Differences in recruitment and early retention among ethnic minority participants in a large pediatric cohort: The TEDDY Study
(2012) In Contemporary Clinical Trials 33(4). p.633-640- Abstract
- Objective: The TEDDY Study is an international, multi-center prospective study designed to identify the environmental triggers of type 1 diabetes (T1D) in genetically at-risk children. This report investigates ethnic minority (EM) differences in patterns of enrollment and retention in the US centers. Methods: As of June 2009, 267,739 newborns had been screened at birth for high risk T1D genotypes. Data collected at the time of screening, enrollment and at the baseline visit were used. Descriptive and multiple-logistic regression analyses assessed differences between EM groups regarding exclusion, enrollment and early withdrawal. Results: Of the 10,975 eligible subjects, 6,912 (67%) were invited to participate. EM subjects were more likely... (More)
- Objective: The TEDDY Study is an international, multi-center prospective study designed to identify the environmental triggers of type 1 diabetes (T1D) in genetically at-risk children. This report investigates ethnic minority (EM) differences in patterns of enrollment and retention in the US centers. Methods: As of June 2009, 267,739 newborns had been screened at birth for high risk T1D genotypes. Data collected at the time of screening, enrollment and at the baseline visit were used. Descriptive and multiple-logistic regression analyses assessed differences between EM groups regarding exclusion, enrollment and early withdrawal. Results: Of the 10,975 eligible subjects, 6,912 (67%) were invited to participate. EM subjects were more likely to be excluded because of an inability to contact. Of those invited 3,265 (47%) enrolled by the age of 4.5 months. Adjusted analyses showed that except for those classified as other EM, the odds of enrolling were similar across groups. EM subjects had elevated early withdrawal rates. Adjusted models demonstrated that this was significantly more likely among Hispanic subjects. Conclusion: Understanding patterns associated with EM participation in research extends our ability to make more accurate inferences and permits assessment of strategies that promote inclusion of EM to better address health disparities. (C) 2012 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2863715
- author
- Baxter, Judith ; Vehik, Kendra ; Johnson, Suzanne Bennett ; Lernmark, Barbro LU ; Roth, Roswith and Simell, Tuula
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Recruitment, Ethnic-minority, Type 1 diabetes, Retention, Prospective, cohort
- in
- Contemporary Clinical Trials
- volume
- 33
- issue
- 4
- pages
- 633 - 640
- publisher
- Elsevier
- external identifiers
-
- wos:000305711700013
- scopus:84861527847
- pmid:22484339
- ISSN
- 1551-7144
- DOI
- 10.1016/j.cct.2012.03.009
- language
- English
- LU publication?
- yes
- id
- 9b959f9e-ca69-4e61-8ee4-4b1ba83b7888 (old id 2863715)
- date added to LUP
- 2016-04-01 10:54:23
- date last changed
- 2022-01-26 03:34:44
@article{9b959f9e-ca69-4e61-8ee4-4b1ba83b7888,
abstract = {{Objective: The TEDDY Study is an international, multi-center prospective study designed to identify the environmental triggers of type 1 diabetes (T1D) in genetically at-risk children. This report investigates ethnic minority (EM) differences in patterns of enrollment and retention in the US centers. Methods: As of June 2009, 267,739 newborns had been screened at birth for high risk T1D genotypes. Data collected at the time of screening, enrollment and at the baseline visit were used. Descriptive and multiple-logistic regression analyses assessed differences between EM groups regarding exclusion, enrollment and early withdrawal. Results: Of the 10,975 eligible subjects, 6,912 (67%) were invited to participate. EM subjects were more likely to be excluded because of an inability to contact. Of those invited 3,265 (47%) enrolled by the age of 4.5 months. Adjusted analyses showed that except for those classified as other EM, the odds of enrolling were similar across groups. EM subjects had elevated early withdrawal rates. Adjusted models demonstrated that this was significantly more likely among Hispanic subjects. Conclusion: Understanding patterns associated with EM participation in research extends our ability to make more accurate inferences and permits assessment of strategies that promote inclusion of EM to better address health disparities. (C) 2012 Elsevier Inc. All rights reserved.}},
author = {{Baxter, Judith and Vehik, Kendra and Johnson, Suzanne Bennett and Lernmark, Barbro and Roth, Roswith and Simell, Tuula}},
issn = {{1551-7144}},
keywords = {{Recruitment; Ethnic-minority; Type 1 diabetes; Retention; Prospective; cohort}},
language = {{eng}},
number = {{4}},
pages = {{633--640}},
publisher = {{Elsevier}},
series = {{Contemporary Clinical Trials}},
title = {{Differences in recruitment and early retention among ethnic minority participants in a large pediatric cohort: The TEDDY Study}},
url = {{http://dx.doi.org/10.1016/j.cct.2012.03.009}},
doi = {{10.1016/j.cct.2012.03.009}},
volume = {{33}},
year = {{2012}},
}