A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes
(2020) In Journal of Diabetes Research 2020(7814628).- Abstract
- The role of mitochondria in apoptosis is well known; however, the mechanisms linking mitochondria to the proapoptotic effects of proinflammatory cytokines, hyperglycemia, and glucolipotoxicity are not completely understood. Complex Ca2+ signaling has emerged as a critical contributor to these proapoptotic effects and has gained significant attention in regulating the signaling processes of mitochondria. In pancreatic β-cells, Ca2+ plays an active role in β-cell function and survival. Prohibitin (PHB), a mitochondrial chaperone, is actively involved in maintaining the architecture of mitochondria. However, its possible interaction with Ca2+-activated signaling pathways has not been explored. The present review aims to examine potential... (More)
- The role of mitochondria in apoptosis is well known; however, the mechanisms linking mitochondria to the proapoptotic effects of proinflammatory cytokines, hyperglycemia, and glucolipotoxicity are not completely understood. Complex Ca2+ signaling has emerged as a critical contributor to these proapoptotic effects and has gained significant attention in regulating the signaling processes of mitochondria. In pancreatic β-cells, Ca2+ plays an active role in β-cell function and survival. Prohibitin (PHB), a mitochondrial chaperone, is actively involved in maintaining the architecture of mitochondria. However, its possible interaction with Ca2+-activated signaling pathways has not been explored. The present review aims to examine potential crosstalk between Ca2+ signaling and PHB function in pancreatic β-cells. Moreover, this review will focus on the effects of cytokines and glucolipotoxicity on Ca2+ signaling and its possible interaction with PHB. Improved understanding of this important mitochondrial protein may aid in the design of more targeted drugs to identify specific pathways involved with stress-induced dysfunction in the β-cell.
(Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/99fed591-d625-4cb5-abcb-f6ce3865d932
- author
- Verma, Gaurav LU ; Dixit, Aparna and Nunemaker, Craig
- organization
- publishing date
- 2020-10-08
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Diabetes Research
- volume
- 2020
- issue
- 7814628
- article number
- 7814628
- pages
- 12 pages
- publisher
- Hindawi Limited
- external identifiers
-
- scopus:85099076081
- pmid:33354575
- ISSN
- 2314-6753
- DOI
- 10.1155/2020/7814628
- language
- English
- LU publication?
- yes
- id
- 99fed591-d625-4cb5-abcb-f6ce3865d932
- date added to LUP
- 2020-11-24 15:34:14
- date last changed
- 2022-04-19 02:19:24
@article{99fed591-d625-4cb5-abcb-f6ce3865d932, abstract = {{The role of mitochondria in apoptosis is well known; however, the mechanisms linking mitochondria to the proapoptotic effects of proinflammatory cytokines, hyperglycemia, and glucolipotoxicity are not completely understood. Complex Ca2+ signaling has emerged as a critical contributor to these proapoptotic effects and has gained significant attention in regulating the signaling processes of mitochondria. In pancreatic β-cells, Ca2+ plays an active role in β-cell function and survival. Prohibitin (PHB), a mitochondrial chaperone, is actively involved in maintaining the architecture of mitochondria. However, its possible interaction with Ca2+-activated signaling pathways has not been explored. The present review aims to examine potential crosstalk between Ca2+ signaling and PHB function in pancreatic β-cells. Moreover, this review will focus on the effects of cytokines and glucolipotoxicity on Ca2+ signaling and its possible interaction with PHB. Improved understanding of this important mitochondrial protein may aid in the design of more targeted drugs to identify specific pathways involved with stress-induced dysfunction in the β-cell.<br/><br/>}}, author = {{Verma, Gaurav and Dixit, Aparna and Nunemaker, Craig}}, issn = {{2314-6753}}, language = {{eng}}, month = {{10}}, number = {{7814628}}, publisher = {{Hindawi Limited}}, series = {{Journal of Diabetes Research}}, title = {{A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes}}, url = {{http://dx.doi.org/10.1155/2020/7814628}}, doi = {{10.1155/2020/7814628}}, volume = {{2020}}, year = {{2020}}, }