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Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer

Thompson, Alex ; Manning, Hugh ; Brydegaard, Mikkel LU ; Coda, Sergio ; Kennedy, Gordon ; Patalay, Rakesh ; Waitong-Braemming, Ulrika ; De Beule, Pieter ; Neil, Mark and Andersson-Engels, Stefan LU , et al. (2011) Optical Biopsy IX In Progress in Biomedical Optics and Imaging - Proceedings of SPIE 7895.
Abstract

We present the application of two fibre-optic-coupled time-resolved spectrofluorometers and a compact steady-state diffuse reflected light/fluorescence spectrometer to in vivo and ex vivo studies of skin cancer and osteoarthritis. In a clinical study of skin cancer, 27 lesions on 25 patients were investigated in vivo before surgical excision of the region measured. Preliminary analysis reveals a statistically significant decrease in the autofluorescence lifetime of basal cell carcinomas compared to neighbouring healthy tissue. A study of autofluorescence signals associated with the onset of osteoarthritis indicates autofluorescence lifetime changes associated with collagen degradation.

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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
diffuse reflectance, fibre probe, fluorescence, fluorescence lifetime, osteoarthritis, skin cancer, spectrometer
host publication
Optical Biopsy IX
series title
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
volume
7895
article number
78950G
conference name
Optical Biopsy IX
conference location
San Francisco, CA, United States
conference dates
2011-01-24 - 2011-01-26
external identifiers
  • scopus:79954510686
ISSN
1605-7422
ISBN
9780819484321
DOI
10.1117/12.875120
language
English
LU publication?
yes
id
975dea2a-010c-4026-86ea-c731f7ddb8ab
date added to LUP
2023-09-29 14:58:45
date last changed
2023-10-20 15:10:16
@inproceedings{975dea2a-010c-4026-86ea-c731f7ddb8ab,
  abstract     = {{<p>We present the application of two fibre-optic-coupled time-resolved spectrofluorometers and a compact steady-state diffuse reflected light/fluorescence spectrometer to in vivo and ex vivo studies of skin cancer and osteoarthritis. In a clinical study of skin cancer, 27 lesions on 25 patients were investigated in vivo before surgical excision of the region measured. Preliminary analysis reveals a statistically significant decrease in the autofluorescence lifetime of basal cell carcinomas compared to neighbouring healthy tissue. A study of autofluorescence signals associated with the onset of osteoarthritis indicates autofluorescence lifetime changes associated with collagen degradation.</p>}},
  author       = {{Thompson, Alex and Manning, Hugh and Brydegaard, Mikkel and Coda, Sergio and Kennedy, Gordon and Patalay, Rakesh and Waitong-Braemming, Ulrika and De Beule, Pieter and Neil, Mark and Andersson-Engels, Stefan and Itoh, Yoshifumi and Bendsøe, Niels and Dunsby, Christopher and Svanberg, Katarina and French, Paul M.}},
  booktitle    = {{Optical Biopsy IX}},
  isbn         = {{9780819484321}},
  issn         = {{1605-7422}},
  keywords     = {{diffuse reflectance; fibre probe; fluorescence; fluorescence lifetime; osteoarthritis; skin cancer; spectrometer}},
  language     = {{eng}},
  series       = {{Progress in Biomedical Optics and Imaging - Proceedings of SPIE}},
  title        = {{Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer}},
  url          = {{http://dx.doi.org/10.1117/12.875120}},
  doi          = {{10.1117/12.875120}},
  volume       = {{7895}},
  year         = {{2011}},
}