Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

A QTL for the degree of spotting in cattle shows synteny with the KIT locus on chromosome 6

Reinsch, Norbert ; Thomsen, H. LU orcid ; Xu, N. ; Brink, M. ; Looft, C. ; Kalm, E. ; Brockmann, G. A. ; Grupe, S. ; Kühn, C. and Schwerin, M. , et al. (1999) In Journal of Heredity 90(6). p.629-634
Abstract

The proportion of unpigmented coat on the trunk was determined from photographs of 38 German Simmental and 627 German Holstein bulls distributed over three generations. All 665 animals were members of 18 Holstein and 3 Simmental half-sib families. A Bayesian estimation of heritability yielded a posterior mean of 0.88 and a standard error of 0.08. A quantitative trait loci (QTL) scan over all chromosomes covered by 229 microsatellite marker loci (2926 cM) was performed by fitting a multiple marker regression model to 625 observations from the youngest generation in 18 families. On chromosome 6 a QTL for the proportion of white coat with large effects (experiment-wise error probability < .0001) was found and a less important one on... (More)

The proportion of unpigmented coat on the trunk was determined from photographs of 38 German Simmental and 627 German Holstein bulls distributed over three generations. All 665 animals were members of 18 Holstein and 3 Simmental half-sib families. A Bayesian estimation of heritability yielded a posterior mean of 0.88 and a standard error of 0.08. A quantitative trait loci (QTL) scan over all chromosomes covered by 229 microsatellite marker loci (2926 cM) was performed by fitting a multiple marker regression model to 625 observations from the youngest generation in 18 families. On chromosome 6 a QTL for the proportion of white coat with large effects (experiment-wise error probability < .0001) was found and a less important one on chromosome 3 (chromosome-wise error probability < .009). Chromosome 6 is known to harbor the KIT locus (receptor tyrosinase kinase), which is associated with various depigmentation phenotypes in mice, humans, and pigs. Similarity of phenotypic KIT effects in other species and synteny with the reported QTL suggest that KIT is a serious candidate gene for the degree of spotting in cattle. The results are also discussed with respect to resistance to solar radiation, heat stress, and photosensitization.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
in
Journal of Heredity
volume
90
issue
6
pages
6 pages
publisher
Oxford University Press
external identifiers
  • scopus:0032735314
  • pmid:10589513
ISSN
0022-1503
DOI
10.1093/jhered/90.6.629
language
English
LU publication?
no
id
9980cb73-d026-450c-863e-3fea147a9348
date added to LUP
2018-10-10 13:45:43
date last changed
2024-03-16 02:53:20
@article{9980cb73-d026-450c-863e-3fea147a9348,
  abstract     = {{<p>The proportion of unpigmented coat on the trunk was determined from photographs of 38 German Simmental and 627 German Holstein bulls distributed over three generations. All 665 animals were members of 18 Holstein and 3 Simmental half-sib families. A Bayesian estimation of heritability yielded a posterior mean of 0.88 and a standard error of 0.08. A quantitative trait loci (QTL) scan over all chromosomes covered by 229 microsatellite marker loci (2926 cM) was performed by fitting a multiple marker regression model to 625 observations from the youngest generation in 18 families. On chromosome 6 a QTL for the proportion of white coat with large effects (experiment-wise error probability &lt; .0001) was found and a less important one on chromosome 3 (chromosome-wise error probability &lt; .009). Chromosome 6 is known to harbor the KIT locus (receptor tyrosinase kinase), which is associated with various depigmentation phenotypes in mice, humans, and pigs. Similarity of phenotypic KIT effects in other species and synteny with the reported QTL suggest that KIT is a serious candidate gene for the degree of spotting in cattle. The results are also discussed with respect to resistance to solar radiation, heat stress, and photosensitization.</p>}},
  author       = {{Reinsch, Norbert and Thomsen, H. and Xu, N. and Brink, M. and Looft, C. and Kalm, E. and Brockmann, G. A. and Grupe, S. and Kühn, C. and Schwerin, M. and Leyhe, B. and Hiendleder, S. and Erhardt, G. and Medjugorac, I. and Russ, I. and Förster, M. and Reents, R. and Averdunk, G.}},
  issn         = {{0022-1503}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{6}},
  pages        = {{629--634}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of Heredity}},
  title        = {{A QTL for the degree of spotting in cattle shows synteny with the KIT locus on chromosome 6}},
  url          = {{http://dx.doi.org/10.1093/jhered/90.6.629}},
  doi          = {{10.1093/jhered/90.6.629}},
  volume       = {{90}},
  year         = {{1999}},
}