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Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells.

Böiers, Charlotta LU ; Carrelha, Joana; Lutteropp, Michael; Luc, Sidinh LU ; Green, Joanna C A; Azzoni, Emanuele; Woll, Petter S; Mead, Adam J; Hultquist, Anne LU and Swiers, Gemma, et al. (2013) In Cell Stem Cell 13(5). p.535-548
Abstract
In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to... (More)
In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important lineage-commitment step in mammalian hematopoiesis. (Less)
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type
Contribution to journal
publication status
published
subject
in
Cell Stem Cell
volume
13
issue
5
pages
535 - 548
publisher
Cell Press
external identifiers
  • wos:000329571500007
  • pmid:24054998
  • scopus:85027937601
ISSN
1934-5909
DOI
10.1016/j.stem.2013.08.012
language
English
LU publication?
yes
id
9737163f-4baf-4db0-9ed7-507f53fe30bf (old id 4065547)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24054998?dopt=Abstract
date added to LUP
2013-10-03 21:10:59
date last changed
2019-02-20 02:17:04
@article{9737163f-4baf-4db0-9ed7-507f53fe30bf,
  abstract     = {In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important lineage-commitment step in mammalian hematopoiesis.},
  author       = {Böiers, Charlotta and Carrelha, Joana and Lutteropp, Michael and Luc, Sidinh and Green, Joanna C A and Azzoni, Emanuele and Woll, Petter S and Mead, Adam J and Hultquist, Anne and Swiers, Gemma and Perdiguero, Elisa Gomez and Macaulay, Iain C and Melchiori, Luca and Luis, Tiago C and Kharazi, Shabnam and Bouriez-Jones, Tiphaine and Deng, Qiaolin and Pontén, Annica and Atkinson, Deborah and Jensen, Christina and Sitnicka Quinn, Ewa and Geissmann, Frederic and Godin, Isabelle and Sandberg, Rickard and de Bruijn, Marella F T R and Jacobsen, Sten Eirik W},
  issn         = {1934-5909},
  language     = {eng},
  number       = {5},
  pages        = {535--548},
  publisher    = {Cell Press},
  series       = {Cell Stem Cell},
  title        = {Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells.},
  url          = {http://dx.doi.org/10.1016/j.stem.2013.08.012},
  volume       = {13},
  year         = {2013},
}