children with than without symptoms during the first year of life progressed to immunological class 3 (P=0.013) and to AIDS or death (P=0.003) during follow-up. HIV-1 was detected within 4 days of age in 4 of 16 infants: 3 of them became symptomatic within 1 year, as did 6 of the remaining 12 infants (not statistically significant). All four infants in whom virus was detected within 4 days of age progressed to severe immunosuppression, compared to 6 of 14 in whom the virus detection test was initially negative prior to the first positive result (n.s.). Two children with previous repeatedly negative HIV detection tests were diagnosed with HIV-1 infection at 8 and 9 months, respectively. Repeated blood sampling is needed for the diagnosis of HIV-1 infection in perinatally exposed infants, and virus detection tests for exclusion of HIV-1 infection must be used with caution. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Clinical Microbiology & Infectious Diseases
volume
20
issue
3
pages
159 - 166
publisher
Springer
external identifiers
  • pmid:11347664
  • scopus:0035034457
ISSN
1435-4373
DOI
10.1007/s100960100454
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Infection Medicine (SUS) (013008000), Paediatric Hematologic Research Group (013243020)
id
9628dfa6-073b-47c8-bb43-b05b093c2310 (old id 1122905)
date added to LUP
2016-04-01 16:06:00
date last changed
2022-01-28 17:17:17
@article{9628dfa6-073b-47c8-bb43-b05b093c2310,
  abstract     = {{The relationship between time of HIV-1 detection, appearance of symptoms and disease progression was studied in all 24 HIV-1-infected infants from a cohort of 117 children who were born to HIV-1-infected mothers and monitored from birth. HIV isolation from plasma and mononuclear cells, HIV-1 DNA PCR (polymerase chain reaction) and, retrospectively, a quantitative assay for HIV-1 RNA were used for virus detection. Two infants possibly exhibited a symptomatic primary HIV infection. More children with than without symptoms during the first year of life progressed to immunological class 3 (P=0.013) and to AIDS or death (P=0.003) during follow-up. HIV-1 was detected within 4 days of age in 4 of 16 infants: 3 of them became symptomatic within 1 year, as did 6 of the remaining 12 infants (not statistically significant). All four infants in whom virus was detected within 4 days of age progressed to severe immunosuppression, compared to 6 of 14 in whom the virus detection test was initially negative prior to the first positive result (n.s.). Two children with previous repeatedly negative HIV detection tests were diagnosed with HIV-1 infection at 8 and 9 months, respectively. Repeated blood sampling is needed for the diagnosis of HIV-1 infection in perinatally exposed infants, and virus detection tests for exclusion of HIV-1 infection must be used with caution.}},
  author       = {{Naver, L and Ehrnst, A and Belfrage, E and Blomberg, J and Christensson, Bertil and Forsgren, M and Lidin-Janson, G and Lindgren, S and Ljung, Rolf and Sonnerborg, A and Bohlin, A B}},
  issn         = {{1435-4373}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{159--166}},
  publisher    = {{Springer}},
  series       = {{European Journal of Clinical Microbiology & Infectious Diseases}},
  title        = {{Broad spectrum of time of detection, primary symptoms and disease progression in infants with HIV-1 infection}},
  url          = {{http://dx.doi.org/10.1007/s100960100454}},
  doi          = {{10.1007/s100960100454}},
  volume       = {{20}},
  year         = {{2001}},
}