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Islet cell related antibodies and type 1 diabetes associated with echovirus 30 epidemic : a case report

Cabrera-Rode, Eduardo ; Sarmiento, Luis LU orcid ; Molina, Gisela ; Pérez, Cecilia ; Arranz, Celeste ; Galvan, José A ; Prieto, Mirta ; Barrios, Julio ; Palomera, Rosa and Fonseca, Magile , et al. (2005) In Journal of Medical Virology 76(3). p.7-373
Abstract

Type 1 diabetes associated genes account for less than 50% of disease susceptibility. Human enteroviruses have been implicated as environmental factors that might trigger and/or accelerate this autoimmune disorder. We now report of a 12-year-old girl that developed pancreatic autoimmunity and type 1 diabetes after enteroviral infection. Diabetes-associated autoimmunity was evaluated by measurement of several islet cell related autoantibodies. Neutralizing antibodies to different enteroviruses were determined in the case and eight children suffering from aseptic meningitis during a large scale epidemic. Several types of diabetes-associated antibodies were detected post-infection in the adolescent with newly diagnosed type 1 diabetes,... (More)

Type 1 diabetes associated genes account for less than 50% of disease susceptibility. Human enteroviruses have been implicated as environmental factors that might trigger and/or accelerate this autoimmune disorder. We now report of a 12-year-old girl that developed pancreatic autoimmunity and type 1 diabetes after enteroviral infection. Diabetes-associated autoimmunity was evaluated by measurement of several islet cell related autoantibodies. Neutralizing antibodies to different enteroviruses were determined in the case and eight children suffering from aseptic meningitis during a large scale epidemic. Several types of diabetes-associated antibodies were detected post-infection in the adolescent with newly diagnosed type 1 diabetes, including islet cell antibodies (ICA) and tyrosine phosphatase antibodies (IA2A). ICA but not IA2A appeared in the non-diabetic enterovirus-infected subjects. Based on virological studies, type 1 diabetes pathogenesis process could have been triggered by echovirus 30 infections. This study provides the first evidence of an association between echovirus 30 infection with the presence of pancreatic autoimmunity and type 1 diabetes. Our data suggest that echovirus 30 Cuban strain could be considered a potentially diabetogenic enteroviral variant.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Arthritis, Infectious/blood, Autoantibodies/blood, Child, Child, Preschool, Cuba, Diabetes Mellitus, Type 1/etiology, Enterovirus Infections/complications, Female, Humans, Infant, Islets of Langerhans/immunology, Male, Neutralization Tests
in
Journal of Medical Virology
volume
76
issue
3
pages
5 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:15902705
  • scopus:20044363615
ISSN
0146-6615
DOI
10.1002/jmv.20368
language
English
LU publication?
no
additional info
Copyright (c) 2005 Wiley-Liss, Inc.
id
98e6040b-1697-4271-8bf2-755fc78994fb
date added to LUP
2019-07-08 14:51:45
date last changed
2024-05-29 23:18:50
@article{98e6040b-1697-4271-8bf2-755fc78994fb,
  abstract     = {{<p>Type 1 diabetes associated genes account for less than 50% of disease susceptibility. Human enteroviruses have been implicated as environmental factors that might trigger and/or accelerate this autoimmune disorder. We now report of a 12-year-old girl that developed pancreatic autoimmunity and type 1 diabetes after enteroviral infection. Diabetes-associated autoimmunity was evaluated by measurement of several islet cell related autoantibodies. Neutralizing antibodies to different enteroviruses were determined in the case and eight children suffering from aseptic meningitis during a large scale epidemic. Several types of diabetes-associated antibodies were detected post-infection in the adolescent with newly diagnosed type 1 diabetes, including islet cell antibodies (ICA) and tyrosine phosphatase antibodies (IA2A). ICA but not IA2A appeared in the non-diabetic enterovirus-infected subjects. Based on virological studies, type 1 diabetes pathogenesis process could have been triggered by echovirus 30 infections. This study provides the first evidence of an association between echovirus 30 infection with the presence of pancreatic autoimmunity and type 1 diabetes. Our data suggest that echovirus 30 Cuban strain could be considered a potentially diabetogenic enteroviral variant.</p>}},
  author       = {{Cabrera-Rode, Eduardo and Sarmiento, Luis and Molina, Gisela and Pérez, Cecilia and Arranz, Celeste and Galvan, José A and Prieto, Mirta and Barrios, Julio and Palomera, Rosa and Fonseca, Magile and Mas, Pedro and Díaz-Horta, Oscar and Diaz-Diaz, Oscar}},
  issn         = {{0146-6615}},
  keywords     = {{Adolescent; Arthritis, Infectious/blood; Autoantibodies/blood; Child; Child, Preschool; Cuba; Diabetes Mellitus, Type 1/etiology; Enterovirus Infections/complications; Female; Humans; Infant; Islets of Langerhans/immunology; Male; Neutralization Tests}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{7--373}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Journal of Medical Virology}},
  title        = {{Islet cell related antibodies and type 1 diabetes associated with echovirus 30 epidemic : a case report}},
  url          = {{http://dx.doi.org/10.1002/jmv.20368}},
  doi          = {{10.1002/jmv.20368}},
  volume       = {{76}},
  year         = {{2005}},
}