Drug use disorder and risk of incident and fatal prostate cancer among Swedish men : a nationwide epidemiological study
(2022) In Cancer Causes and Control 33(2). p.213-222- Abstract
Purpose: Prostate cancer is the second most common cancer in men and a leading cause of cancer mortality worldwide. Men with drug use disorders (DUD) may potentially be at high risk for prostate cancer mortality because of delayed diagnosis and/or undertreatment. In this study, we aimed to investigate prostate cancer incidence, mortality, and stage at time of diagnosis among men with DUD compared to the general male population in Sweden. Methods: We performed a follow-up study based on Swedish national register data for the period January 1997–December 2016. The study was based on 1,361,532 men aged 50–75 years at inclusion, of whom 9,259 were registered with DUD. Cox regression analysis was used to compute adjusted hazard ratios (HRs)... (More)
Purpose: Prostate cancer is the second most common cancer in men and a leading cause of cancer mortality worldwide. Men with drug use disorders (DUD) may potentially be at high risk for prostate cancer mortality because of delayed diagnosis and/or undertreatment. In this study, we aimed to investigate prostate cancer incidence, mortality, and stage at time of diagnosis among men with DUD compared to the general male population in Sweden. Methods: We performed a follow-up study based on Swedish national register data for the period January 1997–December 2016. The study was based on 1,361,532 men aged 50–75 years at inclusion, of whom 9,259 were registered with DUD. Cox regression analysis was used to compute adjusted hazard ratios (HRs) for incident and fatal prostate cancer, and cancer stage at time of diagnosis, associated with DUD. Results: DUD was associated with a slightly increased risk of incident prostate cancer (HR: 1.07, 95% confidence interval [CI] 1.00–1.14, p = 0.048) and substantially higher risk of fatal prostate cancer (HR: 1.59, 95% CI 1.40–1.82, p < 0.001), adjusted for age, socioeconomic factors, and comorbidities related to tobacco smoking and alcohol use disorder. No association was found between DUD and prostate cancer stage at diagnosis. Conclusions: Men with DUD have an increased risk of fatal prostate cancer, possibly related to undertreatment in this patient population. Our findings should raise attention among medical staff and decision-makers towards a disadvantaged group of men in need of easily accessible prostate cancer evaluation and treatment.
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- author
- Dahlman, Disa LU ; Li, Xinjun LU ; Crump, Casey LU ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Drug abuse, Epidemiology, Mortality, Prostate cancer, Sweden
- in
- Cancer Causes and Control
- volume
- 33
- issue
- 2
- pages
- 213 - 222
- publisher
- Springer
- external identifiers
-
- scopus:85118574284
- pmid:34743253
- ISSN
- 0957-5243
- DOI
- 10.1007/s10552-021-01513-2
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021, The Author(s).
- id
- 9788b6e2-0f51-4fca-b198-b9414e75b466
- date added to LUP
- 2021-12-02 11:25:56
- date last changed
- 2024-09-22 06:51:01
@article{9788b6e2-0f51-4fca-b198-b9414e75b466, abstract = {{<p>Purpose: Prostate cancer is the second most common cancer in men and a leading cause of cancer mortality worldwide. Men with drug use disorders (DUD) may potentially be at high risk for prostate cancer mortality because of delayed diagnosis and/or undertreatment. In this study, we aimed to investigate prostate cancer incidence, mortality, and stage at time of diagnosis among men with DUD compared to the general male population in Sweden. Methods: We performed a follow-up study based on Swedish national register data for the period January 1997–December 2016. The study was based on 1,361,532 men aged 50–75 years at inclusion, of whom 9,259 were registered with DUD. Cox regression analysis was used to compute adjusted hazard ratios (HRs) for incident and fatal prostate cancer, and cancer stage at time of diagnosis, associated with DUD. Results: DUD was associated with a slightly increased risk of incident prostate cancer (HR: 1.07, 95% confidence interval [CI] 1.00–1.14, p = 0.048) and substantially higher risk of fatal prostate cancer (HR: 1.59, 95% CI 1.40–1.82, p < 0.001), adjusted for age, socioeconomic factors, and comorbidities related to tobacco smoking and alcohol use disorder. No association was found between DUD and prostate cancer stage at diagnosis. Conclusions: Men with DUD have an increased risk of fatal prostate cancer, possibly related to undertreatment in this patient population. Our findings should raise attention among medical staff and decision-makers towards a disadvantaged group of men in need of easily accessible prostate cancer evaluation and treatment.</p>}}, author = {{Dahlman, Disa and Li, Xinjun and Crump, Casey and Sundquist, Jan and Sundquist, Kristina}}, issn = {{0957-5243}}, keywords = {{Drug abuse; Epidemiology; Mortality; Prostate cancer; Sweden}}, language = {{eng}}, number = {{2}}, pages = {{213--222}}, publisher = {{Springer}}, series = {{Cancer Causes and Control}}, title = {{Drug use disorder and risk of incident and fatal prostate cancer among Swedish men : a nationwide epidemiological study}}, url = {{http://dx.doi.org/10.1007/s10552-021-01513-2}}, doi = {{10.1007/s10552-021-01513-2}}, volume = {{33}}, year = {{2022}}, }