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Developmental changes in the brain-stem serotonergic nuclei of teleost fish and neural plasticity

Ekström, Peter LU (1994) In Cellular and Molecular Neurobiology 14(4). p.381-393
Abstract

1. During early ontogeny, the serotonergic neurons in the brain stem of the three-spined stickleback shows a temporal and spatial developmental pattern that closely resembles that of amniotes. 2. However, in the adult fish, only the midline nuclei of the rostral group (dorsal and median raphe nuclei) and the dorsal lateral tegmental nucleus are consistently serotonin-immunoreactive (5-HTir), whereas the groups of the upper and lower rhombencephalon (raphe pontis, raphe magnus, and raphe pallidus/obscurus nuclei) are variable and, when present, contain relatively small numbers of 5-HTir neurons. 3. Using specific antisera against tryptophan 5-hydroxylase and aromatic l-amino acid decarboxylase, we have shown that the lateral B9 group and... (More)

1. During early ontogeny, the serotonergic neurons in the brain stem of the three-spined stickleback shows a temporal and spatial developmental pattern that closely resembles that of amniotes. 2. However, in the adult fish, only the midline nuclei of the rostral group (dorsal and median raphe nuclei) and the dorsal lateral tegmental nucleus are consistently serotonin-immunoreactive (5-HTir), whereas the groups of the upper and lower rhombencephalon (raphe pontis, raphe magnus, and raphe pallidus/obscurus nuclei) are variable and, when present, contain relatively small numbers of 5-HTir neurons. 3. Using specific antisera against tryptophan 5-hydroxylase and aromatic l-amino acid decarboxylase, we have shown that the lateral B9 group and the groups of the upper and lower rhombencephalon are consistently present in adult sticklebacks. The results are discussed in relation to other known instances of neurotransmitter plasticity or transient neurotransmitter expression in teleost fish. 4. While there are several instances of transient expression of neurotransmitter markers by discrete neuronal populations, there is so far no evidence of changes from one neurotransmitter phenotype to another in the brain of teleost fish. However, there are indications of plasticity of expression of catecholamines and indoleamines, and their respective synthesizing enzymes, as reflected in age-dependent changes and variation between individuals of different physiological status. 5. As the brain grows continuously in teleost fish, and new neurons are added from proliferative regions, synaptic connections may be expected to undergo remodeling in all brain regions throughout life. Thus, the teleostean brain may be considered a suitable model for experimental studies of different aspects of neural plasticity.

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author
organization
publishing date
type
Contribution to journal
publication status
published
keywords
5-hydroxytryptamine, aromatic l-amino acid decarboxylase, Gasterosteus aculeatus, immunocytochemistry, Oncorhynchus kisutsch, Osteichtyes, serotonin, tryptophan 5-hydroxylase, tyrosine hydroxylase
in
Cellular and Molecular Neurobiology
volume
14
issue
4
pages
13 pages
publisher
Springer
external identifiers
  • scopus:0028625578
  • pmid:7788645
ISSN
0272-4340
DOI
10.1007/BF02088718
language
English
LU publication?
yes
id
98ee30f3-db78-4dbb-8b1f-b902babaf7db
date added to LUP
2019-10-02 14:48:48
date last changed
2019-11-25 09:35:01
@article{98ee30f3-db78-4dbb-8b1f-b902babaf7db,
  abstract     = {<p>1. During early ontogeny, the serotonergic neurons in the brain stem of the three-spined stickleback shows a temporal and spatial developmental pattern that closely resembles that of amniotes. 2. However, in the adult fish, only the midline nuclei of the rostral group (dorsal and median raphe nuclei) and the dorsal lateral tegmental nucleus are consistently serotonin-immunoreactive (5-HTir), whereas the groups of the upper and lower rhombencephalon (raphe pontis, raphe magnus, and raphe pallidus/obscurus nuclei) are variable and, when present, contain relatively small numbers of 5-HTir neurons. 3. Using specific antisera against tryptophan 5-hydroxylase and aromatic l-amino acid decarboxylase, we have shown that the lateral B9 group and the groups of the upper and lower rhombencephalon are consistently present in adult sticklebacks. The results are discussed in relation to other known instances of neurotransmitter plasticity or transient neurotransmitter expression in teleost fish. 4. While there are several instances of transient expression of neurotransmitter markers by discrete neuronal populations, there is so far no evidence of changes from one neurotransmitter phenotype to another in the brain of teleost fish. However, there are indications of plasticity of expression of catecholamines and indoleamines, and their respective synthesizing enzymes, as reflected in age-dependent changes and variation between individuals of different physiological status. 5. As the brain grows continuously in teleost fish, and new neurons are added from proliferative regions, synaptic connections may be expected to undergo remodeling in all brain regions throughout life. Thus, the teleostean brain may be considered a suitable model for experimental studies of different aspects of neural plasticity.</p>},
  author       = {Ekström, Peter},
  issn         = {0272-4340},
  language     = {eng},
  month        = {08},
  number       = {4},
  pages        = {381--393},
  publisher    = {Springer},
  series       = {Cellular and Molecular Neurobiology},
  title        = {Developmental changes in the brain-stem serotonergic nuclei of teleost fish and neural plasticity},
  url          = {http://dx.doi.org/10.1007/BF02088718},
  doi          = {10.1007/BF02088718},
  volume       = {14},
  year         = {1994},
}