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Identification of nine new susceptibility loci for endometrial cancer

O’Mara, Tracy A. ; Olsson, Håkan LU ; Thompson, Deborah J. and , (2018) In Nature Communications 9(1).
Abstract
Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of... (More)
Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study. © 2018, The Author(s). (Less)
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organization
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Contribution to journal
publication status
published
subject
in
Nature Communications
volume
9
issue
1
publisher
Nature Publishing Group
external identifiers
  • scopus:85051554034
ISSN
2041-1723
DOI
10.1038/s41467-018-05427-7
language
English
LU publication?
yes
id
9b22f688-0605-4a6c-a1c4-ea27adeb923f
date added to LUP
2018-09-06 10:32:22
date last changed
2019-02-20 11:25:53
@article{9b22f688-0605-4a6c-a1c4-ea27adeb923f,
  abstract     = {Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study. © 2018, The Author(s).},
  articleno    = {3166},
  author       = {O’Mara, Tracy A.  and Olsson, Håkan and Thompson, Deborah J. and , },
  issn         = {2041-1723},
  language     = {eng},
  number       = {1},
  publisher    = {Nature Publishing Group},
  series       = {Nature Communications},
  title        = {Identification of nine new susceptibility loci for endometrial cancer},
  url          = {http://dx.doi.org/10.1038/s41467-018-05427-7},
  volume       = {9},
  year         = {2018},
}