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A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes

Verma, Gaurav LU ; Dixit, Aparna and Nunemaker, Craig (2020) In Journal of Diabetes Research 2020(7814628).
Abstract
The role of mitochondria in apoptosis is well known; however, the mechanisms linking mitochondria to the proapoptotic effects of proinflammatory cytokines, hyperglycemia, and glucolipotoxicity are not completely understood. Complex Ca2+ signaling has emerged as a critical contributor to these proapoptotic effects and has gained significant attention in regulating the signaling processes of mitochondria. In pancreatic β-cells, Ca2+ plays an active role in β-cell function and survival. Prohibitin (PHB), a mitochondrial chaperone, is actively involved in maintaining the architecture of mitochondria. However, its possible interaction with Ca2+-activated signaling pathways has not been explored. The present review aims to examine potential... (More)
The role of mitochondria in apoptosis is well known; however, the mechanisms linking mitochondria to the proapoptotic effects of proinflammatory cytokines, hyperglycemia, and glucolipotoxicity are not completely understood. Complex Ca2+ signaling has emerged as a critical contributor to these proapoptotic effects and has gained significant attention in regulating the signaling processes of mitochondria. In pancreatic β-cells, Ca2+ plays an active role in β-cell function and survival. Prohibitin (PHB), a mitochondrial chaperone, is actively involved in maintaining the architecture of mitochondria. However, its possible interaction with Ca2+-activated signaling pathways has not been explored. The present review aims to examine potential crosstalk between Ca2+ signaling and PHB function in pancreatic β-cells. Moreover, this review will focus on the effects of cytokines and glucolipotoxicity on Ca2+ signaling and its possible interaction with PHB. Improved understanding of this important mitochondrial protein may aid in the design of more targeted drugs to identify specific pathways involved with stress-induced dysfunction in the β-cell.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Diabetes Research
volume
2020
issue
7814628
article number
7814628
pages
12 pages
publisher
Hindawi Limited
external identifiers
  • scopus:85099076081
  • pmid:33354575
ISSN
2314-6753
DOI
10.1155/2020/7814628
language
English
LU publication?
yes
id
99fed591-d625-4cb5-abcb-f6ce3865d932
date added to LUP
2020-11-24 15:34:14
date last changed
2022-04-19 02:19:24
@article{99fed591-d625-4cb5-abcb-f6ce3865d932,
  abstract     = {{The role of mitochondria in apoptosis is well known; however, the mechanisms linking mitochondria to the proapoptotic effects of proinflammatory cytokines, hyperglycemia, and glucolipotoxicity are not completely understood. Complex Ca2+ signaling has emerged as a critical contributor to these proapoptotic effects and has gained significant attention in regulating the signaling processes of mitochondria. In pancreatic β-cells, Ca2+ plays an active role in β-cell function and survival. Prohibitin (PHB), a mitochondrial chaperone, is actively involved in maintaining the architecture of mitochondria. However, its possible interaction with Ca2+-activated signaling pathways has not been explored. The present review aims to examine potential crosstalk between Ca2+ signaling and PHB function in pancreatic β-cells. Moreover, this review will focus on the effects of cytokines and glucolipotoxicity on Ca2+ signaling and its possible interaction with PHB. Improved understanding of this important mitochondrial protein may aid in the design of more targeted drugs to identify specific pathways involved with stress-induced dysfunction in the β-cell.<br/><br/>}},
  author       = {{Verma, Gaurav and Dixit, Aparna and Nunemaker, Craig}},
  issn         = {{2314-6753}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{7814628}},
  publisher    = {{Hindawi Limited}},
  series       = {{Journal of Diabetes Research}},
  title        = {{A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes}},
  url          = {{http://dx.doi.org/10.1155/2020/7814628}},
  doi          = {{10.1155/2020/7814628}},
  volume       = {{2020}},
  year         = {{2020}},
}