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Outside in : Roles of complement in autophagy

King, Ben C. LU orcid ; Kulak, Klaudia LU ; Colineau, Lucie LU and Blom, Anna M. LU orcid (2021) In British Journal of Pharmacology 178(14). p.2786-2801
Abstract

The complement system is a well-characterized cascade of extracellular serum proteins that is activated by pathogens and unwanted waste material. Products of activated complement signal to the host cells via cell surface receptors, eliciting responses such as removal of the stimulus by phagocytosis. The complement system therefore functions as a warning system, resulting in removal of unwanted material. This review describes how extracellular activation of the complement system can also trigger autophagic responses within cells, up-regulating protective homeostatic autophagy in response to perceived stress, but also initiating targeted anti-microbial autophagy in order to kill intracellular cytoinvasive pathogens. In particular, we will... (More)

The complement system is a well-characterized cascade of extracellular serum proteins that is activated by pathogens and unwanted waste material. Products of activated complement signal to the host cells via cell surface receptors, eliciting responses such as removal of the stimulus by phagocytosis. The complement system therefore functions as a warning system, resulting in removal of unwanted material. This review describes how extracellular activation of the complement system can also trigger autophagic responses within cells, up-regulating protective homeostatic autophagy in response to perceived stress, but also initiating targeted anti-microbial autophagy in order to kill intracellular cytoinvasive pathogens. In particular, we will focus on recent discoveries that indicate that complement may also have roles in detection and autophagy-mediated disposal of unwanted materials within the intracellular environment. We therefore summarize the current evidence for complement involvement in autophagy, both by transducing signals across the cell membrane, as well as roles within the cellular environment.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Pharmacology
volume
178
issue
14
pages
16 pages
publisher
Wiley
external identifiers
  • scopus:85088554666
  • pmid:32621514
ISSN
0007-1188
DOI
10.1111/bph.15192
language
English
LU publication?
yes
id
9889686f-08d9-48a1-98fd-2886e86a2a61
date added to LUP
2020-08-05 10:37:41
date last changed
2024-04-17 13:17:11
@article{9889686f-08d9-48a1-98fd-2886e86a2a61,
  abstract     = {{<p>The complement system is a well-characterized cascade of extracellular serum proteins that is activated by pathogens and unwanted waste material. Products of activated complement signal to the host cells via cell surface receptors, eliciting responses such as removal of the stimulus by phagocytosis. The complement system therefore functions as a warning system, resulting in removal of unwanted material. This review describes how extracellular activation of the complement system can also trigger autophagic responses within cells, up-regulating protective homeostatic autophagy in response to perceived stress, but also initiating targeted anti-microbial autophagy in order to kill intracellular cytoinvasive pathogens. In particular, we will focus on recent discoveries that indicate that complement may also have roles in detection and autophagy-mediated disposal of unwanted materials within the intracellular environment. We therefore summarize the current evidence for complement involvement in autophagy, both by transducing signals across the cell membrane, as well as roles within the cellular environment.</p>}},
  author       = {{King, Ben C. and Kulak, Klaudia and Colineau, Lucie and Blom, Anna M.}},
  issn         = {{0007-1188}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{14}},
  pages        = {{2786--2801}},
  publisher    = {{Wiley}},
  series       = {{British Journal of Pharmacology}},
  title        = {{Outside in : Roles of complement in autophagy}},
  url          = {{http://dx.doi.org/10.1111/bph.15192}},
  doi          = {{10.1111/bph.15192}},
  volume       = {{178}},
  year         = {{2021}},
}