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The Human Diabetes Proteome Project (HDPP) : The 2014 update

Schvartz, D.; Bergsten, Patrik; Baek, K. H.; De La Rosa, A. Barba; Cantley, J.; Dayon, L.; Finamore, F.; Fontana, P.; Gaudet, P. and Goo, Y. A., et al. (2015) In Translational Proteomics 8-9. p.1-7
Abstract

Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with... (More)

Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.

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Contribution to journal
publication status
published
subject
keywords
B/D-HPP, Blood, Diabetes, HDPP, HPP, Human proteome, Islet, Network biology
in
Translational Proteomics
volume
8-9
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:84994462692
ISSN
2212-9626
DOI
10.1016/j.trprot.2015.03.001
language
English
LU publication?
yes
id
9a972185-09d3-4f40-b5e2-f6a13db19065
date added to LUP
2017-02-17 12:02:43
date last changed
2017-09-24 05:07:25
@article{9a972185-09d3-4f40-b5e2-f6a13db19065,
  abstract     = {<p>Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.</p>},
  author       = {Schvartz, D. and Bergsten, Patrik and Baek, K. H. and De La Rosa, A. Barba and Cantley, J. and Dayon, L. and Finamore, F. and Fontana, P. and Gaudet, P. and Goo, Y. A. and Moulder, R. and Goodlett, David R and Johnson, J. D. and Konvalinka, A. and Mulder, Hindrik and Priego-Capote, F. and Sechi, Salvatore and Snyder, Kathleen M. and Tiss, A. and Wiederkehr, A. and Xenarios, I. and Kussmann, Martin and Sanchez, J. C.},
  issn         = {2212-9626},
  keyword      = {B/D-HPP,Blood,Diabetes,HDPP,HPP,Human proteome,Islet,Network biology},
  language     = {eng},
  month        = {12},
  pages        = {1--7},
  publisher    = {Elsevier},
  series       = {Translational Proteomics},
  title        = {The Human Diabetes Proteome Project (HDPP) : The 2014 update},
  url          = {http://dx.doi.org/10.1016/j.trprot.2015.03.001},
  volume       = {8-9},
  year         = {2015},
}