Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload : Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
(2023) In Diabetes Care 46(5). p.1014-1018- Abstract
OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).
RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.
RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated... (More)
OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).
RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.
RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.
CONCLUSIONS: Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2023-03-03
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Care
- volume
- 46
- issue
- 5
- pages
- 1014 - 1018
- publisher
- American Diabetes Association
- external identifiers
-
- pmid:36867433
- scopus:85159499696
- ISSN
- 1935-5548
- DOI
- 10.2337/dc22-1359
- language
- English
- LU publication?
- yes
- additional info
- © 2023 by the American Diabetes Association.
- id
- 9a78c4f2-aa9c-48d2-b601-ab8b2baf0948
- date added to LUP
- 2023-03-08 18:11:07
- date last changed
- 2024-09-21 10:38:51
@article{9a78c4f2-aa9c-48d2-b601-ab8b2baf0948, abstract = {{<p>OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).</p><p>RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.</p><p>RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.</p><p>CONCLUSIONS: Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.</p>}}, author = {{Thorsen, Steffen U and Liu, Xiang and Kataria, Yachana and Mandrup-Poulsen, Thomas and Kaur, Simranjeet and Uusitalo, Ulla and Virtanen, Suvi M and Norris, Jill M and Rewers, Marian and Hagopian, William and Yang, Jimin and She, Jin-Xiong and Akolkar, Beena and Rich, Stephen and Aronsson, Carin Andrén and Lernmark, Åke and Ziegler, Anette-Gabriele and Toppari, Jorma and Krischer, Jeffrey and Parikh, Hemang M and Ellervik, Christina and Svensson, Jannet}}, issn = {{1935-5548}}, language = {{eng}}, month = {{03}}, number = {{5}}, pages = {{1014--1018}}, publisher = {{American Diabetes Association}}, series = {{Diabetes Care}}, title = {{Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload : Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study}}, url = {{http://dx.doi.org/10.2337/dc22-1359}}, doi = {{10.2337/dc22-1359}}, volume = {{46}}, year = {{2023}}, }