Advanced

Investigation of X- and Y-specific single nucleotide polymorphisms in taurine (Bos taurus) and indicine (Bos indicus) cattle

Anderung, C.; Hellborg, Linda LU ; Seddon, J.; Hanotte, O. and Gotherstrom, A. (2007) In Animal Genetics 38(6). p.595-600
Abstract
Initially, domesticated African cattle were of taurine type. Today, we find both African Bos taurus and Bos indicus cattle, as well as their crossbreeds, on the continent of Africa and they all share the same set of African taurine mitochondrial DNA haplogroups. In this study, we report genetic variation as substitutions and insertions/deletions (indels) on both the X and Y chromosomes, and use the variation to assess hybridization between taurine and indicine cattle. Six African cattle breeds (four Sanga breeds, including Raya Azebu, Danakil, Caprivi, Nguni; and two Zebu breeds, including Kilimanjaro Zebu and South Kavirondo Zebu) were screened for six new X-chromosomal markers, specifically three single nucleotide polymorphisms and three... (More)
Initially, domesticated African cattle were of taurine type. Today, we find both African Bos taurus and Bos indicus cattle, as well as their crossbreeds, on the continent of Africa and they all share the same set of African taurine mitochondrial DNA haplogroups. In this study, we report genetic variation as substitutions and insertions/deletions (indels) on both the X and Y chromosomes, and use the variation to assess hybridization between taurine and indicine cattle. Six African cattle breeds (four Sanga breeds, including Raya Azebu, Danakil, Caprivi, Nguni; and two Zebu breeds, including Kilimanjaro Zebu and South Kavirondo Zebu) were screened for six new X-chromosomal markers, specifically three single nucleotide polymorphisms and three indels in the DDX3X (previously DBX) and ZFX genes, and five previously identified Y-chromosomal markers in the DDX3Y (previously DBY) and ZFY genes. In total, 90 (57 bulls and 33 cows) samples from the African breeds were analysed. We identify five diagnostic haplotypes of indicine and taurine origins on both the X and Y chromosomes. For each breed, the level of indicine introgression varies; in addition to pure taurine, indicine and hybrid X-chromosome individuals, recombinant X-chromosome variants were also detected. These markers are useful molecular tools for assessing the level of indicine admixture in African cattle breeds. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
X chromosome, Y chromosome, taurine, polymorphism, single nucleotide, introgression, indicine, indels, admixture, African
in
Animal Genetics
volume
38
issue
6
pages
595 - 600
publisher
Wiley-Blackwell
external identifiers
  • wos:000251327600007
  • scopus:36749062496
ISSN
1365-2052
DOI
10.1111/j.1365-2052.2007.01663.x
language
English
LU publication?
yes
id
e2be7a87-e198-4f20-bf1a-6ab53b7164f0 (old id 968722)
date added to LUP
2008-01-29 12:39:08
date last changed
2017-07-09 03:39:13
@article{e2be7a87-e198-4f20-bf1a-6ab53b7164f0,
  abstract     = {Initially, domesticated African cattle were of taurine type. Today, we find both African Bos taurus and Bos indicus cattle, as well as their crossbreeds, on the continent of Africa and they all share the same set of African taurine mitochondrial DNA haplogroups. In this study, we report genetic variation as substitutions and insertions/deletions (indels) on both the X and Y chromosomes, and use the variation to assess hybridization between taurine and indicine cattle. Six African cattle breeds (four Sanga breeds, including Raya Azebu, Danakil, Caprivi, Nguni; and two Zebu breeds, including Kilimanjaro Zebu and South Kavirondo Zebu) were screened for six new X-chromosomal markers, specifically three single nucleotide polymorphisms and three indels in the DDX3X (previously DBX) and ZFX genes, and five previously identified Y-chromosomal markers in the DDX3Y (previously DBY) and ZFY genes. In total, 90 (57 bulls and 33 cows) samples from the African breeds were analysed. We identify five diagnostic haplotypes of indicine and taurine origins on both the X and Y chromosomes. For each breed, the level of indicine introgression varies; in addition to pure taurine, indicine and hybrid X-chromosome individuals, recombinant X-chromosome variants were also detected. These markers are useful molecular tools for assessing the level of indicine admixture in African cattle breeds.},
  author       = {Anderung, C. and Hellborg, Linda and Seddon, J. and Hanotte, O. and Gotherstrom, A.},
  issn         = {1365-2052},
  keyword      = {X chromosome,Y chromosome,taurine,polymorphism,single nucleotide,introgression,indicine,indels,admixture,African},
  language     = {eng},
  number       = {6},
  pages        = {595--600},
  publisher    = {Wiley-Blackwell},
  series       = {Animal Genetics},
  title        = {Investigation of X- and Y-specific single nucleotide polymorphisms in taurine (Bos taurus) and indicine (Bos indicus) cattle},
  url          = {http://dx.doi.org/10.1111/j.1365-2052.2007.01663.x},
  volume       = {38},
  year         = {2007},
}