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Investigation of the adsorption of PEG1500-12-acyloxystearate surfactants onto phospholipid bilayers: An ellipsometry and Cryo-TEM study

Vaccaro, Mauro LU ; von Corswant, Christian and Söderman, Olle LU (2007) In Biophysical Journal 93(12). p.4300-4306
Abstract
In this article we present a study of a new class of surfactants denoted as PEG1500-12-acyloxystearates, which have potential use as pharmaceutical solubilizers. These amphiphilic molecules present interesting properties with regard to cell damage effects. PEG1500-12-acyloxystearates with C-14 to C-16 acyloxy chains cause little or no damage to red blood and intestinal cells, whereas the surfactants with shorter chains, from C-8 to C-12, induce measurable damage. To start unraveling the reason why there is this rather marked dependence of the cell damage effect on surfactant chain length, we have carried out systematic studies of adsorption properties of the surfactants onto phospholipid bilayers by means of ellipsometry. The rate of... (More)
In this article we present a study of a new class of surfactants denoted as PEG1500-12-acyloxystearates, which have potential use as pharmaceutical solubilizers. These amphiphilic molecules present interesting properties with regard to cell damage effects. PEG1500-12-acyloxystearates with C-14 to C-16 acyloxy chains cause little or no damage to red blood and intestinal cells, whereas the surfactants with shorter chains, from C-8 to C-12, induce measurable damage. To start unraveling the reason why there is this rather marked dependence of the cell damage effect on surfactant chain length, we have carried out systematic studies of adsorption properties of the surfactants onto phospholipid bilayers by means of ellipsometry. The rate of incorporation of the surfactants in the lipid membrane decreases with increasing length of the acyloxy chain. Cryo-TEM images strengthen the ellipsometry results by showing that the dissolution of the phospholipid bilayer is slower for the surfactants of the series having longer chains. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biophysical Journal
volume
93
issue
12
pages
4300 - 4306
publisher
Cell Press
external identifiers
  • wos:000251298100023
  • scopus:37349010405
ISSN
1542-0086
DOI
10.1529/biophysj.107.109900
language
English
LU publication?
yes
id
6b892a35-f8f6-4b31-95be-48a2d0fd3b9e (old id 968712)
date added to LUP
2008-01-30 09:38:00
date last changed
2017-11-05 03:36:48
@article{6b892a35-f8f6-4b31-95be-48a2d0fd3b9e,
  abstract     = {In this article we present a study of a new class of surfactants denoted as PEG1500-12-acyloxystearates, which have potential use as pharmaceutical solubilizers. These amphiphilic molecules present interesting properties with regard to cell damage effects. PEG1500-12-acyloxystearates with C-14 to C-16 acyloxy chains cause little or no damage to red blood and intestinal cells, whereas the surfactants with shorter chains, from C-8 to C-12, induce measurable damage. To start unraveling the reason why there is this rather marked dependence of the cell damage effect on surfactant chain length, we have carried out systematic studies of adsorption properties of the surfactants onto phospholipid bilayers by means of ellipsometry. The rate of incorporation of the surfactants in the lipid membrane decreases with increasing length of the acyloxy chain. Cryo-TEM images strengthen the ellipsometry results by showing that the dissolution of the phospholipid bilayer is slower for the surfactants of the series having longer chains.},
  author       = {Vaccaro, Mauro and von Corswant, Christian and Söderman, Olle},
  issn         = {1542-0086},
  language     = {eng},
  number       = {12},
  pages        = {4300--4306},
  publisher    = {Cell Press},
  series       = {Biophysical Journal},
  title        = {Investigation of the adsorption of PEG1500-12-acyloxystearate surfactants onto phospholipid bilayers: An ellipsometry and Cryo-TEM study},
  url          = {http://dx.doi.org/10.1529/biophysj.107.109900},
  volume       = {93},
  year         = {2007},
}