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Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

Ray, Sandip ; Britschgi, Markus ; Herbert, Charles ; Takeda-Uchimura, Yoshiko ; Boxer, Adam ; Blennow, Kaj ; Friedman, Leah F. ; Galasko, Douglas R. ; Jutel, Marek and Karydas, Anna , et al. (2007) In Nature Medicine 13(11). p.1359-1362
Abstract
A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Medicine
volume
13
issue
11
pages
1359 - 1362
publisher
Nature Publishing Group
external identifiers
  • wos:000250736900029
  • scopus:35948933394
ISSN
1546-170X
DOI
10.1038/nm1653
language
English
LU publication?
yes
id
519597e4-e332-40b6-b2e4-518b85a56731 (old id 971816)
date added to LUP
2016-04-01 17:12:46
date last changed
2022-04-23 03:04:11
@article{519597e4-e332-40b6-b2e4-518b85a56731,
  abstract     = {{A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.}},
  author       = {{Ray, Sandip and Britschgi, Markus and Herbert, Charles and Takeda-Uchimura, Yoshiko and Boxer, Adam and Blennow, Kaj and Friedman, Leah F. and Galasko, Douglas R. and Jutel, Marek and Karydas, Anna and Kaye, Jeffrey A. and Leszek, Jerzy and Miller, Bruce L. and Minthon, Lennart and Quinn, Joseph F. and Rabinovici, Gil D. and Robinson, William H. and Sabbagh, Marwan N. and So, Yuen T. and Sparks, D. Larry and Tabaton, Massimo and Tinklenberg, Jared and Yesavage, Jerome A. and Tibshirani, Robert and Wyss-Coray, Tony}},
  issn         = {{1546-170X}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1359--1362}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Medicine}},
  title        = {{Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins}},
  url          = {{http://dx.doi.org/10.1038/nm1653}},
  doi          = {{10.1038/nm1653}},
  volume       = {{13}},
  year         = {{2007}},
}