Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice.
Liljedahl, Leena LU ; Norlin, Jenny ; McGuire, James Norton and James, Peter LU
(2017)
In Physiological Reports
5(6).
- Abstract
- Diabetes mellitus (DM) is a worldwide disease that affects 9% of the adult world population and type 2 DM accounts for 90% of those. A common consequence of DM is kidney complications, which could lead to kidney failure. We studied the potential effects of treatment with insulin and the glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide on the diabetic kidney proteome through the use of the db/db mouse model system and mass spectrometry (MS). Multivariate analyses revealed distinct effects of insulin and liraglutide on the db/db kidney proteome, which was seen on the protein levels of, for example, pterin-4 α-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor-1α (PCBD1), neural precursor cell expressed... (More)
- Diabetes mellitus (DM) is a worldwide disease that affects 9% of the adult world population and type 2 DM accounts for 90% of those. A common consequence of DM is kidney complications, which could lead to kidney failure. We studied the potential effects of treatment with insulin and the glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide on the diabetic kidney proteome through the use of the db/db mouse model system and mass spectrometry (MS). Multivariate analyses revealed distinct effects of insulin and liraglutide on the db/db kidney proteome, which was seen on the protein levels of, for example, pterin-4 α-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor-1α (PCBD1), neural precursor cell expressed developmentally down-regulated-8 (NEDD8), transcription elongation factor-B polypeptide-1 (ELOC) and hepcidin (HEPC). Furthermore, the separation of the insulin, liraglutide and vehicle db/db mouse groups in multivariate analyses was not mainly related to the albumin excretion rate (AER) or the level of glycated hemoglobin A1c (HbA1c%) in the mice. In summary, we show that insulin and liraglutide give rise to separate protein profiles in the db/db mouse kidney. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/96a197fb-d417-4f90-86fb-cd0875a5bdbc
- author
- Liljedahl, Leena
LU
; Norlin, Jenny
; McGuire, James Norton
and James, Peter
LU
- organization
- publishing date
- 2017-03-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- GLP‐1R agonist liraglutide, kidney proteome, OPLS‐DA, insulin
- in
- Physiological Reports
- volume
- 5
- issue
- 6
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85016269524
- ISSN
- 2051-817X
- DOI
- 10.14814/phy2.13187
- language
- English
- LU publication?
- yes
- id
- 96a197fb-d417-4f90-86fb-cd0875a5bdbc
- date added to LUP
- 2019-11-07 09:08:59
- date last changed
- 2023-09-23 17:52:55
@article{96a197fb-d417-4f90-86fb-cd0875a5bdbc,
abstract = {{Diabetes mellitus (DM) is a worldwide disease that affects 9% of the adult world population and type 2 DM accounts for 90% of those. A common consequence of DM is kidney complications, which could lead to kidney failure. We studied the potential effects of treatment with insulin and the glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide on the diabetic kidney proteome through the use of the db/db mouse model system and mass spectrometry (MS). Multivariate analyses revealed distinct effects of insulin and liraglutide on the db/db kidney proteome, which was seen on the protein levels of, for example, pterin-4 α-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor-1α (PCBD1), neural precursor cell expressed developmentally down-regulated-8 (NEDD8), transcription elongation factor-B polypeptide-1 (ELOC) and hepcidin (HEPC). Furthermore, the separation of the insulin, liraglutide and vehicle db/db mouse groups in multivariate analyses was not mainly related to the albumin excretion rate (AER) or the level of glycated hemoglobin A1c (HbA1c%) in the mice. In summary, we show that insulin and liraglutide give rise to separate protein profiles in the db/db mouse kidney.}},
author = {{Liljedahl, Leena and Norlin, Jenny and McGuire, James Norton and James, Peter}},
issn = {{2051-817X}},
keywords = {{GLP‐1R agonist liraglutide; kidney proteome; OPLS‐DA; insulin}},
language = {{eng}},
month = {{03}},
number = {{6}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Physiological Reports}},
title = {{Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice.}},
url = {{http://dx.doi.org/10.14814/phy2.13187}},
doi = {{10.14814/phy2.13187}},
volume = {{5}},
year = {{2017}},
}