Elevated IL-27 in patients with acute coronary syndrome is associated with adverse ventricular remodeling and increased risk of recurrent myocardial infarction and cardiovascular death
Grufman, Helena ; Yndigegn, Troels LU ; Gonçalves, Isabel LU
; Nilsson, Jan
LU
and Schiopu, Alexandru
LU
(2019)
In Cytokine
122.
- Abstract
Background and aims: IL-27 is an immunoregulatory cytokine belonging to the IL-6/IL-12 family that was found to be elevated in acute coronary syndrome (ACS) patients. We investigated whether IL-27 is related to post-ischemic cardiac remodeling and long-term prognosis in this patient group. Methods: We included 524 ACS patients, defined as acute myocardial infarction (AMI) or unstable angina (UA). A subgroup of 107 patients donated blood samples 6 weeks after the index event, and underwent a follow-up echocardiographical examination at 1 year. We measured plasma levels of IL-27, high sensitivity troponin T (hsTNT), C-reactive protein (hsCRP) and cystatin C at baseline and in the 6-week samples. The median follow-up period of the cohort... (More)
Background and aims: IL-27 is an immunoregulatory cytokine belonging to the IL-6/IL-12 family that was found to be elevated in acute coronary syndrome (ACS) patients. We investigated whether IL-27 is related to post-ischemic cardiac remodeling and long-term prognosis in this patient group. Methods: We included 524 ACS patients, defined as acute myocardial infarction (AMI) or unstable angina (UA). A subgroup of 107 patients donated blood samples 6 weeks after the index event, and underwent a follow-up echocardiographical examination at 1 year. We measured plasma levels of IL-27, high sensitivity troponin T (hsTNT), C-reactive protein (hsCRP) and cystatin C at baseline and in the 6-week samples. The median follow-up period of the cohort was 2.2 years. Results: The incidence of the combined end-point of AMI and cardiovascular death was higher in patients with plasma IL-27 within the top two tertiles both at baseline and after 6 weeks. After correction for cardiovascular risk factors, medication, hsTNT, hsCRP, and eGFR, patients with baseline IL-27 levels within the highest tertile had a significantly elevated risk for the combined end-point compared with the lowest tertile (hazard ratio 2.70, 95% CI 1.06–6.90, p =.038). Additionally, higher baseline IL-27 levels were associated with deleterious left ventricular remodeling and deterioration of systolic and diastolic function during the first year of follow-up. Conclusions: Elevated IL-27 at the time of an ACS is independently related to impaired cardiac function and worse long-term prognosis. Our data warrants further mechanistic studies to elucidate the involvement of IL-27 in cardiac repair and remodeling after ACS.
(Less)
- author
- Grufman, Helena
; Yndigegn, Troels
LU
; Gonçalves, Isabel
LU
; Nilsson, Jan
LU
and Schiopu, Alexandru
LU
- organization
- publishing date
- 2019-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cardiovascular death, IL-27, Inflammation, Myocardial infarction, Ventricular remodeling
- in
- Cytokine
- volume
- 122
- article number
- 154208
- publisher
- Academic Press
- external identifiers
-
- scopus:85044657044
- pmid:29428559
- ISSN
- 1043-4666
- DOI
- 10.1016/j.cyto.2017.11.002
- language
- English
- LU publication?
- yes
- id
- 9ca8ef97-1361-4393-8e5b-6082ccc04e8f
- date added to LUP
- 2018-04-11 15:03:22
- date last changed
- 2024-06-24 12:57:06
@article{9ca8ef97-1361-4393-8e5b-6082ccc04e8f,
abstract = {{<p>Background and aims: IL-27 is an immunoregulatory cytokine belonging to the IL-6/IL-12 family that was found to be elevated in acute coronary syndrome (ACS) patients. We investigated whether IL-27 is related to post-ischemic cardiac remodeling and long-term prognosis in this patient group. Methods: We included 524 ACS patients, defined as acute myocardial infarction (AMI) or unstable angina (UA). A subgroup of 107 patients donated blood samples 6 weeks after the index event, and underwent a follow-up echocardiographical examination at 1 year. We measured plasma levels of IL-27, high sensitivity troponin T (hsTNT), C-reactive protein (hsCRP) and cystatin C at baseline and in the 6-week samples. The median follow-up period of the cohort was 2.2 years. Results: The incidence of the combined end-point of AMI and cardiovascular death was higher in patients with plasma IL-27 within the top two tertiles both at baseline and after 6 weeks. After correction for cardiovascular risk factors, medication, hsTNT, hsCRP, and eGFR, patients with baseline IL-27 levels within the highest tertile had a significantly elevated risk for the combined end-point compared with the lowest tertile (hazard ratio 2.70, 95% CI 1.06–6.90, p =.038). Additionally, higher baseline IL-27 levels were associated with deleterious left ventricular remodeling and deterioration of systolic and diastolic function during the first year of follow-up. Conclusions: Elevated IL-27 at the time of an ACS is independently related to impaired cardiac function and worse long-term prognosis. Our data warrants further mechanistic studies to elucidate the involvement of IL-27 in cardiac repair and remodeling after ACS.</p>}},
author = {{Grufman, Helena and Yndigegn, Troels and Gonçalves, Isabel and Nilsson, Jan and Schiopu, Alexandru}},
issn = {{1043-4666}},
keywords = {{Cardiovascular death; IL-27; Inflammation; Myocardial infarction; Ventricular remodeling}},
language = {{eng}},
publisher = {{Academic Press}},
series = {{Cytokine}},
title = {{Elevated IL-27 in patients with acute coronary syndrome is associated with adverse ventricular remodeling and increased risk of recurrent myocardial infarction and cardiovascular death}},
url = {{http://dx.doi.org/10.1016/j.cyto.2017.11.002}},
doi = {{10.1016/j.cyto.2017.11.002}},
volume = {{122}},
year = {{2019}},
}