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Contact allergy to oxidized geraniol among Swedish dermatitis patients—A multicentre study by the Swedish Contact Dermatitis Research Group

Hagvall, Lina; Bruze, Magnus LU ; Engfeldt, Malin LU ; Isaksson, Marléne LU ; Lindberg, Magnus; Ryberg, Kristina LU ; Stenberg, Berndt; Svedman, Cecilia LU ; Karlberg, Ann Therese and Bråred Christensson, Johanna (2018) In Contact Dermatitis 79(4). p.232-238
Abstract

Background: Geraniol is a widely used fragrance terpene, and is included in fragrance mix I. Geraniol is prone to autoxidation, forming the skin sensitizers geranial, neral, and geraniol-7-hydroperoxide. Oxidized geraniol has previously been patch tested in 1 clinic, giving 1% to 4.6% positive reactions in consecutive patients when tested at 2% to 11%. Aim: To compare test reactions to pure and oxidized geraniol, to compare 2 different test concentrations of oxidized geraniol and to investigate the pattern of concomitant reactions to fragrance markers of the baseline series in a multicentre setting. Methods: One thousand four hundred and seventy-six consecutive patients referred for patch testing were patch tested with geraniol 6% pet.... (More)

Background: Geraniol is a widely used fragrance terpene, and is included in fragrance mix I. Geraniol is prone to autoxidation, forming the skin sensitizers geranial, neral, and geraniol-7-hydroperoxide. Oxidized geraniol has previously been patch tested in 1 clinic, giving 1% to 4.6% positive reactions in consecutive patients when tested at 2% to 11%. Aim: To compare test reactions to pure and oxidized geraniol, to compare 2 different test concentrations of oxidized geraniol and to investigate the pattern of concomitant reactions to fragrance markers of the baseline series in a multicentre setting. Methods: One thousand four hundred and seventy-six consecutive patients referred for patch testing were patch tested with geraniol 6% pet. and oxidized geraniol 6% and 11% pet. Results: Pure geraniol 6% pet., oxidized geraniol 6% pet. and oxidized geraniol 11% pet. gave 1%, 3% and 8% positive patch test reactions and 0.7%, 3% and 5% doubtful reactions, respectively. Approximately 50% of the patients with doubtful reactions to oxidized geraniol 6% pet. had positive reactions to oxidized geraniol 11% pet. Conclusions: Oxidized geraniol 11% pet. provides better detection than oxidized geraniol 6% pet. As most patients reacted only to oxidized geraniol, it is important to explore further whether oxidized geraniol should be included in a baseline patch test series.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
allergic contact dermatitis, autoxidation, fragrance contact allergy, fragrance mix I, geraniol, patch testing, terpenes
in
Contact Dermatitis
volume
79
issue
4
pages
7 pages
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:85052815523
ISSN
0105-1873
DOI
10.1111/cod.13047
language
English
LU publication?
yes
id
9cddf06c-db4f-499f-9d54-74d36e5c4364
date added to LUP
2018-09-25 10:52:54
date last changed
2019-01-06 14:05:35
@article{9cddf06c-db4f-499f-9d54-74d36e5c4364,
  abstract     = {<p>Background: Geraniol is a widely used fragrance terpene, and is included in fragrance mix I. Geraniol is prone to autoxidation, forming the skin sensitizers geranial, neral, and geraniol-7-hydroperoxide. Oxidized geraniol has previously been patch tested in 1 clinic, giving 1% to 4.6% positive reactions in consecutive patients when tested at 2% to 11%. Aim: To compare test reactions to pure and oxidized geraniol, to compare 2 different test concentrations of oxidized geraniol and to investigate the pattern of concomitant reactions to fragrance markers of the baseline series in a multicentre setting. Methods: One thousand four hundred and seventy-six consecutive patients referred for patch testing were patch tested with geraniol 6% pet. and oxidized geraniol 6% and 11% pet. Results: Pure geraniol 6% pet., oxidized geraniol 6% pet. and oxidized geraniol 11% pet. gave 1%, 3% and 8% positive patch test reactions and 0.7%, 3% and 5% doubtful reactions, respectively. Approximately 50% of the patients with doubtful reactions to oxidized geraniol 6% pet. had positive reactions to oxidized geraniol 11% pet. Conclusions: Oxidized geraniol 11% pet. provides better detection than oxidized geraniol 6% pet. As most patients reacted only to oxidized geraniol, it is important to explore further whether oxidized geraniol should be included in a baseline patch test series.</p>},
  author       = {Hagvall, Lina and Bruze, Magnus and Engfeldt, Malin and Isaksson, Marléne and Lindberg, Magnus and Ryberg, Kristina and Stenberg, Berndt and Svedman, Cecilia and Karlberg, Ann Therese and Bråred Christensson, Johanna},
  issn         = {0105-1873},
  keyword      = {allergic contact dermatitis,autoxidation,fragrance contact allergy,fragrance mix I,geraniol,patch testing,terpenes},
  language     = {eng},
  month        = {06},
  number       = {4},
  pages        = {232--238},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Contact allergy to oxidized geraniol among Swedish dermatitis patients—A multicentre study by the Swedish Contact Dermatitis Research Group},
  url          = {http://dx.doi.org/10.1111/cod.13047},
  volume       = {79},
  year         = {2018},
}