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Relationships Between Charlson Comorbidity Index Associated Biomarkers and Outcomes Among Participants in the Malmö Diet and Cancer Study

Wessman, Torgny LU ; Ruge, Toralph LU ; Carlsson, Axel Carl ; Wändell, Per LU ; Khoshnood, Ardavan LU orcid and Melander, Olle LU orcid (2024) In Biomarkers 28(8). p.722-730
Abstract

Introduction: The aim was to evaluate two biomarker scores trained to identify comorbidity burden in the prediction of specified chronic morbidities, and mortality in the general population.

Methods: Cardiovascular biomarkers were measured in the cardiovascular cohort of the Malmö Diet and Cancer Study. A score of 19 biomarkers associated with Charlson Comorbidity Index (CCI) was created (BSMDC). Individuals with CCI diagnoses and other major comorbidities were excluded. Another score of 11 biomarkers associated with comorbidity burden from a previous study of acute dyspnea was also created (BSADYS). The scores were prospectively evaluated for prediction of mortality, and some chronic diseases, using Cox Proportional Hazards... (More)

Introduction: The aim was to evaluate two biomarker scores trained to identify comorbidity burden in the prediction of specified chronic morbidities, and mortality in the general population.

Methods: Cardiovascular biomarkers were measured in the cardiovascular cohort of the Malmö Diet and Cancer Study. A score of 19 biomarkers associated with Charlson Comorbidity Index (CCI) was created (BSMDC). Individuals with CCI diagnoses and other major comorbidities were excluded. Another score of 11 biomarkers associated with comorbidity burden from a previous study of acute dyspnea was also created (BSADYS). The scores were prospectively evaluated for prediction of mortality, and some chronic diseases, using Cox Proportional Hazards Modell.

Results: Fully adjusted models showed that BSMDC was significantly associated per 1 SD increment of the score with incident COPD, 55%, and congestive heart failure, 32%; and with mortality, 33% cardiovascular, 91% respiratory, 30% cancer, and 45% with all-cause mortality. The BSADYS showed no association with these outcomes, after simultaneous inclusion of both biomarker scores to all the clinical covariates.

Conclusion: BSMDC shows strong prediction of morbidity and mortality in individuals free from comorbidities at baseline, and the results suggest that healthy individuals with high level of BSMDC would benefit from intense preventive actions.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarkers, Charlson comorbidity score, Malmö Diet and Cancer study, biomarkörer
in
Biomarkers
volume
28
issue
8
pages
722 - 730
publisher
Taylor & Francis
external identifiers
  • pmid:38133614
  • scopus:85181659667
ISSN
1366-5804
DOI
10.1080/1354750X.2023.2298651
language
English
LU publication?
yes
id
989cb66b-094b-4b61-b9a3-6eabd5c94688
date added to LUP
2023-12-27 01:35:35
date last changed
2025-01-15 19:10:43
@article{989cb66b-094b-4b61-b9a3-6eabd5c94688,
  abstract     = {{<p>Introduction: The aim was to evaluate two biomarker scores trained to identify comorbidity burden in the prediction of specified chronic morbidities, and mortality in the general population. <br/><br/>Methods: Cardiovascular biomarkers were measured in the cardiovascular cohort of the Malmö Diet and Cancer Study. A score of 19 biomarkers associated with Charlson Comorbidity Index (CCI) was created (BSMDC). Individuals with CCI diagnoses and other major comorbidities were excluded. Another score of 11 biomarkers associated with comorbidity burden from a previous study of acute dyspnea was also created (BSADYS). The scores were prospectively evaluated for prediction of mortality, and some chronic diseases, using Cox Proportional Hazards Modell.</p><p>Results: Fully adjusted models showed that BSMDC was significantly associated per 1 SD increment of the score with incident COPD, 55%, and congestive heart failure, 32%; and with mortality, 33% cardiovascular, 91% respiratory, 30% cancer, and 45% with all-cause mortality. The BSADYS showed no association with these outcomes, after simultaneous inclusion of both biomarker scores to all the clinical covariates.</p><p>Conclusion: BSMDC shows strong prediction of morbidity and mortality in individuals free from comorbidities at baseline, and the results suggest that healthy individuals with high level of BSMDC would benefit from intense preventive actions.</p>}},
  author       = {{Wessman, Torgny and Ruge, Toralph and Carlsson, Axel Carl and Wändell, Per and Khoshnood, Ardavan and Melander, Olle}},
  issn         = {{1366-5804}},
  keywords     = {{Biomarkers; Charlson comorbidity score; Malmö Diet and Cancer study; biomarkörer}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{8}},
  pages        = {{722--730}},
  publisher    = {{Taylor & Francis}},
  series       = {{Biomarkers}},
  title        = {{Relationships Between Charlson Comorbidity Index Associated Biomarkers and Outcomes Among Participants in the Malmö Diet and Cancer Study}},
  url          = {{http://dx.doi.org/10.1080/1354750X.2023.2298651}},
  doi          = {{10.1080/1354750X.2023.2298651}},
  volume       = {{28}},
  year         = {{2024}},
}