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Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload : Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study

Thorsen, Steffen U ; Liu, Xiang ; Kataria, Yachana ; Mandrup-Poulsen, Thomas ; Kaur, Simranjeet ; Uusitalo, Ulla ; Virtanen, Suvi M ; Norris, Jill M ; Rewers, Marian and Hagopian, William , et al. (2023) In Diabetes Care 46(5). p.1014-1018
Abstract

OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.

RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated... (More)

OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.

RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.

CONCLUSIONS: Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.

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author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
46
issue
5
pages
1014 - 1018
publisher
American Diabetes Association
external identifiers
  • pmid:36867433
  • scopus:85159499696
ISSN
1935-5548
DOI
10.2337/dc22-1359
language
English
LU publication?
yes
additional info
© 2023 by the American Diabetes Association.
id
9a78c4f2-aa9c-48d2-b601-ab8b2baf0948
date added to LUP
2023-03-08 18:11:07
date last changed
2024-06-15 01:32:22
@article{9a78c4f2-aa9c-48d2-b601-ab8b2baf0948,
  abstract     = {{<p>OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).</p><p>RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.</p><p>RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.</p><p>CONCLUSIONS: Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.</p>}},
  author       = {{Thorsen, Steffen U and Liu, Xiang and Kataria, Yachana and Mandrup-Poulsen, Thomas and Kaur, Simranjeet and Uusitalo, Ulla and Virtanen, Suvi M and Norris, Jill M and Rewers, Marian and Hagopian, William and Yang, Jimin and She, Jin-Xiong and Akolkar, Beena and Rich, Stephen and Aronsson, Carin Andrén and Lernmark, Åke and Ziegler, Anette-Gabriele and Toppari, Jorma and Krischer, Jeffrey and Parikh, Hemang M and Ellervik, Christina and Svensson, Jannet}},
  issn         = {{1935-5548}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{5}},
  pages        = {{1014--1018}},
  publisher    = {{American Diabetes Association}},
  series       = {{Diabetes Care}},
  title        = {{Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload : Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study}},
  url          = {{http://dx.doi.org/10.2337/dc22-1359}},
  doi          = {{10.2337/dc22-1359}},
  volume       = {{46}},
  year         = {{2023}},
}