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Effect of ethanol on the excitability of the inferior olive in decerebrate ferret

Svensson, Pär LU ; Hesslow, Germund LU and Winton, Robert (1996) In Journal of Pharmacology and Experimental Therapeutics 277(2). p.761-767
Abstract

Climbing fibers, which originate in the inferior olive and project to Purkinje cells and Golgi cells in the cerebellar cortex, were activated at low (0.4-Hz) and high (4-Hz) frequencies by peri-orbital stimulation in decerebrate ferrets. Climbing fiber responses were recorded as field potentials from the c3 zone of the cerebellar surface. When periorbital stimulation was applied at high frequency, the climbing fiber responses became strongly depressed within a few seconds. It has previously been shown that this high frequency depression (HFD) of climbing fiber responses is due to a cerebellar inhibition of the inferior olive, probably via the nucleo- olivary pathway. Acute administration of ethanol had small and variable effects on the... (More)

Climbing fibers, which originate in the inferior olive and project to Purkinje cells and Golgi cells in the cerebellar cortex, were activated at low (0.4-Hz) and high (4-Hz) frequencies by peri-orbital stimulation in decerebrate ferrets. Climbing fiber responses were recorded as field potentials from the c3 zone of the cerebellar surface. When periorbital stimulation was applied at high frequency, the climbing fiber responses became strongly depressed within a few seconds. It has previously been shown that this high frequency depression (HFD) of climbing fiber responses is due to a cerebellar inhibition of the inferior olive, probably via the nucleo- olivary pathway. Acute administration of ethanol had small and variable effects on the amplitude of climbing fiber responses evoked by low-frequency stimulation. In contrast, medium concentrations (0.44-2.90 g/l) of ethanol led to a marked reduction of the HFD. Low (<0.44 g/l) systemic concentrations had no measurable effects on the HFD, whereas high concentrations (>2.90 g/l) caused either an increased HFD or a nonspecific reduction in olivary excitability. Because HFD has previously been shown to involve cerebello- olivary inhibition, the possibility of an interaction between ethanol and GABA-ergic responses in the interposito-olivary pathway is discussed.

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type
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publication status
published
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in
Journal of Pharmacology and Experimental Therapeutics
volume
277
issue
2
pages
761 - 767
publisher
American Society for Pharmacology and Experimental Therapeutics
external identifiers
  • pmid:8627556
  • scopus:0030430338
ISSN
0022-3565
language
English
LU publication?
yes
id
966e8d1e-1dca-4cd7-b3a5-85264fcb4674
alternative location
https://jpet.aspetjournals.org/content/277/2/761
date added to LUP
2022-05-16 11:20:56
date last changed
2024-01-11 17:32:58
@article{966e8d1e-1dca-4cd7-b3a5-85264fcb4674,
  abstract     = {{<p>Climbing fibers, which originate in the inferior olive and project to Purkinje cells and Golgi cells in the cerebellar cortex, were activated at low (0.4-Hz) and high (4-Hz) frequencies by peri-orbital stimulation in decerebrate ferrets. Climbing fiber responses were recorded as field potentials from the c3 zone of the cerebellar surface. When periorbital stimulation was applied at high frequency, the climbing fiber responses became strongly depressed within a few seconds. It has previously been shown that this high frequency depression (HFD) of climbing fiber responses is due to a cerebellar inhibition of the inferior olive, probably via the nucleo- olivary pathway. Acute administration of ethanol had small and variable effects on the amplitude of climbing fiber responses evoked by low-frequency stimulation. In contrast, medium concentrations (0.44-2.90 g/l) of ethanol led to a marked reduction of the HFD. Low (&lt;0.44 g/l) systemic concentrations had no measurable effects on the HFD, whereas high concentrations (&gt;2.90 g/l) caused either an increased HFD or a nonspecific reduction in olivary excitability. Because HFD has previously been shown to involve cerebello- olivary inhibition, the possibility of an interaction between ethanol and GABA-ergic responses in the interposito-olivary pathway is discussed.</p>}},
  author       = {{Svensson, Pär and Hesslow, Germund and Winton, Robert}},
  issn         = {{0022-3565}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{761--767}},
  publisher    = {{American Society for Pharmacology and Experimental Therapeutics}},
  series       = {{Journal of Pharmacology and Experimental Therapeutics}},
  title        = {{Effect of ethanol on the excitability of the inferior olive in decerebrate ferret}},
  url          = {{https://jpet.aspetjournals.org/content/277/2/761}},
  volume       = {{277}},
  year         = {{1996}},
}