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Complementary pre-screening strategies to uncover hidden prodromal and mild Alzheimer's disease : Results from the MOPEAD project

Boada, Mercè ; Rodrigo, Adrián ; Jessen, Frank ; Wimblad, Bengt ; Kramberger, Milika ; Visser, Pieter Jelle ; Simó, Rafael ; Rodríguez-Gomez, Octavio ; Ciudin, Andreea and Georges, Jean , et al. (2022) In Alzheimer's and Dementia 18(6). p.1119-1127
Abstract

Introduction: The Models of Patient Engagement for Alzheimer's Disease (MOPEAD) project was conceived to explore innovative complementary strategies to uncover hidden prodromal and mild Alzheimer's disease (AD) dementia cases and to raise awareness both in the general public and among health professionals about the importance of early diagnosis. Methods: Four different strategies or RUNs were used: (a) a web-based (WB) prescreening tool, (2) an open house initiative (OHI), (3) a primary care–based protocol for early detection of cognitive decline (PC), and (4) a tertiary care–based pre-screening at diabetologist clinics (DC). Results: A total of 1129 patients at high risk of having prodromal AD or dementia were identified of 2847... (More)

Introduction: The Models of Patient Engagement for Alzheimer's Disease (MOPEAD) project was conceived to explore innovative complementary strategies to uncover hidden prodromal and mild Alzheimer's disease (AD) dementia cases and to raise awareness both in the general public and among health professionals about the importance of early diagnosis. Methods: Four different strategies or RUNs were used: (a) a web-based (WB) prescreening tool, (2) an open house initiative (OHI), (3) a primary care–based protocol for early detection of cognitive decline (PC), and (4) a tertiary care–based pre-screening at diabetologist clinics (DC). Results: A total of 1129 patients at high risk of having prodromal AD or dementia were identified of 2847 pre-screened individuals (39.7%). The corresponding proportion for the different initiatives were 36.8% (WB), 35.6% (OHI), 44.4% (PC), and 58.3% (DC). Conclusion: These four complementary pre-screening strategies were useful for identifying individuals at high risk of having prodromal or mild AD.

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@article{9d423917-c3cd-42eb-9855-e06e0194c5ba,
  abstract     = {{<p>Introduction: The Models of Patient Engagement for Alzheimer's Disease (MOPEAD) project was conceived to explore innovative complementary strategies to uncover hidden prodromal and mild Alzheimer's disease (AD) dementia cases and to raise awareness both in the general public and among health professionals about the importance of early diagnosis. Methods: Four different strategies or RUNs were used: (a) a web-based (WB) prescreening tool, (2) an open house initiative (OHI), (3) a primary care–based protocol for early detection of cognitive decline (PC), and (4) a tertiary care–based pre-screening at diabetologist clinics (DC). Results: A total of 1129 patients at high risk of having prodromal AD or dementia were identified of 2847 pre-screened individuals (39.7%). The corresponding proportion for the different initiatives were 36.8% (WB), 35.6% (OHI), 44.4% (PC), and 58.3% (DC). Conclusion: These four complementary pre-screening strategies were useful for identifying individuals at high risk of having prodromal or mild AD.</p>}},
  author       = {{Boada, Mercè and Rodrigo, Adrián and Jessen, Frank and Wimblad, Bengt and Kramberger, Milika and Visser, Pieter Jelle and Simó, Rafael and Rodríguez-Gomez, Octavio and Ciudin, Andreea and Georges, Jean and Dumas, Annete and Maguire, Peggy and Krivec, David and Wimo, Anders and Valero, Sergi and Alegret, Montserrat and Jamilis, Laura and Zwan, Marissa and Sannemann, Lena and Arrufat, Jordi and Stomrud, Erik and Johansson, Gunilla and Shering, Craig and Glaysher, Bridget and Stewart, Neil and Belger, Mark and Iradier, Fatima and Campo, Laura}},
  issn         = {{1552-5260}},
  keywords     = {{Alzheimer's disease; diagnostic gap; early diagnosis; patient engagement; population-based screening}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1119--1127}},
  publisher    = {{Wiley}},
  series       = {{Alzheimer's and Dementia}},
  title        = {{Complementary pre-screening strategies to uncover hidden prodromal and mild Alzheimer's disease : Results from the MOPEAD project}},
  url          = {{http://dx.doi.org/10.1002/alz.12441}},
  doi          = {{10.1002/alz.12441}},
  volume       = {{18}},
  year         = {{2022}},
}