Advanced

Identification and characterization of frontal lobe degeneration - Historical perspective on the development of FTD

Brun, Arne LU (2007) In Alzheimer Disease and Associated Disorders 21(4). p.3-4
Abstract
This is a historical account of the development of the concept frontotemporal dementia, beginning with our discovery in the late 60s of a simple degenerative form. It was named frontal lobe degeneration of non-Alzheimer type to clearly separate it from the then almost totally dominating diagnosis Alzheimer disease. In the absence of immunohistochemical methods for specific disease markers, we had to rely solely on structural features. Later, from the 80s, the successively introduced methods to show glial acidic protein, tau, synaptophysin, ubiquitin, and other markers confirmed our impression of a simple type of degeneration. These methods also added further forms with additional features, and from the 90s genetics has contributed new... (More)
This is a historical account of the development of the concept frontotemporal dementia, beginning with our discovery in the late 60s of a simple degenerative form. It was named frontal lobe degeneration of non-Alzheimer type to clearly separate it from the then almost totally dominating diagnosis Alzheimer disease. In the absence of immunohistochemical methods for specific disease markers, we had to rely solely on structural features. Later, from the 80s, the successively introduced methods to show glial acidic protein, tau, synaptophysin, ubiquitin, and other markers confirmed our impression of a simple type of degeneration. These methods also added further forms with additional features, and from the 90s genetics has contributed new disease characteristics, all these advances leading up to the present conceptual structure of frontotemporal lobar degeneration. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
frontotemporal lobar degeneration, historical perspective
in
Alzheimer Disease and Associated Disorders
volume
21
issue
4
pages
3 - 4
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000251536500006
  • pmid:18090420
  • scopus:37349115519
ISSN
0893-0341
DOI
10.1097/WAD.0b013e31815bf511
language
English
LU publication?
yes
id
9073b901-cdeb-4f22-9a5b-6b8a1a770847 (old id 966212)
alternative location
http://www.alzheimerjournal.com/pt/re/adad/abstract.00002093-200710000-00007.htm
http://www.ncbi.nlm.nih.gov/pubmed/18090420?dopt=Abstract
date added to LUP
2008-01-29 13:44:51
date last changed
2017-01-01 07:12:05
@article{9073b901-cdeb-4f22-9a5b-6b8a1a770847,
  abstract     = {This is a historical account of the development of the concept frontotemporal dementia, beginning with our discovery in the late 60s of a simple degenerative form. It was named frontal lobe degeneration of non-Alzheimer type to clearly separate it from the then almost totally dominating diagnosis Alzheimer disease. In the absence of immunohistochemical methods for specific disease markers, we had to rely solely on structural features. Later, from the 80s, the successively introduced methods to show glial acidic protein, tau, synaptophysin, ubiquitin, and other markers confirmed our impression of a simple type of degeneration. These methods also added further forms with additional features, and from the 90s genetics has contributed new disease characteristics, all these advances leading up to the present conceptual structure of frontotemporal lobar degeneration.},
  author       = {Brun, Arne},
  issn         = {0893-0341},
  keyword      = {frontotemporal lobar degeneration,historical perspective},
  language     = {eng},
  number       = {4},
  pages        = {3--4},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Alzheimer Disease and Associated Disorders},
  title        = {Identification and characterization of frontal lobe degeneration - Historical perspective on the development of FTD},
  url          = {http://dx.doi.org/10.1097/WAD.0b013e31815bf511},
  volume       = {21},
  year         = {2007},
}