Interstitial laser thermotherapy of adenocarcinoma transplanted into rat liver
(1997) In European Journal of Surgery 163(11). p.861-870- Abstract
Objective: To examine the effect of different temperatures and exposure times in interstitial laser thermotherapy. Design: Controlled laboratory study. Setting: University hospital, Sweden. Material: 48 male Wistar FU rats with dimethylhydrazine-induced adenocarcinoma transplanted into the liver. Intervention: Treatment was given with an Nd:YAG laser and a feedback system for temperature regulation. Light was delivered into the centre of the turnout and the feedback thermistor probe was placed 3 mm from the tumour margin. Rats were treated at steady-state temperatures at the feedback thermistor of 43, 46, or 50°C for 30 minutes, and at a steady-state temperature of 46°C at the feedback thermistor also for 10 and 20 minutes. Main outcome... (More)
Objective: To examine the effect of different temperatures and exposure times in interstitial laser thermotherapy. Design: Controlled laboratory study. Setting: University hospital, Sweden. Material: 48 male Wistar FU rats with dimethylhydrazine-induced adenocarcinoma transplanted into the liver. Intervention: Treatment was given with an Nd:YAG laser and a feedback system for temperature regulation. Light was delivered into the centre of the turnout and the feedback thermistor probe was placed 3 mm from the tumour margin. Rats were treated at steady-state temperatures at the feedback thermistor of 43, 46, or 50°C for 30 minutes, and at a steady-state temperature of 46°C at the feedback thermistor also for 10 and 20 minutes. Main outcome measurement: Tumour control as assessed 6 days after treatment using light microscopical examination including immunohistochemical determination of bromodeoxyuridine (BrdU) incorporation into DNA as a measure of cell viability. Results: Complete tumour necrosis was achieved in all rats treated for 30 minutes, in 6/8 rats treated for 10 minutes and in 6/8 rats treated for 20 minutes at 46°C. During steady-state thermotherapy, temperatures at the tumour margin were about 11°higher than at the feedback thermistor (range 54-61°C). The surrounding liver tissue also became necrotic so that the total necrosis volume exceeded the pretreatment tumour volume. Conclusion: Interstitial laser thermotherapy at temperatures ranging from 54-61°C at the tumour margin ensures total necrosis of a transplanted rat liver carcinoma provided that treatment is given for 30 minutes.
(Less)
- author
- Möller, Páll H. LU ; Ivarsson, Kjell LU ; Stenram, Unne LU ; Radnell, Monica and Tranberg, Karl Göran LU
- organization
- publishing date
- 1997-11-24
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Feedback control, Hyperthermia, Interstitial, Laser, Light penetration, Neoplasm
- in
- European Journal of Surgery
- volume
- 163
- issue
- 11
- pages
- 10 pages
- publisher
- Oxford University Press
- external identifiers
-
- scopus:0030716799
- pmid:9414047
- ISSN
- 1102-4151
- language
- English
- LU publication?
- yes
- id
- 9791da50-c57d-4672-8641-2f01b57c6926
- date added to LUP
- 2019-06-15 17:01:03
- date last changed
- 2024-01-01 10:46:01
@article{9791da50-c57d-4672-8641-2f01b57c6926,
abstract = {{<p>Objective: To examine the effect of different temperatures and exposure times in interstitial laser thermotherapy. Design: Controlled laboratory study. Setting: University hospital, Sweden. Material: 48 male Wistar FU rats with dimethylhydrazine-induced adenocarcinoma transplanted into the liver. Intervention: Treatment was given with an Nd:YAG laser and a feedback system for temperature regulation. Light was delivered into the centre of the turnout and the feedback thermistor probe was placed 3 mm from the tumour margin. Rats were treated at steady-state temperatures at the feedback thermistor of 43, 46, or 50°C for 30 minutes, and at a steady-state temperature of 46°C at the feedback thermistor also for 10 and 20 minutes. Main outcome measurement: Tumour control as assessed 6 days after treatment using light microscopical examination including immunohistochemical determination of bromodeoxyuridine (BrdU) incorporation into DNA as a measure of cell viability. Results: Complete tumour necrosis was achieved in all rats treated for 30 minutes, in 6/8 rats treated for 10 minutes and in 6/8 rats treated for 20 minutes at 46°C. During steady-state thermotherapy, temperatures at the tumour margin were about 11°higher than at the feedback thermistor (range 54-61°C). The surrounding liver tissue also became necrotic so that the total necrosis volume exceeded the pretreatment tumour volume. Conclusion: Interstitial laser thermotherapy at temperatures ranging from 54-61°C at the tumour margin ensures total necrosis of a transplanted rat liver carcinoma provided that treatment is given for 30 minutes.</p>}},
author = {{Möller, Páll H. and Ivarsson, Kjell and Stenram, Unne and Radnell, Monica and Tranberg, Karl Göran}},
issn = {{1102-4151}},
keywords = {{Feedback control; Hyperthermia; Interstitial; Laser; Light penetration; Neoplasm}},
language = {{eng}},
month = {{11}},
number = {{11}},
pages = {{861--870}},
publisher = {{Oxford University Press}},
series = {{European Journal of Surgery}},
title = {{Interstitial laser thermotherapy of adenocarcinoma transplanted into rat liver}},
volume = {{163}},
year = {{1997}},
}