Cognitive fatigue in relation to depressive symptoms after treatment for childhood cancer
Irestorm, Elin LU
; Tonning Olsson, Ingrid
LU
; Johansson, Birgitta
and Øra, Ingrid
LU
(2020)
In BMC psychology
8.
- Abstract
BACKGROUND: Cognitive fatigue after childhood cancer is frequently overlooked despite guidelines recommending follow-up, and might be mistaken for depression due to overlapping symptoms. Our objectives were: 1) to examine ratings of fatigue in survivors of paediatric brain tumours (BT) and acute lymphoblastic leukaemia (ALL) compared to healthy controls, 2) to examine the relationship between symptoms of depression and cognitive fatigue, and 3) to evaluate parent-child concordance in ratings of cognitive fatigue.
METHODS: Survivors of BT (n = 30), survivors of ALL (n = 30), and healthy controls (n = 60) aged 8-18 years completed the Pediatric Quality of Life Multidimensional Fatigue Scale and the Beck Youth Inventories.... (More)
BACKGROUND: Cognitive fatigue after childhood cancer is frequently overlooked despite guidelines recommending follow-up, and might be mistaken for depression due to overlapping symptoms. Our objectives were: 1) to examine ratings of fatigue in survivors of paediatric brain tumours (BT) and acute lymphoblastic leukaemia (ALL) compared to healthy controls, 2) to examine the relationship between symptoms of depression and cognitive fatigue, and 3) to evaluate parent-child concordance in ratings of cognitive fatigue.
METHODS: Survivors of BT (n = 30), survivors of ALL (n = 30), and healthy controls (n = 60) aged 8-18 years completed the Pediatric Quality of Life Multidimensional Fatigue Scale and the Beck Youth Inventories. Associations between cognitive fatigue, diagnosis and depression were assessed with general linear modelling. Group differences were analysed using the Kruskal-Wallis test. Parent-child concordance was investigated with internal consistency reliability.
RESULTS: Cognitive fatigue was prevalent in 70% of survivors of BT survivors and in 30% of survivors of ALL. Diagnosis was the main predictor of cognitive fatigue (p < .001, ηp2 = 0.178), followed by depression (p = .010, ηp2 = 0.080). Survivors of BT reported significantly more fatigue than healthy controls on all fatigue subscales. While they also expressed more symptoms of depression, we found no evidence for an interaction effect. Parent-child concordance was moderate to good among survivors, but poor for controls.
CONCLUSIONS: Survivors of BT and ALL suffer from cognitive fatigue, with survivors of BT expressing more problems. Cognitive fatigue and depression should be assessed in survivors of childhood cancer using both self-rated and proxy-rated measures, and appropriate interventions offered.
(Less)
- author
- Irestorm, Elin
LU
; Tonning Olsson, Ingrid
LU
; Johansson, Birgitta
and Øra, Ingrid
LU
- organization
- publishing date
- 2020-04-10
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC psychology
- volume
- 8
- article number
- 31
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85083278975
- pmid:32272971
- ISSN
- 2050-7283
- DOI
- 10.1186/s40359-020-00398-1
- project
- Cognitive Fatigue After Cancer Treatment
- language
- English
- LU publication?
- yes
- id
- 9bf9a9c0-4051-4996-800f-18f43f34f892
- date added to LUP
- 2020-04-14 15:34:04
- date last changed
- 2024-05-29 11:19:42
@article{9bf9a9c0-4051-4996-800f-18f43f34f892,
abstract = {{<p>BACKGROUND: Cognitive fatigue after childhood cancer is frequently overlooked despite guidelines recommending follow-up, and might be mistaken for depression due to overlapping symptoms. Our objectives were: 1) to examine ratings of fatigue in survivors of paediatric brain tumours (BT) and acute lymphoblastic leukaemia (ALL) compared to healthy controls, 2) to examine the relationship between symptoms of depression and cognitive fatigue, and 3) to evaluate parent-child concordance in ratings of cognitive fatigue.</p><p>METHODS: Survivors of BT (n = 30), survivors of ALL (n = 30), and healthy controls (n = 60) aged 8-18 years completed the Pediatric Quality of Life Multidimensional Fatigue Scale and the Beck Youth Inventories. Associations between cognitive fatigue, diagnosis and depression were assessed with general linear modelling. Group differences were analysed using the Kruskal-Wallis test. Parent-child concordance was investigated with internal consistency reliability.</p><p>RESULTS: Cognitive fatigue was prevalent in 70% of survivors of BT survivors and in 30% of survivors of ALL. Diagnosis was the main predictor of cognitive fatigue (p < .001, ηp2 = 0.178), followed by depression (p = .010, ηp2 = 0.080). Survivors of BT reported significantly more fatigue than healthy controls on all fatigue subscales. While they also expressed more symptoms of depression, we found no evidence for an interaction effect. Parent-child concordance was moderate to good among survivors, but poor for controls.</p><p>CONCLUSIONS: Survivors of BT and ALL suffer from cognitive fatigue, with survivors of BT expressing more problems. Cognitive fatigue and depression should be assessed in survivors of childhood cancer using both self-rated and proxy-rated measures, and appropriate interventions offered.</p>}},
author = {{Irestorm, Elin and Tonning Olsson, Ingrid and Johansson, Birgitta and Øra, Ingrid}},
issn = {{2050-7283}},
language = {{eng}},
month = {{04}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC psychology}},
title = {{Cognitive fatigue in relation to depressive symptoms after treatment for childhood cancer}},
url = {{http://dx.doi.org/10.1186/s40359-020-00398-1}},
doi = {{10.1186/s40359-020-00398-1}},
volume = {{8}},
year = {{2020}},
}