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Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

Foessl, Ines ; Bassett, J. H.Duncan ; Bjørnerem, Åshild ; Busse, Björn ; Calado, Ângelo ; Chavassieux, Pascale ; Christou, Maria ; Douni, Eleni ; Fiedler, Imke A.K. and Fonseca, João Eurico , et al. (2021) In Frontiers in Endocrinology 12.
Abstract

A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are... (More)

A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
animal models, bone and skeletal diseases, COST, GEMSTONE, imaging, phenotyping
in
Frontiers in Endocrinology
volume
12
article number
720728
publisher
Frontiers Media S. A.
external identifiers
  • pmid:34925226
  • scopus:85121349738
ISSN
1664-2392
DOI
10.3389/fendo.2021.720728
language
English
LU publication?
yes
id
9adf4e84-655e-4bc4-870b-7ccca80bd107
date added to LUP
2022-01-26 17:13:02
date last changed
2025-01-26 23:26:06
@article{9adf4e84-655e-4bc4-870b-7ccca80bd107,
  abstract     = {{<p>A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.</p>}},
  author       = {{Foessl, Ines and Bassett, J. H.Duncan and Bjørnerem, Åshild and Busse, Björn and Calado, Ângelo and Chavassieux, Pascale and Christou, Maria and Douni, Eleni and Fiedler, Imke A.K. and Fonseca, João Eurico and Hassler, Eva and Högler, Wolfgang and Kague, Erika and Karasik, David and Khashayar, Patricia and Langdahl, Bente L. and Leitch, Victoria D. and Lopes, Philippe and Markozannes, Georgios and McGuigan, Fiona E.A. and Medina-Gomez, Carolina and Ntzani, Evangelia and Oei, Ling and Ohlsson, Claes and Szulc, Pawel and Tobias, Jonathan H. and Trajanoska, Katerina and Tuzun, Şansın and Valjevac, Amina and van Rietbergen, Bert and Williams, Graham R. and Zekic, Tatjana and Rivadeneira, Fernando and Obermayer-Pietsch, Barbara}},
  issn         = {{1664-2392}},
  keywords     = {{animal models; bone and skeletal diseases; COST; GEMSTONE; imaging; phenotyping}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Endocrinology}},
  title        = {{Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)}},
  url          = {{http://dx.doi.org/10.3389/fendo.2021.720728}},
  doi          = {{10.3389/fendo.2021.720728}},
  volume       = {{12}},
  year         = {{2021}},
}