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Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging

Jarnum, Hanna ; Steffensen, Elena G. ; Knutsson, Linda LU orcid ; Frund, Ernst-Torben ; Simonsen, Carsten Wiberg ; Lundbye-Christensen, Soren ; Shankaranarayanan, Ajit ; Alsop, David C. ; Jensen, Finn Taagehoj and Larsson, Elna-Marie (2010) In Neuroradiology 52(4). p.307-317
Abstract
The purpose of this study was to compare the non-invasive 3D pseudo-continuous arterial spin labelling (PC ASL) technique with the clinically established dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-MRI) for evaluation of brain tumours. A prospective study of 28 patients with contrast-enhancing brain tumours was performed at 3 T using DSC-MRI and PC ASL with whole-brain coverage. The visual qualitative evaluation of signal enhancement in tumour was scored from 0 to 3 (0 = no signal enhancement compared with white matter, 3 = pronounced signal enhancement with equal or higher signal intensity than in grey matter/basal ganglia). The extent of susceptibility artefacts in the tumour was scored from 0 to 2 (0 = no... (More)
The purpose of this study was to compare the non-invasive 3D pseudo-continuous arterial spin labelling (PC ASL) technique with the clinically established dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-MRI) for evaluation of brain tumours. A prospective study of 28 patients with contrast-enhancing brain tumours was performed at 3 T using DSC-MRI and PC ASL with whole-brain coverage. The visual qualitative evaluation of signal enhancement in tumour was scored from 0 to 3 (0 = no signal enhancement compared with white matter, 3 = pronounced signal enhancement with equal or higher signal intensity than in grey matter/basal ganglia). The extent of susceptibility artefacts in the tumour was scored from 0 to 2 (0 = no susceptibility artefacts and 2 = extensive susceptibility artefacts (maximum diameter > 2 cm)). A quantitative analysis was performed with normalised tumour blood flow values (ASL nTBF, DSC nTBF): mean value for region of interest (ROI) in an area with maximum signal enhancement/the mean value for ROIs in cerebellum. There was no difference in total visual score for signal enhancement between PC ASL and DSC relative cerebral blood flow (p = 0.12). ASL had a lower susceptibility-artefact score than DSC-MRI (p = 0.03). There was good correlation between DSC nTBF and ASL nTBF values with a correlation coefficient of 0.82. PC ASL is an alternative to DSC-MRI for the evaluation of perfusion in brain tumours. The method has fewer susceptibility artefacts than DSC-MRI and can be used in patients with renal failure because no contrast injection is needed. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Brain neoplasms, DSC-MRI, ASL, Magnetic resonance imaging, Perfusion
in
Neuroradiology
volume
52
issue
4
pages
307 - 317
publisher
Springer
external identifiers
  • wos:000275422000006
  • scopus:77953049771
  • pmid:19841916
ISSN
1432-1920
DOI
10.1007/s00234-009-0616-6
project
Optimisation and Validation of Dynamic Susceptibility Contrast MRI
MRI brain perfusion quantification at 3 tesla using arterial spin labeling
language
English
LU publication?
yes
id
9a152d45-0b9e-4326-99c4-3b7ff458ba85 (old id 1588235)
date added to LUP
2016-04-01 11:04:34
date last changed
2025-04-04 15:11:20
@article{9a152d45-0b9e-4326-99c4-3b7ff458ba85,
  abstract     = {{The purpose of this study was to compare the non-invasive 3D pseudo-continuous arterial spin labelling (PC ASL) technique with the clinically established dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-MRI) for evaluation of brain tumours. A prospective study of 28 patients with contrast-enhancing brain tumours was performed at 3 T using DSC-MRI and PC ASL with whole-brain coverage. The visual qualitative evaluation of signal enhancement in tumour was scored from 0 to 3 (0 = no signal enhancement compared with white matter, 3 = pronounced signal enhancement with equal or higher signal intensity than in grey matter/basal ganglia). The extent of susceptibility artefacts in the tumour was scored from 0 to 2 (0 = no susceptibility artefacts and 2 = extensive susceptibility artefacts (maximum diameter > 2 cm)). A quantitative analysis was performed with normalised tumour blood flow values (ASL nTBF, DSC nTBF): mean value for region of interest (ROI) in an area with maximum signal enhancement/the mean value for ROIs in cerebellum. There was no difference in total visual score for signal enhancement between PC ASL and DSC relative cerebral blood flow (p = 0.12). ASL had a lower susceptibility-artefact score than DSC-MRI (p = 0.03). There was good correlation between DSC nTBF and ASL nTBF values with a correlation coefficient of 0.82. PC ASL is an alternative to DSC-MRI for the evaluation of perfusion in brain tumours. The method has fewer susceptibility artefacts than DSC-MRI and can be used in patients with renal failure because no contrast injection is needed.}},
  author       = {{Jarnum, Hanna and Steffensen, Elena G. and Knutsson, Linda and Frund, Ernst-Torben and Simonsen, Carsten Wiberg and Lundbye-Christensen, Soren and Shankaranarayanan, Ajit and Alsop, David C. and Jensen, Finn Taagehoj and Larsson, Elna-Marie}},
  issn         = {{1432-1920}},
  keywords     = {{Brain neoplasms; DSC-MRI; ASL; Magnetic resonance imaging; Perfusion}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{307--317}},
  publisher    = {{Springer}},
  series       = {{Neuroradiology}},
  title        = {{Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging}},
  url          = {{http://dx.doi.org/10.1007/s00234-009-0616-6}},
  doi          = {{10.1007/s00234-009-0616-6}},
  volume       = {{52}},
  year         = {{2010}},
}