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Sexual differentiation and development

Giwercman, Y. L. LU and Nordenskjöld, A. (2006) p.266-272
Abstract

Normal sexual differentiation requires complex molecular events to take place in a precise order, and even though much knowledge has been gained in recent decades, further research is still needed to understand the pathogenesis of different disorders of sexual differentiation. For the clinician who is confronted with a child with sexual ambiguity, it is most important not to guess the sex but to initiate a proper diagnostic procedure, preferably done by a specialist team. Diagnosis generally requires a thorough clinical examination of the child and careful family history taking. The further diagnostic procedure includes cytogenetic hormonal and mutational analyses before sex assignment. Advances in molecular genetics are continuously... (More)

Normal sexual differentiation requires complex molecular events to take place in a precise order, and even though much knowledge has been gained in recent decades, further research is still needed to understand the pathogenesis of different disorders of sexual differentiation. For the clinician who is confronted with a child with sexual ambiguity, it is most important not to guess the sex but to initiate a proper diagnostic procedure, preferably done by a specialist team. Diagnosis generally requires a thorough clinical examination of the child and careful family history taking. The further diagnostic procedure includes cytogenetic hormonal and mutational analyses before sex assignment. Advances in molecular genetics are continuously providing tools for the detection of genetic defects and the primary diagnosis of intersex disorders. These methods may also be applied to prenatal diagnosis and carrier identification.

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Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Andrology for the Clinician
editor
Schill, Wolf-Bernhard ; Comhaire, Frank H and Hargreave, Timothy B
pages
266 - 272
publisher
Springer
external identifiers
  • scopus:84890217870
ISBN
3540231714
9783540231714
DOI
10.1007/3-540-33713-X_57
language
English
LU publication?
yes
id
989e3b08-4169-4871-a965-eea633fb257f
date added to LUP
2019-05-23 09:43:29
date last changed
2021-02-17 01:41:41
@inbook{989e3b08-4169-4871-a965-eea633fb257f,
  abstract     = {<p>Normal sexual differentiation requires complex molecular events to take place in a precise order, and even though much knowledge has been gained in recent decades, further research is still needed to understand the pathogenesis of different disorders of sexual differentiation. For the clinician who is confronted with a child with sexual ambiguity, it is most important not to guess the sex but to initiate a proper diagnostic procedure, preferably done by a specialist team. Diagnosis generally requires a thorough clinical examination of the child and careful family history taking. The further diagnostic procedure includes cytogenetic hormonal and mutational analyses before sex assignment. Advances in molecular genetics are continuously providing tools for the detection of genetic defects and the primary diagnosis of intersex disorders. These methods may also be applied to prenatal diagnosis and carrier identification.</p>},
  author       = {Giwercman, Y. L. and Nordenskjöld, A.},
  booktitle    = {Andrology for the Clinician},
  editor       = {Schill, Wolf-Bernhard and Comhaire, Frank H and Hargreave, Timothy B},
  isbn         = {3540231714},
  language     = {eng},
  month        = {12},
  pages        = {266--272},
  publisher    = {Springer},
  title        = {Sexual differentiation and development},
  url          = {http://dx.doi.org/10.1007/3-540-33713-X_57},
  doi          = {10.1007/3-540-33713-X_57},
  year         = {2006},
}