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Is there evidence for post-translational modification of beta cell autoantigens in the aetiology and pathogenesis of type 1 diabetes?

Lernmark, Åke LU (2013) In Diabetologia 56(11). p.2355-2358
Abstract
Størling and colleagues hypothesise in this issue (Diabetologia DOI: 10.1007/s00125-013-3045-3 ) that post-translational modification (PTM) of autoantigens might create tissue-specific neo-epitopes that could trigger type 1 diabetes. Data on PTM of islet autoantigens are scarce and readers should not believe that the PTM hypothesis is supported by strong experimental evidence. The proposed genetic factors are many but their possible contribution is conjectural. There is a lack of a rational approach to test the PTM hypothesis at the different stages of type 1 diabetes. Research that carefully addresses each stage of the type 1 diabetes disease process is warranted to advance our understanding of autoimmune (type 1) diabetes.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetologia
volume
56
issue
11
pages
2355 - 2358
publisher
Springer
external identifiers
  • wos:000325423600003
  • pmid:24022707
  • scopus:84885857564
ISSN
1432-0428
DOI
10.1007/s00125-013-3041-7
language
English
LU publication?
yes
id
9c71c4bb-964a-4379-9aea-1fd1e581fd28 (old id 4066039)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24022707?dopt=Abstract
date added to LUP
2013-10-01 20:31:45
date last changed
2019-02-20 01:04:49
@article{9c71c4bb-964a-4379-9aea-1fd1e581fd28,
  abstract     = {Størling and colleagues hypothesise in this issue (Diabetologia DOI: 10.1007/s00125-013-3045-3 ) that post-translational modification (PTM) of autoantigens might create tissue-specific neo-epitopes that could trigger type 1 diabetes. Data on PTM of islet autoantigens are scarce and readers should not believe that the PTM hypothesis is supported by strong experimental evidence. The proposed genetic factors are many but their possible contribution is conjectural. There is a lack of a rational approach to test the PTM hypothesis at the different stages of type 1 diabetes. Research that carefully addresses each stage of the type 1 diabetes disease process is warranted to advance our understanding of autoimmune (type 1) diabetes.},
  author       = {Lernmark, Åke},
  issn         = {1432-0428},
  language     = {eng},
  number       = {11},
  pages        = {2355--2358},
  publisher    = {Springer},
  series       = {Diabetologia},
  title        = {Is there evidence for post-translational modification of beta cell autoantigens in the aetiology and pathogenesis of type 1 diabetes?},
  url          = {http://dx.doi.org/10.1007/s00125-013-3041-7},
  volume       = {56},
  year         = {2013},
}