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Drug use disorder and risk of incident and fatal prostate cancer among Swedish men : a nationwide epidemiological study

Dahlman, Disa LU ; Li, Xinjun LU ; Crump, Casey LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2022) In Cancer Causes and Control 33(2). p.213-222
Abstract

Purpose: Prostate cancer is the second most common cancer in men and a leading cause of cancer mortality worldwide. Men with drug use disorders (DUD) may potentially be at high risk for prostate cancer mortality because of delayed diagnosis and/or undertreatment. In this study, we aimed to investigate prostate cancer incidence, mortality, and stage at time of diagnosis among men with DUD compared to the general male population in Sweden. Methods: We performed a follow-up study based on Swedish national register data for the period January 1997–December 2016. The study was based on 1,361,532 men aged 50–75 years at inclusion, of whom 9,259 were registered with DUD. Cox regression analysis was used to compute adjusted hazard ratios (HRs)... (More)

Purpose: Prostate cancer is the second most common cancer in men and a leading cause of cancer mortality worldwide. Men with drug use disorders (DUD) may potentially be at high risk for prostate cancer mortality because of delayed diagnosis and/or undertreatment. In this study, we aimed to investigate prostate cancer incidence, mortality, and stage at time of diagnosis among men with DUD compared to the general male population in Sweden. Methods: We performed a follow-up study based on Swedish national register data for the period January 1997–December 2016. The study was based on 1,361,532 men aged 50–75 years at inclusion, of whom 9,259 were registered with DUD. Cox regression analysis was used to compute adjusted hazard ratios (HRs) for incident and fatal prostate cancer, and cancer stage at time of diagnosis, associated with DUD. Results: DUD was associated with a slightly increased risk of incident prostate cancer (HR: 1.07, 95% confidence interval [CI] 1.00–1.14, p = 0.048) and substantially higher risk of fatal prostate cancer (HR: 1.59, 95% CI 1.40–1.82, p < 0.001), adjusted for age, socioeconomic factors, and comorbidities related to tobacco smoking and alcohol use disorder. No association was found between DUD and prostate cancer stage at diagnosis. Conclusions: Men with DUD have an increased risk of fatal prostate cancer, possibly related to undertreatment in this patient population. Our findings should raise attention among medical staff and decision-makers towards a disadvantaged group of men in need of easily accessible prostate cancer evaluation and treatment.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Drug abuse, Epidemiology, Mortality, Prostate cancer, Sweden
in
Cancer Causes and Control
volume
33
issue
2
pages
213 - 222
publisher
Springer
external identifiers
  • pmid:34743253
  • scopus:85118574284
ISSN
0957-5243
DOI
10.1007/s10552-021-01513-2
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021, The Author(s).
id
9788b6e2-0f51-4fca-b198-b9414e75b466
date added to LUP
2021-12-02 11:25:56
date last changed
2024-06-15 21:51:05
@article{9788b6e2-0f51-4fca-b198-b9414e75b466,
  abstract     = {{<p>Purpose: Prostate cancer is the second most common cancer in men and a leading cause of cancer mortality worldwide. Men with drug use disorders (DUD) may potentially be at high risk for prostate cancer mortality because of delayed diagnosis and/or undertreatment. In this study, we aimed to investigate prostate cancer incidence, mortality, and stage at time of diagnosis among men with DUD compared to the general male population in Sweden. Methods: We performed a follow-up study based on Swedish national register data for the period January 1997–December 2016. The study was based on 1,361,532 men aged 50–75 years at inclusion, of whom 9,259 were registered with DUD. Cox regression analysis was used to compute adjusted hazard ratios (HRs) for incident and fatal prostate cancer, and cancer stage at time of diagnosis, associated with DUD. Results: DUD was associated with a slightly increased risk of incident prostate cancer (HR: 1.07, 95% confidence interval [CI] 1.00–1.14, p = 0.048) and substantially higher risk of fatal prostate cancer (HR: 1.59, 95% CI 1.40–1.82, p &lt; 0.001), adjusted for age, socioeconomic factors, and comorbidities related to tobacco smoking and alcohol use disorder. No association was found between DUD and prostate cancer stage at diagnosis. Conclusions: Men with DUD have an increased risk of fatal prostate cancer, possibly related to undertreatment in this patient population. Our findings should raise attention among medical staff and decision-makers towards a disadvantaged group of men in need of easily accessible prostate cancer evaluation and treatment.</p>}},
  author       = {{Dahlman, Disa and Li, Xinjun and Crump, Casey and Sundquist, Jan and Sundquist, Kristina}},
  issn         = {{0957-5243}},
  keywords     = {{Drug abuse; Epidemiology; Mortality; Prostate cancer; Sweden}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{213--222}},
  publisher    = {{Springer}},
  series       = {{Cancer Causes and Control}},
  title        = {{Drug use disorder and risk of incident and fatal prostate cancer among Swedish men : a nationwide epidemiological study}},
  url          = {{http://dx.doi.org/10.1007/s10552-021-01513-2}},
  doi          = {{10.1007/s10552-021-01513-2}},
  volume       = {{33}},
  year         = {{2022}},
}