Convergence of Synapses, Endosomes, and Prions in the Biology of Neurodegenerative Diseases.
Gouras, Gunnar LU
(2013)
In International Journal of Cell Biology
2013.
- Abstract
- Age-related misfolding and aggregation of disease-linked proteins in selective brain regions is a characteristic of neurodegenerative diseases. Although neuropathological aggregates that characterize these various diseases are found at sites other than synapses, increasing evidence supports the idea that synapses are where the pathogenesis begins. Understanding these diseases is hampered by our lack of knowledge of what the normal functions of these proteins are and how they are affected by aging. Evidence has supported the idea that neurodegenerative disease-linked proteins have a common propensity for prion protein-like cell-to-cell propagation. However, it is not thought that the prion-like quality of these proteins/peptides that allows... (More)
- Age-related misfolding and aggregation of disease-linked proteins in selective brain regions is a characteristic of neurodegenerative diseases. Although neuropathological aggregates that characterize these various diseases are found at sites other than synapses, increasing evidence supports the idea that synapses are where the pathogenesis begins. Understanding these diseases is hampered by our lack of knowledge of what the normal functions of these proteins are and how they are affected by aging. Evidence has supported the idea that neurodegenerative disease-linked proteins have a common propensity for prion protein-like cell-to-cell propagation. However, it is not thought that the prion-like quality of these proteins/peptides that allows their cell-to-cell transmission implies a role for human-to-human spread in common age-related neurodegenerative diseases. It will be important to better understand the molecular and cellular mechanisms governing the role of these aggregating proteins in neural function, especially at synapses, how their propagation occurs and how pathogenesis is promoted by aging. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4225194
- author
- Gouras, Gunnar
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Cell Biology
- volume
- 2013
- article number
- 141083
- publisher
- Hindawi Limited
- external identifiers
-
- pmid:24307901
- scopus:84888863049
- pmid:24307901
- ISSN
- 1687-8876
- DOI
- 10.1155/2013/141083
- language
- English
- LU publication?
- yes
- id
- 9d760420-daaf-44fe-95fa-39d127a4ba48 (old id 4225194)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24307901?dopt=Abstract
- date added to LUP
- 2016-04-01 10:09:59
- date last changed
- 2022-01-25 20:25:34
@article{9d760420-daaf-44fe-95fa-39d127a4ba48,
abstract = {{Age-related misfolding and aggregation of disease-linked proteins in selective brain regions is a characteristic of neurodegenerative diseases. Although neuropathological aggregates that characterize these various diseases are found at sites other than synapses, increasing evidence supports the idea that synapses are where the pathogenesis begins. Understanding these diseases is hampered by our lack of knowledge of what the normal functions of these proteins are and how they are affected by aging. Evidence has supported the idea that neurodegenerative disease-linked proteins have a common propensity for prion protein-like cell-to-cell propagation. However, it is not thought that the prion-like quality of these proteins/peptides that allows their cell-to-cell transmission implies a role for human-to-human spread in common age-related neurodegenerative diseases. It will be important to better understand the molecular and cellular mechanisms governing the role of these aggregating proteins in neural function, especially at synapses, how their propagation occurs and how pathogenesis is promoted by aging.}},
author = {{Gouras, Gunnar}},
issn = {{1687-8876}},
language = {{eng}},
publisher = {{Hindawi Limited}},
series = {{International Journal of Cell Biology}},
title = {{Convergence of Synapses, Endosomes, and Prions in the Biology of Neurodegenerative Diseases.}},
url = {{https://lup.lub.lu.se/search/files/1618344/4438264}},
doi = {{10.1155/2013/141083}},
volume = {{2013}},
year = {{2013}},
}