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Cardiac biomarkers for detection of coronary artery disease in the community

Lind, Lars ; Alfredsson, Joakim ; Andersson, Jonas S O ; Andersson, Therese ; Bergström, Göran ; Ekblom, Örjan ; Fagman, Erika ; Fall, Tove LU ; Hagström, Emil and Isholth, Hannes Holm LU , et al. (2024) In Scientific Reports 14(1).
Abstract

To investigate whether coronary artery disease (CAD) burden is associated with plasma levels of the myocardial biomarkers Troponin I (TropI) and NT-proBNP in a large population-based sample using a cross-sectional design. Coronary computerized tomography (CT) angiography was performed in 25,859 subjects without a history of atherosclerotic disease from SCAPIS study (age 50-65, 52% women). TropI and NT-proBNP were measured in plasma. Segment involvement score (SIS) was the primary exposure and TropI the primary outcome. Both SIS and coronary artery calcium score, were associated with TropI levels following adjustment for age, sex and multiple confounders (p < 0.001), with similar relationships in men and women. Proximal segments from... (More)

To investigate whether coronary artery disease (CAD) burden is associated with plasma levels of the myocardial biomarkers Troponin I (TropI) and NT-proBNP in a large population-based sample using a cross-sectional design. Coronary computerized tomography (CT) angiography was performed in 25,859 subjects without a history of atherosclerotic disease from SCAPIS study (age 50-65, 52% women). TropI and NT-proBNP were measured in plasma. Segment involvement score (SIS) was the primary exposure and TropI the primary outcome. Both SIS and coronary artery calcium score, were associated with TropI levels following adjustment for age, sex and multiple confounders (p < 0.001), with similar relationships in men and women. Proximal segments from all three coronary arteries were related to TropI levels independently of one another. Adding TropI to traditional risk factors marginally increased discrimination of atherosclerosis as compared to risk factors alone (C-statistics + 0.0005, p = 0.014). SIS was related also to NT-proBNP levels, mainly in men, but with lower estimates than TropI. The burden of CAD was related to TropI levels in both men and women. All three major coronary arteries contributed to this relationship. Adding TropI to traditional risk factors resulted in only marginally improved discrimination of coronary atherosclerosis.

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Contribution to journal
publication status
published
subject
keywords
Humans, Female, Male, Middle Aged, Coronary Artery Disease/blood, Biomarkers/blood, Peptide Fragments/blood, Natriuretic Peptide, Brain/blood, Aged, Troponin I/blood, Cross-Sectional Studies, Coronary Angiography, Risk Factors, Computed Tomography Angiography, Coronary Vessels/diagnostic imaging
in
Scientific Reports
volume
14
issue
1
article number
30514
publisher
Nature Publishing Group
external identifiers
  • scopus:85212202088
  • pmid:39681613
ISSN
2045-2322
DOI
10.1038/s41598-024-82777-x
language
English
LU publication?
yes
additional info
© 2024. The Author(s).
id
97153b01-4954-4203-9f4b-632eb77bb799
date added to LUP
2024-12-22 17:10:28
date last changed
2025-08-18 22:58:53
@article{97153b01-4954-4203-9f4b-632eb77bb799,
  abstract     = {{<p>To investigate whether coronary artery disease (CAD) burden is associated with plasma levels of the myocardial biomarkers Troponin I (TropI) and NT-proBNP in a large population-based sample using a cross-sectional design. Coronary computerized tomography (CT) angiography was performed in 25,859 subjects without a history of atherosclerotic disease from SCAPIS study (age 50-65, 52% women). TropI and NT-proBNP were measured in plasma. Segment involvement score (SIS) was the primary exposure and TropI the primary outcome. Both SIS and coronary artery calcium score, were associated with TropI levels following adjustment for age, sex and multiple confounders (p &lt; 0.001), with similar relationships in men and women. Proximal segments from all three coronary arteries were related to TropI levels independently of one another. Adding TropI to traditional risk factors marginally increased discrimination of atherosclerosis as compared to risk factors alone (C-statistics + 0.0005, p = 0.014). SIS was related also to NT-proBNP levels, mainly in men, but with lower estimates than TropI. The burden of CAD was related to TropI levels in both men and women. All three major coronary arteries contributed to this relationship. Adding TropI to traditional risk factors resulted in only marginally improved discrimination of coronary atherosclerosis.</p>}},
  author       = {{Lind, Lars and Alfredsson, Joakim and Andersson, Jonas S O and Andersson, Therese and Bergström, Göran and Ekblom, Örjan and Fagman, Erika and Fall, Tove and Hagström, Emil and Isholth, Hannes Holm and Janzon, Magnus and Jernberg, Tomas and Katsoularis, Ioannis and Leander, Karin and Leósdóttir, Margrét and Magnusson, Martin and Malinovschi, Andrei and Rosengren, Annika and Gustav Smith, J and Spaak, Jonas and Svensson, Per and Söderberg, Stefan and Östgren, Carl Johan and Engström, Gunnar}},
  issn         = {{2045-2322}},
  keywords     = {{Humans; Female; Male; Middle Aged; Coronary Artery Disease/blood; Biomarkers/blood; Peptide Fragments/blood; Natriuretic Peptide, Brain/blood; Aged; Troponin I/blood; Cross-Sectional Studies; Coronary Angiography; Risk Factors; Computed Tomography Angiography; Coronary Vessels/diagnostic imaging}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Cardiac biomarkers for detection of coronary artery disease in the community}},
  url          = {{http://dx.doi.org/10.1038/s41598-024-82777-x}},
  doi          = {{10.1038/s41598-024-82777-x}},
  volume       = {{14}},
  year         = {{2024}},
}