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Inhibition of TNF-alpha promoter activity and synthesis by A11-99-1, a new cyclopentenone from the ascomycete Mollisia melaleuca

Rether, J ; Erkel, G ; Sterner, Olov LU and Anke, T (2005) In Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences 60c(5-6). p.478-484
Abstract
In a search for inhibitors of the inducible tumor necrosis factor-alpha (TNF-alpha) promoter activity and synthesis, a new chlorinated cyclopentenone was isolated from fermentations of the ascomycete Mollisia melaleuca. The structure was determined by a combination of spectroscopic techniques. The compound blocked the inducible human TNF-alpha promoter activity and synthesis with IC50-values of 2.5-5 mu g/ml (8.1-16.1 mu M). Studies on the mode of action of the compound revealed that the inhibition of TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the I kappa B protein which prevents the activation of the transcription factor NF-kappa B. No cytotoxic, antibacterial and antifungal activities could be... (More)
In a search for inhibitors of the inducible tumor necrosis factor-alpha (TNF-alpha) promoter activity and synthesis, a new chlorinated cyclopentenone was isolated from fermentations of the ascomycete Mollisia melaleuca. The structure was determined by a combination of spectroscopic techniques. The compound blocked the inducible human TNF-alpha promoter activity and synthesis with IC50-values of 2.5-5 mu g/ml (8.1-16.1 mu M). Studies on the mode of action of the compound revealed that the inhibition of TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the I kappa B protein which prevents the activation of the transcription factor NF-kappa B. No cytotoxic, antibacterial and antifungal activities could be observed up to 100 mu g/ml (323 mu m) of the compound. (Less)
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type
Contribution to journal
publication status
published
subject
in
Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
volume
60c
issue
5-6
pages
478 - 484
publisher
Verlag der Zeitschrift für Naturforschung
external identifiers
  • wos:000231101200017
  • scopus:22144440946
ISSN
0939-5075
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
9641ee16-0ac3-4da0-81ee-d9a8f7c155e7 (old id 152379)
alternative location
http://www.znaturforsch.com/ac/v60c/60c0478.pdf
http://www.znaturforsch.com/ac/v60c/c60c.htm#No5
date added to LUP
2016-04-01 17:15:30
date last changed
2022-01-29 01:27:58
@article{9641ee16-0ac3-4da0-81ee-d9a8f7c155e7,
  abstract     = {{In a search for inhibitors of the inducible tumor necrosis factor-alpha (TNF-alpha) promoter activity and synthesis, a new chlorinated cyclopentenone was isolated from fermentations of the ascomycete Mollisia melaleuca. The structure was determined by a combination of spectroscopic techniques. The compound blocked the inducible human TNF-alpha promoter activity and synthesis with IC50-values of 2.5-5 mu g/ml (8.1-16.1 mu M). Studies on the mode of action of the compound revealed that the inhibition of TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the I kappa B protein which prevents the activation of the transcription factor NF-kappa B. No cytotoxic, antibacterial and antifungal activities could be observed up to 100 mu g/ml (323 mu m) of the compound.}},
  author       = {{Rether, J and Erkel, G and Sterner, Olov and Anke, T}},
  issn         = {{0939-5075}},
  language     = {{eng}},
  number       = {{5-6}},
  pages        = {{478--484}},
  publisher    = {{Verlag der Zeitschrift für Naturforschung}},
  series       = {{Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences}},
  title        = {{Inhibition of TNF-alpha promoter activity and synthesis by A11-99-1, a new cyclopentenone from the ascomycete Mollisia melaleuca}},
  url          = {{http://www.znaturforsch.com/ac/v60c/60c0478.pdf}},
  volume       = {{60c}},
  year         = {{2005}},
}