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Acute-phase proteins and incidence of diabetes : a population-based cohort study

Muhammad, Iram Faqir LU ; Borné, Yan LU ; Hedblad, Bo LU ; Nilsson, Peter M. LU ; Persson, Margaretha LU and Engström, Gunnar LU (2016) In Acta Diabetologica 53(6). p.981-989
Abstract

Aims: To examine the relationship between plasma levels of the acute-phase proteins ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin and C-reactive protein (CRP), and incidence of diabetes in the population-based Malmö Diet and Cancer Study—Cardiovascular Cohort (MDCS-CC). Methods: The study population consists of 4246 participants (aged 46–67 years, 60.8 % women) with no previous history of diabetes. Participants were followed, and incidence of diabetes was assessed by linkage with national registers and a clinical re-examination of the cohort. Cox proportional hazard regression analysis was used to compare incidence of diabetes in relation to sex-specific quartiles of the acute-phase proteins. Results: During a mean... (More)

Aims: To examine the relationship between plasma levels of the acute-phase proteins ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin and C-reactive protein (CRP), and incidence of diabetes in the population-based Malmö Diet and Cancer Study—Cardiovascular Cohort (MDCS-CC). Methods: The study population consists of 4246 participants (aged 46–67 years, 60.8 % women) with no previous history of diabetes. Participants were followed, and incidence of diabetes was assessed by linkage with national registers and a clinical re-examination of the cohort. Cox proportional hazard regression analysis was used to compare incidence of diabetes in relation to sex-specific quartiles of the acute-phase proteins. Results: During a mean follow-up period of 15.6 ± 3.4 years, a total of 390 participants were diagnosed with diabetes. Orosomucoid, haptoglobin, and CRP showed a significant increased risk of diabetes after adjustment for potential confounders. However, further adjustments for fasting glucose at baseline resulted in significant association only for CRP. The multivariable-adjusted hazard ratios (HR: 4th vs. 1st quartile) were 1.18 (95 % CI: 0.83–1.67; p = 0.51), 1.19 (CI: 0.85–1.62; p = 0.10), and 1.40 (CI: 1.01–1.95; p = 0.046) for orosomucoid, haptoglobin, and CRP respectively. Conclusion: The study demonstrated that there are associations between orosomucoid, haptoglobin and CRP and the risk of incidence of diabetes. However, after additional adjustment for fasting glucose levels at baseline, the association stayed significant only for CRP.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Acute-phase proteins, Alpha-1-antitrypsin, Ceruloplasmin, CRP, Diabetes, Haptoglobin, Incidence, Orosomucoid
in
Acta Diabetologica
volume
53
issue
6
pages
9 pages
publisher
Springer
external identifiers
  • scopus:84984823833
ISSN
0940-5429
DOI
10.1007/s00592-016-0903-8
language
English
LU publication?
yes
id
969eb32e-f88a-4147-b562-ff55e06688f9
date added to LUP
2016-09-21 10:15:28
date last changed
2017-01-02 14:12:31
@article{969eb32e-f88a-4147-b562-ff55e06688f9,
  abstract     = {<p>Aims: To examine the relationship between plasma levels of the acute-phase proteins ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin and C-reactive protein (CRP), and incidence of diabetes in the population-based Malmö Diet and Cancer Study—Cardiovascular Cohort (MDCS-CC). Methods: The study population consists of 4246 participants (aged 46–67 years, 60.8 % women) with no previous history of diabetes. Participants were followed, and incidence of diabetes was assessed by linkage with national registers and a clinical re-examination of the cohort. Cox proportional hazard regression analysis was used to compare incidence of diabetes in relation to sex-specific quartiles of the acute-phase proteins. Results: During a mean follow-up period of 15.6 ± 3.4 years, a total of 390 participants were diagnosed with diabetes. Orosomucoid, haptoglobin, and CRP showed a significant increased risk of diabetes after adjustment for potential confounders. However, further adjustments for fasting glucose at baseline resulted in significant association only for CRP. The multivariable-adjusted hazard ratios (HR: 4th vs. 1st quartile) were 1.18 (95 % CI: 0.83–1.67; p = 0.51), 1.19 (CI: 0.85–1.62; p = 0.10), and 1.40 (CI: 1.01–1.95; p = 0.046) for orosomucoid, haptoglobin, and CRP respectively. Conclusion: The study demonstrated that there are associations between orosomucoid, haptoglobin and CRP and the risk of incidence of diabetes. However, after additional adjustment for fasting glucose levels at baseline, the association stayed significant only for CRP.</p>},
  author       = {Muhammad, Iram Faqir and Borné, Yan and Hedblad, Bo and Nilsson, Peter M. and Persson, Margaretha and Engström, Gunnar},
  issn         = {0940-5429},
  keyword      = {Acute-phase proteins,Alpha-1-antitrypsin,Ceruloplasmin,CRP,Diabetes,Haptoglobin,Incidence,Orosomucoid},
  language     = {eng},
  month        = {08},
  number       = {6},
  pages        = {981--989},
  publisher    = {Springer},
  series       = {Acta Diabetologica},
  title        = {Acute-phase proteins and incidence of diabetes : a population-based cohort study},
  url          = {http://dx.doi.org/10.1007/s00592-016-0903-8},
  volume       = {53},
  year         = {2016},
}