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Eukaryotic translation initiation factor 4F : functional properties and physiological role

Shuvalova, Ekaterina ; Al Sheikh, Walaa ; Shuvalov, Alexey ; Terenin, Ilya M. LU orcid and Alkalaeva, Elena (2025) In Nucleic Acids Research 53(22).
Abstract

Successful translation requires multiple protein factors with diverse specific activities. Initiation of translation is regarded as the most tightly regulated step of this process, controlled by numerous factors. Among these is the eukaryotic initiation factor 4F (eIF4F), a protein complex composed of three subunits: the cap-binding protein eIF4E, the RNA helicase eIF4A, and the scaffolding protein eIF4G. While significant progress has been made in elucidating the structure and functions of eIF4F, several key questions remain unresolved concerning its mechanistic contributions to translational control. In this review, we discuss the roles of eIF4F in translation and its regulatory functions under diverse cellular conditions.... (More)

Successful translation requires multiple protein factors with diverse specific activities. Initiation of translation is regarded as the most tightly regulated step of this process, controlled by numerous factors. Among these is the eukaryotic initiation factor 4F (eIF4F), a protein complex composed of three subunits: the cap-binding protein eIF4E, the RNA helicase eIF4A, and the scaffolding protein eIF4G. While significant progress has been made in elucidating the structure and functions of eIF4F, several key questions remain unresolved concerning its mechanistic contributions to translational control. In this review, we discuss the roles of eIF4F in translation and its regulatory functions under diverse cellular conditions. Dysregulation of eIF4F is frequently implicated in a wide range of physiological abnormalities, confirming its critical role in the cell. We also review recent studies that position eIF4F as a global cellular regulator and expand our understanding of its role.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nucleic Acids Research
volume
53
issue
22
article number
gkaf1351
publisher
Oxford University Press
external identifiers
  • pmid:41404795
  • scopus:105025062318
ISSN
0305-1048
DOI
10.1093/nar/gkaf1351
language
English
LU publication?
yes
additional info
Publisher Copyright: © The Author(s) 2025. Published by Oxford University Press.
id
98e27f88-cbb1-4624-a620-738c84c895cf
date added to LUP
2026-02-11 15:08:10
date last changed
2026-02-12 03:49:29
@article{98e27f88-cbb1-4624-a620-738c84c895cf,
  abstract     = {{<p>Successful translation requires multiple protein factors with diverse specific activities. Initiation of translation is regarded as the most tightly regulated step of this process, controlled by numerous factors. Among these is the eukaryotic initiation factor 4F (eIF4F), a protein complex composed of three subunits: the cap-binding protein eIF4E, the RNA helicase eIF4A, and the scaffolding protein eIF4G. While significant progress has been made in elucidating the structure and functions of eIF4F, several key questions remain unresolved concerning its mechanistic contributions to translational control. In this review, we discuss the roles of eIF4F in translation and its regulatory functions under diverse cellular conditions. Dysregulation of eIF4F is frequently implicated in a wide range of physiological abnormalities, confirming its critical role in the cell. We also review recent studies that position eIF4F as a global cellular regulator and expand our understanding of its role.</p>}},
  author       = {{Shuvalova, Ekaterina and Al Sheikh, Walaa and Shuvalov, Alexey and Terenin, Ilya M. and Alkalaeva, Elena}},
  issn         = {{0305-1048}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{22}},
  publisher    = {{Oxford University Press}},
  series       = {{Nucleic Acids Research}},
  title        = {{Eukaryotic translation initiation factor 4F : functional properties and physiological role}},
  url          = {{http://dx.doi.org/10.1093/nar/gkaf1351}},
  doi          = {{10.1093/nar/gkaf1351}},
  volume       = {{53}},
  year         = {{2025}},
}