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Lung bioengineering : advances and challenges in lung decellularization and recellularization

Uriarte, Juan J. ; Uhl, Franziska E. LU ; Rolandsson Enes, Sara E. LU orcid ; Pouliot, Robert A. and Weiss, Daniel J. (2018) In Current opinion in organ transplantation 23(6). p.673-678
Abstract

PURPOSE OF REVIEW: Bioengineering the lung based on its natural extracellular matrix (ECM) offers novel opportunities to overcome the shortage of donors, to reduce chronic allograft rejections, and to improve the median survival rate of transplanted patients. During the last decade, lung tissue engineering has advanced rapidly to combine scaffolds, cells, and biologically active molecules into functional tissues to restore or improve the lung's main function, gas exchange. This review will inspect the current progress in lung bioengineering using decellularized and recellularized lung scaffolds and highlight future challenges in the field.

RECENT FINDINGS: Lung decellularization and recellularization protocols have provided... (More)

PURPOSE OF REVIEW: Bioengineering the lung based on its natural extracellular matrix (ECM) offers novel opportunities to overcome the shortage of donors, to reduce chronic allograft rejections, and to improve the median survival rate of transplanted patients. During the last decade, lung tissue engineering has advanced rapidly to combine scaffolds, cells, and biologically active molecules into functional tissues to restore or improve the lung's main function, gas exchange. This review will inspect the current progress in lung bioengineering using decellularized and recellularized lung scaffolds and highlight future challenges in the field.

RECENT FINDINGS: Lung decellularization and recellularization protocols have provided researchers with tools to progress toward functional lung tissue engineering. However, there is continuous evolution and refinement particularly for optimization of lung recellularization. These further the possibility of developing a transplantable bioartificial lung.

SUMMARY: Bioengineering the lung using recellularized scaffolds could offer a curative option for patients with end-stage organ failure but its accomplishment remains unclear in the short-term. However, the state-of-the-art of techniques described in this review will increase our knowledge of the lung ECM and of chemical and mechanical cues which drive cell repopulation to improve the advances in lung regeneration and lung tissue engineering.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current opinion in organ transplantation
volume
23
issue
6
pages
6 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:30300330
  • scopus:85055847262
ISSN
1087-2418
DOI
10.1097/MOT.0000000000000584
language
English
LU publication?
yes
id
9794e485-725a-40b5-8c04-e35cb718aa3d
date added to LUP
2018-11-14 11:52:02
date last changed
2023-12-17 02:38:55
@article{9794e485-725a-40b5-8c04-e35cb718aa3d,
  abstract     = {{<p>PURPOSE OF REVIEW: Bioengineering the lung based on its natural extracellular matrix (ECM) offers novel opportunities to overcome the shortage of donors, to reduce chronic allograft rejections, and to improve the median survival rate of transplanted patients. During the last decade, lung tissue engineering has advanced rapidly to combine scaffolds, cells, and biologically active molecules into functional tissues to restore or improve the lung's main function, gas exchange. This review will inspect the current progress in lung bioengineering using decellularized and recellularized lung scaffolds and highlight future challenges in the field.</p><p>RECENT FINDINGS: Lung decellularization and recellularization protocols have provided researchers with tools to progress toward functional lung tissue engineering. However, there is continuous evolution and refinement particularly for optimization of lung recellularization. These further the possibility of developing a transplantable bioartificial lung.</p><p>SUMMARY: Bioengineering the lung using recellularized scaffolds could offer a curative option for patients with end-stage organ failure but its accomplishment remains unclear in the short-term. However, the state-of-the-art of techniques described in this review will increase our knowledge of the lung ECM and of chemical and mechanical cues which drive cell repopulation to improve the advances in lung regeneration and lung tissue engineering.</p>}},
  author       = {{Uriarte, Juan J. and Uhl, Franziska E. and Rolandsson Enes, Sara E. and Pouliot, Robert A. and Weiss, Daniel J.}},
  issn         = {{1087-2418}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{673--678}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Current opinion in organ transplantation}},
  title        = {{Lung bioengineering : advances and challenges in lung decellularization and recellularization}},
  url          = {{http://dx.doi.org/10.1097/MOT.0000000000000584}},
  doi          = {{10.1097/MOT.0000000000000584}},
  volume       = {{23}},
  year         = {{2018}},
}