Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer
(2011) Optical Biopsy IX In Progress in Biomedical Optics and Imaging - Proceedings of SPIE 7895.- Abstract
We present the application of two fibre-optic-coupled time-resolved spectrofluorometers and a compact steady-state diffuse reflected light/fluorescence spectrometer to in vivo and ex vivo studies of skin cancer and osteoarthritis. In a clinical study of skin cancer, 27 lesions on 25 patients were investigated in vivo before surgical excision of the region measured. Preliminary analysis reveals a statistically significant decrease in the autofluorescence lifetime of basal cell carcinomas compared to neighbouring healthy tissue. A study of autofluorescence signals associated with the onset of osteoarthritis indicates autofluorescence lifetime changes associated with collagen degradation.
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https://lup.lub.lu.se/record/975dea2a-010c-4026-86ea-c731f7ddb8ab
- author
- organization
- publishing date
- 2011
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- diffuse reflectance, fibre probe, fluorescence, fluorescence lifetime, osteoarthritis, skin cancer, spectrometer
- host publication
- Optical Biopsy IX
- series title
- Progress in Biomedical Optics and Imaging - Proceedings of SPIE
- volume
- 7895
- article number
- 78950G
- conference name
- Optical Biopsy IX
- conference location
- San Francisco, CA, United States
- conference dates
- 2011-01-24 - 2011-01-26
- external identifiers
-
- scopus:79954510686
- ISSN
- 1605-7422
- ISBN
- 9780819484321
- DOI
- 10.1117/12.875120
- language
- English
- LU publication?
- yes
- id
- 975dea2a-010c-4026-86ea-c731f7ddb8ab
- date added to LUP
- 2023-09-29 14:58:45
- date last changed
- 2023-10-20 15:10:16
@inproceedings{975dea2a-010c-4026-86ea-c731f7ddb8ab, abstract = {{<p>We present the application of two fibre-optic-coupled time-resolved spectrofluorometers and a compact steady-state diffuse reflected light/fluorescence spectrometer to in vivo and ex vivo studies of skin cancer and osteoarthritis. In a clinical study of skin cancer, 27 lesions on 25 patients were investigated in vivo before surgical excision of the region measured. Preliminary analysis reveals a statistically significant decrease in the autofluorescence lifetime of basal cell carcinomas compared to neighbouring healthy tissue. A study of autofluorescence signals associated with the onset of osteoarthritis indicates autofluorescence lifetime changes associated with collagen degradation.</p>}}, author = {{Thompson, Alex and Manning, Hugh and Brydegaard, Mikkel and Coda, Sergio and Kennedy, Gordon and Patalay, Rakesh and Waitong-Braemming, Ulrika and De Beule, Pieter and Neil, Mark and Andersson-Engels, Stefan and Itoh, Yoshifumi and Bendsøe, Niels and Dunsby, Christopher and Svanberg, Katarina and French, Paul M.}}, booktitle = {{Optical Biopsy IX}}, isbn = {{9780819484321}}, issn = {{1605-7422}}, keywords = {{diffuse reflectance; fibre probe; fluorescence; fluorescence lifetime; osteoarthritis; skin cancer; spectrometer}}, language = {{eng}}, series = {{Progress in Biomedical Optics and Imaging - Proceedings of SPIE}}, title = {{Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer}}, url = {{http://dx.doi.org/10.1117/12.875120}}, doi = {{10.1117/12.875120}}, volume = {{7895}}, year = {{2011}}, }