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Mapping of the bovine blood group systems J, N′, R′, and Z show evidence for oligo-genetic inheritance

Thomsen, H. LU orcid ; Reinsch, N. ; Xu, N. ; Looft, C. ; Grupe, S. ; Kühn, C. ; Brockmann, G. A. ; Schwerin, M. ; Leyhe-Horn, B. and Hiendleder, S. , et al. (2002) In Animal Genetics 33(2). p.107-117
Abstract

Genes determining the bovine erythrocyte antigens were mapped by linkage analysis. In total 9591 genotypes of 20 grandsire families with 1074 sires from a grand-daughter design were elucidated for the genes determining the erythrocyte antigens EAA, EAB, EAC, EAF, EAJ, EAL, EAM, EAN′, EAR′, EAS, EAT′, and EAZ according to standard paternity testing procedures in the blood typing laboratories. Linkage analyses were performed with 248 microsatellite markers, eight SSCP markers and four polymorphic proteins and enzymes covering the 29 autosomes and the pseudoautosomal region of the sex chromosomes. The number of informative meioses for the blood group systems ranged from 76 to 947. Blood group systems EAM and EAT′ were non-informative. Most... (More)

Genes determining the bovine erythrocyte antigens were mapped by linkage analysis. In total 9591 genotypes of 20 grandsire families with 1074 sires from a grand-daughter design were elucidated for the genes determining the erythrocyte antigens EAA, EAB, EAC, EAF, EAJ, EAL, EAM, EAN′, EAR′, EAS, EAT′, and EAZ according to standard paternity testing procedures in the blood typing laboratories. Linkage analyses were performed with 248 microsatellite markers, eight SSCP markers and four polymorphic proteins and enzymes covering the 29 autosomes and the pseudoautosomal region of the sex chromosomes. The number of informative meioses for the blood group systems ranged from 76 to 947. Blood group systems EAM and EAT′ were non-informative. Most of the erythrocyte antigen loci showed significant linkage to a single chromosome and were mapped unequivocally. The genes determining erythrocyte antigen EAA, EAB, EAC, EAL, and EAS were mapped to chromosomes 15, 12, 18, 3, and 21, respectively. Lod-score values ranged from 11.43 to 107.83. Moreover, the EAF system could be mapped to chromosome 17. However, the EAN′ system previously known as part of the EAF system could be mapped to chromosome 5. In addition, the blood group systems EAJ, the new EAN′, EAR′, and EAZ, showed significant linkage to microsatellite markers on various chromosomes and also to other blood groups. The appearance of a single blood group system might be therefore either dependent on the existence of other blood group systems or because of an interaction between different loci on various chromosomes as is known in humans and in pigs.

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publishing date
type
Contribution to journal
publication status
published
keywords
Bovine blood group system, Erythrocyte antigen, Grand-daughter design, Linkage map
in
Animal Genetics
volume
33
issue
2
pages
11 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:0036010112
  • pmid:12047223
ISSN
0268-9146
DOI
10.1046/j.1365-2052.2002.00836.x
language
English
LU publication?
no
id
9a4295c5-fc08-4638-84ef-60b9e5922dd6
date added to LUP
2018-10-10 13:39:58
date last changed
2024-03-16 02:53:19
@article{9a4295c5-fc08-4638-84ef-60b9e5922dd6,
  abstract     = {{<p>Genes determining the bovine erythrocyte antigens were mapped by linkage analysis. In total 9591 genotypes of 20 grandsire families with 1074 sires from a grand-daughter design were elucidated for the genes determining the erythrocyte antigens EAA, EAB, EAC, EAF, EAJ, EAL, EAM, EAN′, EAR′, EAS, EAT′, and EAZ according to standard paternity testing procedures in the blood typing laboratories. Linkage analyses were performed with 248 microsatellite markers, eight SSCP markers and four polymorphic proteins and enzymes covering the 29 autosomes and the pseudoautosomal region of the sex chromosomes. The number of informative meioses for the blood group systems ranged from 76 to 947. Blood group systems EAM and EAT′ were non-informative. Most of the erythrocyte antigen loci showed significant linkage to a single chromosome and were mapped unequivocally. The genes determining erythrocyte antigen EAA, EAB, EAC, EAL, and EAS were mapped to chromosomes 15, 12, 18, 3, and 21, respectively. Lod-score values ranged from 11.43 to 107.83. Moreover, the EAF system could be mapped to chromosome 17. However, the EAN′ system previously known as part of the EAF system could be mapped to chromosome 5. In addition, the blood group systems EAJ, the new EAN′, EAR′, and EAZ, showed significant linkage to microsatellite markers on various chromosomes and also to other blood groups. The appearance of a single blood group system might be therefore either dependent on the existence of other blood group systems or because of an interaction between different loci on various chromosomes as is known in humans and in pigs.</p>}},
  author       = {{Thomsen, H. and Reinsch, N. and Xu, N. and Looft, C. and Grupe, S. and Kühn, C. and Brockmann, G. A. and Schwerin, M. and Leyhe-Horn, B. and Hiendleder, S. and Erhardt, G. and Medjugorac, I. and Russ, I. and Förster, M. and Brenig, B. and Reinhardt, F. and Reents, R. and Blümel, J. and Averdunk, G. and Kalm, E.}},
  issn         = {{0268-9146}},
  keywords     = {{Bovine blood group system; Erythrocyte antigen; Grand-daughter design; Linkage map}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{2}},
  pages        = {{107--117}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Animal Genetics}},
  title        = {{Mapping of the bovine blood group systems J, N′, R′, and Z show evidence for oligo-genetic inheritance}},
  url          = {{http://dx.doi.org/10.1046/j.1365-2052.2002.00836.x}},
  doi          = {{10.1046/j.1365-2052.2002.00836.x}},
  volume       = {{33}},
  year         = {{2002}},
}