The Colonic Vitamin D Receptor and Inflammatory Bowel Disease : No Correlation to Histologic or Endoscopic Inflammation
Bagger-Jörgensen, Harald LU ; Thomsen, Christian ; Borrisholt, Martine ; Wanders, Alkwin and Sjöberg, Klas LU
(2025)
In APMIS
133(1).
- Abstract
The role of the vitamin D receptor (VDR) in inflammatory bowel disease (IBD) is poorly described. The aim of this study was to examine the relationship between immunohistochemical VDR expression and IBD activity. The immunohistochemical expression of VDR was analysed in biopsies from active and inactive IBD in 28 patients (ulcerative colitis: 21, Crohn's disease: 7) and 12 non-IBD controls. VDR expression did not change in active compared to inactive disease (p = 0.40 in epithelium and p = 0.29 in stroma). There was a trend for higher VDR expression in controls compared to IBD patients. No relationship was found between VDR expression and histologic inflammation (r = −0.19, p = 0.89 for epithelium and r = 0.13, p = 0.35 for stroma),... (More)
The role of the vitamin D receptor (VDR) in inflammatory bowel disease (IBD) is poorly described. The aim of this study was to examine the relationship between immunohistochemical VDR expression and IBD activity. The immunohistochemical expression of VDR was analysed in biopsies from active and inactive IBD in 28 patients (ulcerative colitis: 21, Crohn's disease: 7) and 12 non-IBD controls. VDR expression did not change in active compared to inactive disease (p = 0.40 in epithelium and p = 0.29 in stroma). There was a trend for higher VDR expression in controls compared to IBD patients. No relationship was found between VDR expression and histologic inflammation (r = −0.19, p = 0.89 for epithelium and r = 0.13, p = 0.35 for stroma), colonoscopic picture and clinical and laboratory measures including serum 25(OH) vitamin D status (r = −0.91, p = 0.82). IBD disease activity did not correlate to VDR immunohistochemical expression, nor did it differ compared to controls. These results partly conflict with prior studies, but these have only shown modest correlations. Prospective studies investigating VDR activity between IBD and controls should be contemplated.
(Less)
- author
- Bagger-Jörgensen, Harald
LU
; Thomsen, Christian
; Borrisholt, Martine
; Wanders, Alkwin
and Sjöberg, Klas
LU
- organization
- publishing date
- 2025-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Crohn, inflammation, inflammatory bowel disease, ulcerative colitis, vitamin D receptor
- in
- APMIS
- volume
- 133
- issue
- 1
- article number
- e70000
- publisher
- Blackwell Munksgaard
- external identifiers
-
- scopus:85215587191
- pmid:39829252
- ISSN
- 0903-4641
- DOI
- 10.1111/apm.70000
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2025 The Author(s). APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Pathology, Medical Microbiology and Immunology.
- id
- 99414a30-bf5f-4365-8307-391d2f69651e
- date added to LUP
- 2025-04-23 11:17:17
- date last changed
- 2025-07-16 18:40:49
@article{99414a30-bf5f-4365-8307-391d2f69651e,
abstract = {{<p>The role of the vitamin D receptor (VDR) in inflammatory bowel disease (IBD) is poorly described. The aim of this study was to examine the relationship between immunohistochemical VDR expression and IBD activity. The immunohistochemical expression of VDR was analysed in biopsies from active and inactive IBD in 28 patients (ulcerative colitis: 21, Crohn's disease: 7) and 12 non-IBD controls. VDR expression did not change in active compared to inactive disease (p = 0.40 in epithelium and p = 0.29 in stroma). There was a trend for higher VDR expression in controls compared to IBD patients. No relationship was found between VDR expression and histologic inflammation (r = −0.19, p = 0.89 for epithelium and r = 0.13, p = 0.35 for stroma), colonoscopic picture and clinical and laboratory measures including serum 25(OH) vitamin D status (r = −0.91, p = 0.82). IBD disease activity did not correlate to VDR immunohistochemical expression, nor did it differ compared to controls. These results partly conflict with prior studies, but these have only shown modest correlations. Prospective studies investigating VDR activity between IBD and controls should be contemplated.</p>}},
author = {{Bagger-Jörgensen, Harald and Thomsen, Christian and Borrisholt, Martine and Wanders, Alkwin and Sjöberg, Klas}},
issn = {{0903-4641}},
keywords = {{Crohn; inflammation; inflammatory bowel disease; ulcerative colitis; vitamin D receptor}},
language = {{eng}},
number = {{1}},
publisher = {{Blackwell Munksgaard}},
series = {{APMIS}},
title = {{The Colonic Vitamin D Receptor and Inflammatory Bowel Disease : No Correlation to Histologic or Endoscopic Inflammation}},
url = {{http://dx.doi.org/10.1111/apm.70000}},
doi = {{10.1111/apm.70000}},
volume = {{133}},
year = {{2025}},
}