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The initial course of il1β, il-6, il-8, il-10, il-12, ifn-γ and tnf-α with regard to severity grade in acute pancreatitis

Sternby, Hanna LU ; Hartman, Hannes LU ; Thorlacius, Henrik LU and Regnér, Sara LU orcid (2021) In Biomolecules 11(4).
Abstract

Clinical reports on early immune dysregulation in acute pancreatitis (AP) are scarce. Herein we investigate the initial temporal development of selected biomarkers. Blood samples were taken at 0–24 and 25–48 h after onsets of AP were acquired. Mean values and temporal intermediate difference (delta-values) of IL-1β, IL-6, IL-8, IL-10, IL-12, IFN-γ and TNF-α were calculated. Differences between severity groups, predictive capacity of the biomarkers and association with severe disease were analyzed. Paired comparison of samples (n = 115) taken at 0–24 and 25–48 h after onsets of AP showed a change over time for IL-1β, IL-6, IL-8 and IL-10 (p < 0.05) and a significant difference between severity groups after 24 h. In ROC-analysis an... (More)

Clinical reports on early immune dysregulation in acute pancreatitis (AP) are scarce. Herein we investigate the initial temporal development of selected biomarkers. Blood samples were taken at 0–24 and 25–48 h after onsets of AP were acquired. Mean values and temporal intermediate difference (delta-values) of IL-1β, IL-6, IL-8, IL-10, IL-12, IFN-γ and TNF-α were calculated. Differences between severity groups, predictive capacity of the biomarkers and association with severe disease were analyzed. Paired comparison of samples (n = 115) taken at 0–24 and 25–48 h after onsets of AP showed a change over time for IL-1β, IL-6, IL-8 and IL-10 (p < 0.05) and a significant difference between severity groups after 24 h. In ROC-analysis an IL-6 cut-off level of 196.6 pg/mL could differentiate severe AP (sensitivity 81.9, specificity 91.3). The delta-values of IL-1β and IL-6 were significantly associated with severe outcomes (odds ratios 1.085 and 1.002, respectively). Data of this work demonstrate a distinct change in IL-1β, IL-8, IL-10 and IL-6 over the first 48 h after onset of AP. The temporal development of biomarkers can assist in the early stratification of the disease. Herein IL-1β and IL-6 were associated with severe disease, however the prognostic capacity of investigated biomarkers is low.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acute pancreatitis, Biomarkers, Chronology, Interleukins, Prognostic markers, Severity
in
Biomolecules
volume
11
issue
4
article number
591
publisher
MDPI AG
external identifiers
  • scopus:85104360246
  • pmid:33920566
ISSN
2218-273X
DOI
10.3390/biom11040591
language
English
LU publication?
yes
id
9a5759f2-144c-4668-96af-b7174dd13bb1
date added to LUP
2021-04-26 10:17:01
date last changed
2024-06-15 10:24:23
@article{9a5759f2-144c-4668-96af-b7174dd13bb1,
  abstract     = {{<p>Clinical reports on early immune dysregulation in acute pancreatitis (AP) are scarce. Herein we investigate the initial temporal development of selected biomarkers. Blood samples were taken at 0–24 and 25–48 h after onsets of AP were acquired. Mean values and temporal intermediate difference (delta-values) of IL-1β, IL-6, IL-8, IL-10, IL-12, IFN-γ and TNF-α were calculated. Differences between severity groups, predictive capacity of the biomarkers and association with severe disease were analyzed. Paired comparison of samples (n = 115) taken at 0–24 and 25–48 h after onsets of AP showed a change over time for IL-1β, IL-6, IL-8 and IL-10 (p &lt; 0.05) and a significant difference between severity groups after 24 h. In ROC-analysis an IL-6 cut-off level of 196.6 pg/mL could differentiate severe AP (sensitivity 81.9, specificity 91.3). The delta-values of IL-1β and IL-6 were significantly associated with severe outcomes (odds ratios 1.085 and 1.002, respectively). Data of this work demonstrate a distinct change in IL-1β, IL-8, IL-10 and IL-6 over the first 48 h after onset of AP. The temporal development of biomarkers can assist in the early stratification of the disease. Herein IL-1β and IL-6 were associated with severe disease, however the prognostic capacity of investigated biomarkers is low.</p>}},
  author       = {{Sternby, Hanna and Hartman, Hannes and Thorlacius, Henrik and Regnér, Sara}},
  issn         = {{2218-273X}},
  keywords     = {{Acute pancreatitis; Biomarkers; Chronology; Interleukins; Prognostic markers; Severity}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{MDPI AG}},
  series       = {{Biomolecules}},
  title        = {{The initial course of il1β, il-6, il-8, il-10, il-12, ifn-γ and tnf-α with regard to severity grade in acute pancreatitis}},
  url          = {{http://dx.doi.org/10.3390/biom11040591}},
  doi          = {{10.3390/biom11040591}},
  volume       = {{11}},
  year         = {{2021}},
}