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The proto-oncogene transcription factor Ets1 regulates neural crest development through Histone Deacetylase 1 to mediate output of bone morphogenetic protein signaling.

Wang, Chengdong ; Kam, Richard Kin Ting ; Shi, Weili ; Xia, Yin ; Chen, Xiongfong ; Cao, Ying ; Sun, Jianmin LU ; Du, Yanzhi ; Lu, Gang and Chen, Zijiang , et al. (2015) In Journal of Biological Chemistry 290(36). p.21925-21938
Abstract
The neural crest (NC) is a transient, migratory cell population that differentiates into a large variety of tissues including craniofacial cartilage, melanocytes, and peripheral nervous system. NC is initially induced at the border of neural plate and non-neuralectoderm by balanced regulation of multiple signaling pathways, among which an intermediate bone morphogenetic protein (BMP) signaling is essential for NC formation. Ets1, a proto-oncogene playing important roles in tumor invasion, has also been implicated in delamination of NC cells. In this study, we investigated Ets1 function in NC formation using Xenopus. Overexpression of ets1 repressed NC formation through down-regulation of BMP signaling. Moreover, ets1 repressed the... (More)
The neural crest (NC) is a transient, migratory cell population that differentiates into a large variety of tissues including craniofacial cartilage, melanocytes, and peripheral nervous system. NC is initially induced at the border of neural plate and non-neuralectoderm by balanced regulation of multiple signaling pathways, among which an intermediate bone morphogenetic protein (BMP) signaling is essential for NC formation. Ets1, a proto-oncogene playing important roles in tumor invasion, has also been implicated in delamination of NC cells. In this study, we investigated Ets1 function in NC formation using Xenopus. Overexpression of ets1 repressed NC formation through down-regulation of BMP signaling. Moreover, ets1 repressed the BMP-responsive gene id3 that is essential for NC formation. Conversely, overexpression of id3 can partially rescue the phenotype of NC inhibition induced by ectopic ets1. Mechanistically, we found that Ets1 binds to id3 promoter as well as Histone Deacetylase 1 (HDAC1), suggesting that Ets1 recruits HDAC1 to the promoter of id3, thereby inducing Histone deacetylation of the id3 promoter. Thus, our studies indicate that Ets1 regulates NC formation through attenuating BMP signaling epigenetically. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Biological Chemistry
volume
290
issue
36
pages
21925 - 21938
publisher
American Society for Biochemistry and Molecular Biology
external identifiers
  • pmid:26198637
  • wos:000360968500014
  • scopus:84941309126
ISSN
1083-351X
DOI
10.1074/jbc.M115.644864
language
English
LU publication?
yes
id
984b6ec9-e0c8-4610-9ff0-bebc53060b58 (old id 7721680)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26198637?dopt=Abstract
date added to LUP
2016-04-01 10:54:55
date last changed
2025-04-04 15:08:28
@article{984b6ec9-e0c8-4610-9ff0-bebc53060b58,
  abstract     = {{The neural crest (NC) is a transient, migratory cell population that differentiates into a large variety of tissues including craniofacial cartilage, melanocytes, and peripheral nervous system. NC is initially induced at the border of neural plate and non-neuralectoderm by balanced regulation of multiple signaling pathways, among which an intermediate bone morphogenetic protein (BMP) signaling is essential for NC formation. Ets1, a proto-oncogene playing important roles in tumor invasion, has also been implicated in delamination of NC cells. In this study, we investigated Ets1 function in NC formation using Xenopus. Overexpression of ets1 repressed NC formation through down-regulation of BMP signaling. Moreover, ets1 repressed the BMP-responsive gene id3 that is essential for NC formation. Conversely, overexpression of id3 can partially rescue the phenotype of NC inhibition induced by ectopic ets1. Mechanistically, we found that Ets1 binds to id3 promoter as well as Histone Deacetylase 1 (HDAC1), suggesting that Ets1 recruits HDAC1 to the promoter of id3, thereby inducing Histone deacetylation of the id3 promoter. Thus, our studies indicate that Ets1 regulates NC formation through attenuating BMP signaling epigenetically.}},
  author       = {{Wang, Chengdong and Kam, Richard Kin Ting and Shi, Weili and Xia, Yin and Chen, Xiongfong and Cao, Ying and Sun, Jianmin and Du, Yanzhi and Lu, Gang and Chen, Zijiang and Chan, Wood Yee and Chan, Sun On and Deng, Yi and Zhao, Hui}},
  issn         = {{1083-351X}},
  language     = {{eng}},
  number       = {{36}},
  pages        = {{21925--21938}},
  publisher    = {{American Society for Biochemistry and Molecular Biology}},
  series       = {{Journal of Biological Chemistry}},
  title        = {{The proto-oncogene transcription factor Ets1 regulates neural crest development through Histone Deacetylase 1 to mediate output of bone morphogenetic protein signaling.}},
  url          = {{http://dx.doi.org/10.1074/jbc.M115.644864}},
  doi          = {{10.1074/jbc.M115.644864}},
  volume       = {{290}},
  year         = {{2015}},
}