Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon
Salehi, S Albert LU
; Qader, Saleem
LU
; Grapengiesser, Eva
and Hellman, Bo
(2007)
In Regulatory Peptides
144(1-3).
p.43-49
- Abstract
- It was early proposed that somatostatin-producing delta-cells in pancreatic islets have local inhibitory effects on the release of insulin and glucagon. Recent observations that pulses of insulin and glucagon are antisynchronous make it important to examine the temporal characteristics of glucose-induced somatostatin release. Analysis of 30 s fractions from the perfused rat pancreas indicated that increase of glucose from 3 to 20 mmol/l results in initial suppression of somatostatin release followed by regular 4-5 min pulses. During continued exposure to 20 mmol/l glucose, the pulses of somatostatin overlapped those of insulin with a delay of 30 s. Somatostatin and glucagon pulses were coupled in antisynchronous fashion (phase shift... (More)
- It was early proposed that somatostatin-producing delta-cells in pancreatic islets have local inhibitory effects on the release of insulin and glucagon. Recent observations that pulses of insulin and glucagon are antisynchronous make it important to examine the temporal characteristics of glucose-induced somatostatin release. Analysis of 30 s fractions from the perfused rat pancreas indicated that increase of glucose from 3 to 20 mmol/l results in initial suppression of somatostatin release followed by regular 4-5 min pulses. During continued exposure to 20 mmol/l glucose, the pulses of somatostatin overlapped those of insulin with a delay of 30 s. Somatostatin and glucagon pulses were coupled in antisynchronous fashion (phase shift 2.4+/-0.2 min), supporting the idea that the delta-cells have a local inhibitory effect on glucagon release. It was possible to remove the pulses of somatostatin and glucagon with maintenance of the insulin rhythmicity by addition of 1 mumol/l of the P2Y(1) receptor antagonist MRS 2179. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1138378
- author
- Salehi, S Albert
LU
; Qader, Saleem
LU
; Grapengiesser, Eva
and Hellman, Bo
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Pancreas perfusion, MRS 2179, Somatostatin pulse, Purinoceptor
- in
- Regulatory Peptides
- volume
- 144
- issue
- 1-3
- pages
- 43 - 49
- publisher
- Elsevier
- external identifiers
-
- pmid:17628719
- wos:000251601800007
- scopus:35648972696
- ISSN
- 1873-1686
- DOI
- 10.1016/j.regpep.2007.06.003
- language
- English
- LU publication?
- yes
- id
- 993bf119-7084-4b61-ad75-a895c2a0ab5b (old id 1138378)
- date added to LUP
- 2016-04-01 11:57:13
- date last changed
- 2022-01-26 20:38:28
@article{993bf119-7084-4b61-ad75-a895c2a0ab5b,
abstract = {{It was early proposed that somatostatin-producing delta-cells in pancreatic islets have local inhibitory effects on the release of insulin and glucagon. Recent observations that pulses of insulin and glucagon are antisynchronous make it important to examine the temporal characteristics of glucose-induced somatostatin release. Analysis of 30 s fractions from the perfused rat pancreas indicated that increase of glucose from 3 to 20 mmol/l results in initial suppression of somatostatin release followed by regular 4-5 min pulses. During continued exposure to 20 mmol/l glucose, the pulses of somatostatin overlapped those of insulin with a delay of 30 s. Somatostatin and glucagon pulses were coupled in antisynchronous fashion (phase shift 2.4+/-0.2 min), supporting the idea that the delta-cells have a local inhibitory effect on glucagon release. It was possible to remove the pulses of somatostatin and glucagon with maintenance of the insulin rhythmicity by addition of 1 mumol/l of the P2Y(1) receptor antagonist MRS 2179.}},
author = {{Salehi, S Albert and Qader, Saleem and Grapengiesser, Eva and Hellman, Bo}},
issn = {{1873-1686}},
keywords = {{Pancreas perfusion; MRS 2179; Somatostatin pulse; Purinoceptor}},
language = {{eng}},
number = {{1-3}},
pages = {{43--49}},
publisher = {{Elsevier}},
series = {{Regulatory Peptides}},
title = {{Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon}},
url = {{http://dx.doi.org/10.1016/j.regpep.2007.06.003}},
doi = {{10.1016/j.regpep.2007.06.003}},
volume = {{144}},
year = {{2007}},
}