Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell Pool.
(2002) In Immunity 17(4). p.463-472- Abstract
- The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the... (More)
- The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/110578
- author
- Sitnicka Quinn, Ewa LU ; Bryder, David LU ; Theilgaard-Mönch, Kim ; Buza-Vidas, Natalija LU ; Adolfsson, Jörgen LU and Jacobsen, Sten Eirik W LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Immunity
- volume
- 17
- issue
- 4
- pages
- 463 - 472
- publisher
- Cell Press
- external identifiers
-
- pmid:12387740
- wos:000178667100007
- scopus:0036797682
- ISSN
- 1074-7613
- DOI
- 10.1016/S1074-7613(02)00419-3
- language
- English
- LU publication?
- yes
- id
- 99c2b32e-f9cf-4afb-8052-6d71d776ad00 (old id 110578)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12387740&dopt=Abstract
- date added to LUP
- 2016-04-01 11:58:21
- date last changed
- 2022-08-06 03:37:25
@article{99c2b32e-f9cf-4afb-8052-6d71d776ad00,
abstract = {{The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC.}},
author = {{Sitnicka Quinn, Ewa and Bryder, David and Theilgaard-Mönch, Kim and Buza-Vidas, Natalija and Adolfsson, Jörgen and Jacobsen, Sten Eirik W}},
issn = {{1074-7613}},
language = {{eng}},
number = {{4}},
pages = {{463--472}},
publisher = {{Cell Press}},
series = {{Immunity}},
title = {{Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell Pool.}},
url = {{http://dx.doi.org/10.1016/S1074-7613(02)00419-3}},
doi = {{10.1016/S1074-7613(02)00419-3}},
volume = {{17}},
year = {{2002}},
}