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Analyses of the Effects of Wild-Type TDP-43 Overexpression in Oxytocin Neurons in Mice

Bergh, Sofia LU ; Simonsson, Oskar LU and Petersén, Åsa LU (2026) In Neuropathology and Applied Neurobiology 52(1).
Abstract

Selective TDP-43 overexpression in oxytocin neurons in the paraventricular nucleus of the hypothalamus causes a decrease in oxytocin-immunopositive cells compared to uninjected mice. AAV-mediated TDP-43 overexpression in oxytocin neurons does not appear to be a major driver of behavioural and metabolic phenotypes in mice.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
amyotrophic lateral sclerosis, frontotemporal dementia, hypothalamus, metabolism, oxytocin, TDP-43
in
Neuropathology and Applied Neurobiology
volume
52
issue
1
article number
e70059
publisher
Wiley-Blackwell
external identifiers
  • pmid:41563042
  • scopus:105028138204
ISSN
0305-1846
DOI
10.1111/nan.70059
language
English
LU publication?
yes
id
97fbf23d-40e9-4a33-9554-f5797944f7c0
date added to LUP
2026-02-19 11:26:23
date last changed
2026-02-20 03:00:07
@article{97fbf23d-40e9-4a33-9554-f5797944f7c0,
  abstract     = {{<p>Selective TDP-43 overexpression in oxytocin neurons in the paraventricular nucleus of the hypothalamus causes a decrease in oxytocin-immunopositive cells compared to uninjected mice. AAV-mediated TDP-43 overexpression in oxytocin neurons does not appear to be a major driver of behavioural and metabolic phenotypes in mice.</p>}},
  author       = {{Bergh, Sofia and Simonsson, Oskar and Petersén, Åsa}},
  issn         = {{0305-1846}},
  keywords     = {{amyotrophic lateral sclerosis; frontotemporal dementia; hypothalamus; metabolism; oxytocin; TDP-43}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Neuropathology and Applied Neurobiology}},
  title        = {{Analyses of the Effects of Wild-Type TDP-43 Overexpression in Oxytocin Neurons in Mice}},
  url          = {{http://dx.doi.org/10.1111/nan.70059}},
  doi          = {{10.1111/nan.70059}},
  volume       = {{52}},
  year         = {{2026}},
}